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Relationship Between Acanthosis Nigricans and Fungal Infection: Clinical and Histopathological findings

박은주|김광호|홍은혜|김광중|정준우
대한의진균학회 (The Korean Society for Medical Mycology)|2021.03|대한의진균학회지 (Journal of Mycology and Infection)|제26권 제1호|pp. 1-7

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참고문헌

키워드

Acanthosis nigricansFungal infectionPapillomatosis
주제분류미생물학

초록

Background: Acanthosis nigricans (AN) is a skin condition that presents clinically with hyperpigmented, hyperkeratotic, and velvety skin changes, especially in the intertriginous areas. The intertriginous areas are also susceptible to superficial cutaneous fungal infections. The potential relationship between AN and cutaneous fungal infection has not been investigated. Objective: The aim of this study was to determine the relationship, if any, between AN and fungal infection, both clinically and pathologically. Methods: A retrospective review was performed using electronic medical records and histology of biopsy slides obtained from 29 patients who were diagnosed with AN by two dermatopathologists. Comparison was made between the clinical and pathological findings of AN with fungal infection (ANFI+) and AN without fungal infection (ANFI-). Results: Among the 29 patients with AN, fungal spores were detected on the biopsy slides of 18 patients (62.1%) and appeared in the epidermal furrow more often than in the epidermal ridge. No significant clinical difference was found between the ANFI+ and ANFI- groups; however, in the ANFI+ group, lesions were more prevalent in the neck area (p = 0.048). In addition, the ANFI+ biopsy slides revealed more papillomatosis than ANFI- biopsy slides (p = 0.006). Conclusion: Fungal infection tends to appear in combination with AN when more severe papillomatosis is also present.

Abstract

Background: Acanthosis nigricans (AN) is a skin condition that presents clinically with hyperpigmented, hyperkeratotic, and velvety skin changes, especially in the intertriginous areas. The intertriginous areas are also susceptible to superficial cutaneous fungal infections. The potential relationship between AN and cutaneous fungal infection has not been investigated. Objective: The aim of this study was to determine the relationship, if any, between AN and fungal infection, both clinically and pathologically. Methods: A retrospective review was performed using electronic medical records and histology of biopsy slides obtained from 29 patients who were diagnosed with AN by two dermatopathologists. Comparison was made between the clinical and pathological findings of AN with fungal infection (ANFI+) and AN without fungal infection (ANFI-). Results: Among the 29 patients with AN, fungal spores were detected on the biopsy slides of 18 patients (62.1%) and appeared in the epidermal furrow more often than in the epidermal ridge. No significant clinical difference was found between the ANFI+ and ANFI- groups; however, in the ANFI+ group, lesions were more prevalent in the neck area (p = 0.048). In addition, the ANFI+ biopsy slides revealed more papillomatosis than ANFI- biopsy slides (p = 0.006). Conclusion: Fungal infection tends to appear in combination with AN when more severe papillomatosis is also present.

참고문헌 (26)

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관련 논문AI추천

A Suspected Case of Hyperkeratotic Head and Neck Malassezia Dermatosis Presenting with Acanthosis Nigricans김광호, 박은주, 안민균, 윤지하, 조은별대한의진균학회 · 대한의진균학회지2018 · 제23권 제4호Three cases of concomitant acanthosis nigricans with confluent and reticulated papillomatosis in obese patients이은, 강봉선, 이정덕, 조상현대한피부과학회 · Annals of Dermatology2008 · 제20권 제2호Unusual Presentation of Obesity-associated Dermatoses: Acanthosis Nigricans Involving Both Auricles이영복, 이정덕, 조상현대한피부과학회 · Annals of Dermatology2010 · 제22권 제4호Clinical and Histopathologic Study of Confluent and Reticulated Papillomatosis by Anatomic Site and Age구대원, 이중선, 정경은, 조영민대한피부과학회 · Annals of Dermatology2018 · 제30권 제5호Dermatomycosis from the Perspective of Dermatopathology (Version 1.1)김택운, 박준수, 이정수대한의진균학회 · 대한의진균학회지2021 · 제26권 제3호Skin Characteristics in Patients with Pityriasis Versicolor Using Non-Invasive Method, MPA5안규중, 이양원, 최용범, Hyun Jung Park대한피부과학회 · Annals of Dermatology2012 · 제24권 제4호

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