Korea HIV/AIDS Cohort Study: study design and baseline characteristics
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초록
The number of persons infected by HIV/AIDS has consistently increased in Korea since the first case of HIV/AIDS infection in 1985 and reached 15,208 by 2016. About 1,100 new patients with HIV/ AIDS infections have emerged every year since 2013. In Korea, the Korea HIV/AIDS Cohort Study was established for the evidenced-based prevention, treatment, and effective management of patients infected with human immunodeficiency virus (HIV) in December 2006. This study monitored 1,438 patients, who accounted for about 10% of all patients with HIV/AIDS in Korea, for 10 years with the following aims: (1) to develop an administrative system for the establishment of a HIV/AIDS cohort-based study; (2) to standardize methodologies and the case report forms; and (3) to standardize multi-cohort data and develop a data cleaning method. This study aims to monitor at least 1,000 patients (excluding those for whom investigation had been completed) per year (estimated number of patients who can be monitored by January 2018: 939). By December 2016, the sex distribution was 93.3% for men, and 6.7% for women (gender ratio, 13.9:1.0), and 98.9% of all participants were Korean. More than 50.0% of the participants were confirmed as HIV positive after 2006. This study reports competitive, long-term research that aimed to develop policies for the prevention of chronic infectious diseases for patients with HIV. The data collected over the last decade will be used to develop indices for HIV treatment and health promotion.
Abstract
The number of persons infected by HIV/AIDS has consistently increased in Korea since the first case of HIV/AIDS infection in 1985 and reached 15,208 by 2016. About 1,100 new patients with HIV/ AIDS infections have emerged every year since 2013. In Korea, the Korea HIV/AIDS Cohort Study was established for the evidenced-based prevention, treatment, and effective management of patients infected with human immunodeficiency virus (HIV) in December 2006. This study monitored 1,438 patients, who accounted for about 10% of all patients with HIV/AIDS in Korea, for 10 years with the following aims: (1) to develop an administrative system for the establishment of a HIV/AIDS cohort-based study; (2) to standardize methodologies and the case report forms; and (3) to standardize multi-cohort data and develop a data cleaning method. This study aims to monitor at least 1,000 patients (excluding those for whom investigation had been completed) per year (estimated number of patients who can be monitored by January 2018: 939). By December 2016, the sex distribution was 93.3% for men, and 6.7% for women (gender ratio, 13.9:1.0), and 98.9% of all participants were Korean. More than 50.0% of the participants were confirmed as HIV positive after 2006. This study reports competitive, long-term research that aimed to develop policies for the prevention of chronic infectious diseases for patients with HIV. The data collected over the last decade will be used to develop indices for HIV treatment and health promotion.
참고문헌 (26)
- Nelson KE, "Infectious disease epidemiology", pp.651~722 (2014), Jones & Barlett Learning
- Montagnier L, "Lymphadenopathy-associated virus: from molecular biology to pathogenicity", Ann Intern Med, 103, pp.689~693 (1985)[DOI]
- Barre-Sinoussi F, "Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). 1983", Science, 220, pp.868~871 (1983)[DOI]
- Friedman AH, "Cytomegalovirus retinitis and immunodeficiency in homosexual males", Lancet, 1, pp.958~ (1982)
- Self PC, "Acquired immunodeficiency syndrome (AIDS) and the epidemic growth of its literature", Scientometrics, 17, pp.49~60 (1989)[DOI]
- Centers for Disease Control and Prevention, "Pneumocystis pneumonia--Los Angeles. 1981", MMWR Morb Mortal Wkly Rep, 45, pp.729~733 (1996)
- Detels R, "The multicenter AIDS Cohort Study, 1983 to…", Public Health, 126, pp.196~198 (2012)[DOI]
- Coutinho RA, "The Amsterdam Cohort Studies on HIV infection and AIDS", J Acquir Immune Defic Syndr Hum Retrovirol, 17(Suppl 1), pp.S4~S8 (1998)[DOI]
- Swiss HIV Cohort Study, "Cohort profile: the Swiss HIV Cohort study", Int J Epidemiol, 39, pp.1179~1189 (2010)[DOI]
- Ledergerber B, "Clinical progression and virological failure on highly active antiretroviral therapy in HIV-1 patients: a prospective cohort study. Swiss HIV Cohort Study", Lancet, 353, pp.863~868 (1999)[DOI]
- Lichtenstein B, "Chronic sorrow in the HIV-positive patient: issues of race, gender, and social support", AIDS Patient Care STDS, 16, pp.27~38 (2002)[DOI]
- Egger M, "Prognosis of HIV-1-infected patients starting highly active antiretroviral therapy: a collaborative analysis of prospective studies", Lancet, 360, pp.119~129 (2002)[DOI]
- Grangeiro A, "The HIV-Brazil cohort study: design, methods and participant characteristics", PLoS One, 9, pp.e95673~ (2014)[DOI]
- "Joint United Nations Programme on HIV/AIDS. UNAIDS data 2017"[URL]
- "HIV/AIDS notifications in Korea"[URL]
- JuneMyungKim, "Epidemiology and Clinical Features of HIV Infection", AIDS in Korea, 2003, pp.44(3), 363~370[DOI]
- Sung H, "High frequency of drug resistance mutations in human immunodeficiency virus type 1-infected Korean patients treated with HAART", AIDS Res Hum Retroviruses, 23, pp.1223~1229 (2007)[DOI]
- 송준영, "치료 경험이 없는 HIV 감염자에서의 항바이러스제 일차 내성 분석: 한국HIV", AIDS 코호트 연구, 2009, pp.41(4), 230~232[DOI]
- 김민정, "Trend of CD4+ Cell Counts at Diagnosis and Initiation of Highly Active Antiretroviral Therapy (HAART): Korea HIV", AIDS Cohort Study, 1992-2015, 2017, pp.49(2), 101~108[DOI]
- 김민정, "Causes of HIV Drug Non-Adherence in Korea: Korea HIV", AIDS Cohort Study, 2006-2015, 2017, pp.49(3), 213~218[DOI]
- Kee MK, "Anxiety and depressive symptoms among patients infected with human immunodeficiency virus in South Korea", AIDS Care, 27, pp.1174~1182 (2015)[DOI]
- Park KS, "Impact of depression and anxiety on cardiovascular risk using Framingham score among HIV positivie patients: an analysis of the Korea Cohort HIV", AIDS Study, Hanyang University, 2015
- 김윤정, "Opportunistic diseases among HIV-infected patients: a multicenter-nationwide Korean HIV", AIDS cohort study, 2006 to 2013, 2016, pp.31(5), 953~960[DOI]
- 오동현, "Metabolic Complications among Korean Patients with HIV Infection: The Korea HIV", AIDS Cohort Study, 2017, pp.32(8), 1268~1274[DOI]
- 김용찬, "Human Immunodeficiency Virus (HIV) and Hepatitis Virus Coinfection among HIV-Infected Korean Patients: The Korea HIV", AIDS Cohort Study, 2017, pp.49(4), 268~274[DOI]
- 김은진, "The Prevalence and Risk Factors of Renal Insufficiency among Korean HIV-Infected Patients: The Korea HIV", AIDS Cohort Study, 2017, pp.49(3), 194~204[DOI]