본문 바로가기
KERD
논문KCI 등재

Voriconazole-refractory invasive aspergillosis

1

조회

0

다운로드

1

인용

0

참고문헌

키워드

주제분류내과학

초록

Invasive aspergillosis (IA) is one of the most common life-threatening complications in immunocompromised patients. Voriconazole is currently the drug of choice for IA treatment. However, some patients with IA suffer clinical deterioration despite voriconazole therapy. Management of voriconazole-refractory IA remains challenging; no useful recommendations have yet been made. Voriconazole-refractory IA can be further categorized as disease attributable to misdiagnosis or co-infection with another mold; inadequate blood voriconazole blood; inadequate tissue drug concentrations attributable to angioinvasion; immune reconstitution inflammatory syndrome; or infection with voriconazole-resistant Aspergillus. Hence, when encountering a case of voriconazole-refractory IA, it is necessary to schedule sequential tests to decide whether medical treatment or surgical intervention is appropriate; to adjust the voriconazole dose via drug monitoring; to seek CYP2C19 polymorphisms; to monitor serum galactomannan levels; and to examine the drug susceptibility of the causative Aspergillus species.

Abstract

Invasive aspergillosis (IA) is one of the most common life-threatening complications in immunocompromised patients. Voriconazole is currently the drug of choice for IA treatment. However, some patients with IA suffer clinical deterioration despite voriconazole therapy. Management of voriconazole-refractory IA remains challenging; no useful recommendations have yet been made. Voriconazole-refractory IA can be further categorized as disease attributable to misdiagnosis or co-infection with another mold; inadequate blood voriconazole blood; inadequate tissue drug concentrations attributable to angioinvasion; immune reconstitution inflammatory syndrome; or infection with voriconazole-resistant Aspergillus. Hence, when encountering a case of voriconazole-refractory IA, it is necessary to schedule sequential tests to decide whether medical treatment or surgical intervention is appropriate; to adjust the voriconazole dose via drug monitoring; to seek CYP2C19 polymorphisms; to monitor serum galactomannan levels; and to examine the drug susceptibility of the causative Aspergillus species.

참고문헌 (37)

  1. 김성한, "침습성 폐 아스페르길루스증의 역학과 임상상: 전국 다기관 연구", Infection and Chemotherapy, 44(4), pp.282~288 (2012), 대한감염학회
  2. 윤지현, "Infections after lung transplantation: time of occurrence, sites, and microbiologic etiologies", The Korean Journal of Internal Medicine, 30(4), pp.506~514 (2015), 대한내과학회[DOI]
  3. Herbrecht R, "Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis", N Engl J Med, 347, pp.408~415 (2002)
  4. Walsh TJ, "Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of America", Clin Infect Dis, 46, pp.327~360 (2008)
  5. Hope WW, "Laboratory diagnosis of invasive aspergillosis", Lancet Infect Dis, 5, pp.609~622 (2005)
  6. Jung J, "Using immunohistochemistry to assess the accuracy of histomorphologic diagnosis of aspergillosis and mucormycosis", Clin Infect Dis, 61, pp.1664~1670 (2015)
  7. De Pauw B, "Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer", Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC, Clin Infect Dis, pp.2008, 46[DOI]
  8. Kedzierska A, "Current status of fungal cell wall components in the immunodiagnostics of invasive fungal infections in humans: galactomannan, mannan and (1→3)-beta-D-glucan antigens", Eur J Clin Microbiol Infect Dis, 26, pp.755~766 (2007)
  9. Park SY, "Aspergillus galactomannan antigen assay in bronchoalveolar lavage fluid for diagnosis of invasive pulmonary aspergillosis", J Infect, 61, pp.492~498 (2010)
  10. Yildiz Okuturlar, "Serum galactomannan levels in the diagnosis of invasive aspergillosis", The Korean Journal of Internal Medicine, 30(6), pp.899~905 (2015), 대한내과학회[DOI]
  11. Kim SH, "Invasive pulmonary aspergillosis-mimicking tuberculosis", Clin Infect Dis, 61, pp.9~17 (2015)
  12. Kontoyiannis DP, "Zygomycosis in the 1990s in a tertiary-care cancer center", Clin Infect Dis, 30, pp.851~856 (2000)
  13. Marr KA, "Combination antifungal therapy for invasive aspergillosis: a randomized trial", Ann Intern Med, 162, pp.81~89 (2015)
  14. Reed C, "Combination polyene-caspofungin treatment of rhino-orbital-cerebral mucormycosis", Clin Infect Dis, 47, pp.364~371 (2008)
  15. Caillot D, "Liposomal amphotericin B in combination with caspofungin for invasive aspergillosis in patients with hematologic malignancies:a randomized pilot study (Combistrat trial)", Cancer, 110, pp.2740~2746 (2007)
  16. Cornely OA, "Treatment outcome of invasive mould disease after sequential exposure to azoles and liposomal amphotericin B", J Antimicrob Chemother, 65, pp.114~117 (2010)
  17. Maertens JA, "Isavuconazole versus voriconazole for primary treatment of invasive mould disease caused by Aspergillus and other filamentous fungi (SECURE): a phase 3, randomised-controlled, non-inferiority trial", Lancet, 387, pp.760~769 (2016)
  18. Walsh TJ, "Treatment of invasive aspergillosis with posaconazole in patients who are refractory to or intolerant of conventional therapy: an externally controlled trial", Clin Infect Dis, 44, pp.2~12 (2007)
  19. Pascual A, "Voriconazole therapeutic drug monitoring in patients with invasive mycoses improves efficacy and safety outcomes", Clin Infect Dis, 46, pp.201~211 (2008)
  20. Miyakis S, "Voriconazole concentrations and outcome of invasive fungal infections", Clin Microbiol Infect, 16, pp.927~933 (2010)
  21. Lee YJ, "Initial voriconazole trough blood levels and clinical outcomes of invasive aspergillosis in patients with hematologic malignancies", Med Mycol, 51, pp.324~330 (2013)
  22. Park WB, "The effect of therapeutic drug monitoring on safety and efficacy of voriconazole in invasive fungal infections: a randomized controlled trial", Clin Infect Dis, 55, pp.1080~1087 (2012)
  23. Abidi MZ, "CYP2C19*17 genetic polymorphism: an uncommon cause of voriconazole treatment failure", Diagn Microbiol Infect Dis, 83, pp.46~48 (2015)
  24. Jung J, "Comparison of computed tomographic findings in pulmonary mucormycosis and invasive pulmonary aspergillosis", Clin Microbiol Infect, 21, pp.684~ (2015)
  25. Caillot D, "Computer tomography in pulmonary invasive aspergillosis in hematological patients with neutropenia: an useful tool for diagnosis and assessment of outcome in clinical trials", Eur J Radiol, 74, pp.e172~e175 (2010)
  26. Miceli MH, "Immune reconstitution inflammatory syndrome in cancer patients with pulmonary aspergillosis recovering from neutropenia:proof of principle, description, and clinical and research implications", Cance, 110, pp.112~120 (2007)
  27. Jung J, "Immune reconstitution inflammatory syndrome in neutropenic patients with invasive pulmonary aspergillosis", J Infect, 70, pp.659~667 (2015)
  28. Simitsopoulou M, "Immunomodulatory effects of voriconazole on monocytes challenged with Aspergillus fumigatus: differential role of Toll-like receptors", Antimicrob Agents Chemother, 52, pp.3301~3306 (2008)
  29. Arendrup MC., "Update on antifungal resistance in Aspergillus and Candida", Clin Microbiol Infect, 20(Suppl 6), pp.42~48 (2014)
  30. Verweij PE, "Azole resistance in Aspergillus fumigatus: can we retain the clinical use of mold-active antifungal azoles?", Clin Infect Dis, 62, pp.362~368 (2016)
  31. Howard SJ, "Frequency and evolution of azole resistance in Aspergillus fumigatus associated with treatment failure", Emerg Infect Dis, 15, pp.1068~1076 (2009)
  32. van der Linden JW, "Clinical implications of azole resistance in Aspergillus fumigatus, The Netherlands, 2007-2009", Emerg Infect Dis, 17, pp.1846~1854 (2011)
  33. Escribano P, "Is azole resistance in Aspergillus fumigatus a problem in Spain?", Antimicrob Agents Chemother, 57, pp.2815~2820 (2013)
  34. Toyotome T, "Azole susceptibility in clinical and environmental isolates of Aspergillus fumigatus from eastern Hokkaido, Japan", J Infect Chemother, 22, pp.648~650 (2016)
  35. Lepak AJ, "Impact of in vivo triazole and echinocandin combination therapy for invasive pulmonary aspergillosis: enhanced efficacy against Cyp51 mutant isolates", Antimicrob Agents Chemother, 57, pp.5438~5447 (2013)
  36. van der Linden JW, "Aspergillosis due to voriconazole highly resistant Aspergillus fumigatus and recovery of genetically related resistant isolates from domiciles", Clin Infect Dis, 57, pp.513~520 (2013)
  37. Caillot D, "Role of early diagnosis and aggressive surgery in the management of invasive pulmonary aspergillosis in neutropenic patients", Clin Microbiol Infect, 7(Suppl 2), pp.54~61 (2001)

관련 논문AI추천

이 간행물의 다른 논문 (27건)