Levels of adherence and factors associated with adherence to option B+ prevention of mother-to-child transmission among pregnant and lactating mothers in selected government health facilities of South Wollo Zone, Amhara Region, northeast Ethiopia, 2016
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OBJECTIVES: The aim of this study was to measure the levels of adherence and to identify factors associated with adherence to option B+ prevention of mother-to-child transmission (PMTCT) among pregnant and lactating mothers in selected government health facilities of South Wollo Zone, Amhara Region, northeast Ethiopia. METHODS: An institution-based cross-sectional quantitative study design was employed from March 1, 2016 to April 14, 2016, using a standard structured data collection instrument. A sample of 191 human immunodeficiency virus (HIV)-positive pregnant and lactating mothers who were receiving PMTCT follow-up in the selected health facilities participated in the study. The data were entered using EpiData 3.1 and analyzed using SPSS version 21. Bivariate and multivariate logistic regression analyses were employed to identify factors associated with adherence. The p-values <0.05 and 95% confidence intervals (CIs) were used to identify associations between independent predictors and the outcome variable. RESULTS: The level of adherence to option B+ PMTCT drugs was 87.9%. Women who received in-hospital treatment, who lived in rural areas, and faced challenges in initiating lifelong option B+ treatment on the same-day that they were diagnosed with HIV were less likely to adhere to the treatment (adjusted odds ratios [95% CI] of 0.3 [0.11 to 0.82], 0.26 [0.1 to 0.73], and 0.08 [0.02 to 0.37], respectively). CONCLUSIONS: Collaborative efforts of zonal health departments with health facility administrators and counselors are recommended for effective and efficient interventions focusing on hospitals, rural areas, and patients who face challenges on the day of their diagnosis.
Abstract
OBJECTIVES: The aim of this study was to measure the levels of adherence and to identify factors associated with adherence to option B+ prevention of mother-to-child transmission (PMTCT) among pregnant and lactating mothers in selected government health facilities of South Wollo Zone, Amhara Region, northeast Ethiopia. METHODS: An institution-based cross-sectional quantitative study design was employed from March 1, 2016 to April 14, 2016, using a standard structured data collection instrument. A sample of 191 human immunodeficiency virus (HIV)-positive pregnant and lactating mothers who were receiving PMTCT follow-up in the selected health facilities participated in the study. The data were entered using EpiData 3.1 and analyzed using SPSS version 21. Bivariate and multivariate logistic regression analyses were employed to identify factors associated with adherence. The p-values <0.05 and 95% confidence intervals (CIs) were used to identify associations between independent predictors and the outcome variable. RESULTS: The level of adherence to option B+ PMTCT drugs was 87.9%. Women who received in-hospital treatment, who lived in rural areas, and faced challenges in initiating lifelong option B+ treatment on the same-day that they were diagnosed with HIV were less likely to adhere to the treatment (adjusted odds ratios [95% CI] of 0.3 [0.11 to 0.82], 0.26 [0.1 to 0.73], and 0.08 [0.02 to 0.37], respectively). CONCLUSIONS: Collaborative efforts of zonal health departments with health facility administrators and counselors are recommended for effective and efficient interventions focusing on hospitals, rural areas, and patients who face challenges on the day of their diagnosis.
참고문헌 (23)
- "Antiretroviral drugs for treating pregnant women and preventing HIV infection in infants: recommendations for a public health approach (2010 version)"[URL]
- "Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection: recommendations for a public health approach" (2013)[URL]
- "Current practices to increase uptake, retention and adherence for option B+ in Malawi" (2014)[URL]
- World Health Organization, "Programmatic update: use of antiretroviral drugs for treating pregnant women and preventing HIV infection in infants: executive summary", World Health Organization, 4~ (2012)
- Besada D, "The case for option B and optional B+ : ensuring that South Africa’s commitment to eliminating mother-to-child transmission of HIV becomes a reality", South Afr J HIV Med, 13, pp.178~181 (2012)
- Awittor RJ, "Adherence to antiretroviral therapy (ART) among HIV positive women at antiretroviral centers in Tema", pp.2012
- "Towards universal access: scaling up priority HIV/AIDS interventions in the health sector" (2010)[URL]
- "Development of a multi-method tool to measure ART adherence in resource-constrained settings: the South Africa experience" (2007)[URL]
- Nachega JB, "Adherence to antiretroviral therapy during and after pregnancy in low-income, middle-income, and high-income countries: a systematic review and meta-analysis", AIDS, 26, pp.2039~2052 (2012)
- "Global report: UNAIDS report on the global AIDS epidemic 2013"[URL]
- "Guidelines for prevention of mother-to-child transmission of HIV in Ethiopia" (2007)[URL]
- Ekama SO, "Pattern and determinants of antiretroviral drug adherence among Nigerian pregnant women", J Pregnancy, 2012, pp.851810~ (2012)
- Belayihun B, "Antiretroviral Treatment adherence rate and associated factors among people living with HIV in Dubti Hospital, Afar Regional State, East Ethiopia", Int Sch Res Notices, 2015, pp.187360~ (2015)
- Ebuy H, "Level of adherence and predictors of adherence to the Option B+ PMTCT programme in Tigray, northern Ethiopia", Int J Infect Dis, 33, pp.123~129 (2015)
- Bello SI, "HIV", AIDS patients’ adherence to antiretroviral therapy in Sobi Specialist Hospital, Ilorin, Nigeria, 2011, pp.11, 17~25
- Igwegbe AO, "Prevalence and determinants of non-adherence to antiretroviral therapy among HIV- positive pregnant women in Nnewi, Nigeria", Int J Med Med Sci, 2, pp.238~245 (2010)
- Demessie R, "Knowledge and adherence to antiretroviral therapy among adult people living with HIV", AIDS at Tikur Anbessa Specialized Hospital, Ethiopia, 2014, pp.3, 320~330
- Markos E, "Adherence to ART in PLWHA at Yirgalem Hospital, South Ethiopia", Ethiop J Health Dev, 22, pp.174~179 (2008)
- Okawa S, "Longitudinal adherence to antiretroviral drugs for preventing mother-to-child transmission of HIV in Zambia", BMC Pregnancy Childbirth, 15, pp.258~ (2015)
- Mbirimtengerenji ND, "Factors that influence anti-retroviral therapy adherence among women in Lilongwe urban health centres, Malawi", World J AIDS, 3, pp.16~25 (2013)
- Bitew BD, "Determinants of none-adherence to antiretroviral therapy among HIV-infected adults in Arba Minch General Hospital, Gamo Gofa Zone, Southern Ethiopia: a case control study", Am J Health Res, 2, pp.234~240 (2014)
- "‘Option B+’ women are at increased risk of loss to follow-up after starting HIV treatment" (2013)[URL]
- Kamuyango AA, "One-year outcomes of women started on antiretroviral therapy during pregnancy before and after the implementation of Option B+ in Malawi : a retrospective chart review", World J AIDS, 4, pp.332~337 (2014)