Comparison of HIV characteristics across 3 datasets: the Korea HIV/AIDS Cohort Study prospective, retrospective, and national reporting system
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OBJECTIVES: The Korea HIV/AIDS Cohort Study has been conducted prospectively for 18 years. However, it faces limitations in representing the entire population of patients with human immunodeficiency virus (HIV) in Korea. To address these limitations and validate the study design, we analyzed characteristics across several HIV datasets.METHODS: We compared epidemiological and clinical characteristics from 3 datasets: the Korea HIV/AIDS Cohort Study (dataset 1, n=1,562), retrospective cohort data (dataset 2, n=2,665), and the national HIV reporting system of the Korea Disease Control and Prevention Agency (KDCA) (dataset 3, n=17,403).RESULTS: The demographic characteristics of age, sex, and age at HIV diagnosis did not differ significantly across datasets. However, dataset 3 contained a higher proportion of patients diagnosed after 2008 (69.5%) than the other datasets. Regarding transmission routes, same-sex contact accounted for a greater proportion of dataset 1 (59.8%) compared to datasets 2 (20.9%) and 3 (32.6%). The proportion of patients with CD4 T-cell counts below 200/mm3 at HIV diagnosis was higher in datasets 1 (39.4%) and 2 (33.3%) compared to dataset 3 (16.3%). Initial HIV viral load measurements were not obtained for dataset 3.CONCLUSIONS: The Korea HIV/AIDS Cohort Study demonstrated representativeness regarding the demographic characteristics of Korean patients. Of the sources, dataset 1 contained the most data on transmission routes. While the KDCA data encompassed all HIV patients, it lacked detailed clinical information. To improve the representativeness of the Korea HIV/AIDS Cohort Study, we propose expanding and revising the cohort design and enrolling more patients who have been recently diagnosed.
Abstract
OBJECTIVES: The Korea HIV/AIDS Cohort Study has been conducted prospectively for 18 years. However, it faces limitations in representing the entire population of patients with human immunodeficiency virus (HIV) in Korea. To address these limitations and validate the study design, we analyzed characteristics across several HIV datasets.METHODS: We compared epidemiological and clinical characteristics from 3 datasets: the Korea HIV/AIDS Cohort Study (dataset 1, n=1,562), retrospective cohort data (dataset 2, n=2,665), and the national HIV reporting system of the Korea Disease Control and Prevention Agency (KDCA) (dataset 3, n=17,403).RESULTS: The demographic characteristics of age, sex, and age at HIV diagnosis did not differ significantly across datasets. However, dataset 3 contained a higher proportion of patients diagnosed after 2008 (69.5%) than the other datasets. Regarding transmission routes, same-sex contact accounted for a greater proportion of dataset 1 (59.8%) compared to datasets 2 (20.9%) and 3 (32.6%). The proportion of patients with CD4 T-cell counts below 200/mm3 at HIV diagnosis was higher in datasets 1 (39.4%) and 2 (33.3%) compared to dataset 3 (16.3%). Initial HIV viral load measurements were not obtained for dataset 3.CONCLUSIONS: The Korea HIV/AIDS Cohort Study demonstrated representativeness regarding the demographic characteristics of Korean patients. Of the sources, dataset 1 contained the most data on transmission routes. While the KDCA data encompassed all HIV patients, it lacked detailed clinical information. To improve the representativeness of the Korea HIV/AIDS Cohort Study, we propose expanding and revising the cohort design and enrolling more patients who have been recently diagnosed.
참고문헌 (14)
- Choi BY, "Korea HIV", AIDS Cohort Study : study design and baseline characteristics, 2018, pp.40, e2018023~
- Choi Y, "Epidemiological characteristics of HIV infected Korean : Korea HIV", AIDS Cohort Study, 2019, pp.41, e2019037~
- Nohr EA, "How to investigate and adjust for selection bias in cohort studies", Acta Obstet Gynecol Scand, 97, pp.407~416 (2018)[DOI]
- Greenland S, "Response and follow-up bias in cohort studies", Am J Epidemiol, 106, pp.184~187 (1977)[DOI]
- Rothman KJ, "Modern epidemiology", pp.134~137 (2008), Wolters Kluwer
- Song JY, "Comparison of HIV-infected patients’ characteristics and clinical outcomes between cohort-dependent and independent patients : Korean HIV cohort study", J Acquir Immune Defic Syndr, 57, pp.e61~e63 (2011)[DOI]
- Kim JH, "Comparison of characteristics and survival between prospective and retrospective Korea human immunodeficiency virus", acquired immune deficiency syndrome cohort studies, 2019, pp.51, 393~398
- 2021 HIV, "AIDS notification in the Republic of Korea", Korea Disease Control and Prevention Agency (KDCA), 2022
- Saag MS, "Antiretroviral drugs for treatment and prevention of HIV infection in adults : 2020 recommendations of the International Antiviral Society-USA panel", JAMA, 324, pp.1651~1669 (2020)[DOI]
- Euser AM, "Cohort studies : prospective versus retrospective", Nephron Clin Pract, 113, pp.c214~c217 (2009)[DOI]
- Vandenbroucke JP, "Observational research, randomised trials, and two views of medical science", PLoS Med, 5, pp.e67~ (2008)[DOI]
- Vandenbroucke JP, "Prospective or retrospective : what’s in a name?", BMJ, 302, pp.249~ (1991)[DOI]
- Lau B, "Interval and clinical cohort studies : epidemiological issues", AIDS Res Hum Retroviruses, 23, pp.769~776 (2007)[DOI]
- Ryu DR, "Introduction to the medical research using national health insurance claims database", Ewha Med J, 40, pp.66~70 (2017)[DOI]