Exploring the associations between cardiovascular health measured with the CANHEART model and early cognitive impairment in a middle-aged population in Korea
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
OBJECTIVES: Both cardiovascular health (CVH) and inflammation are associated with cognition, and inflammation is also associated with CVH. However, limited information has been reported on these factors in the Korean population. The objective of our study was to investigate the influence of inflammation on the association between CVH and cognition using a cross-sectional design. METHODS: Data were obtained from the Cardiovascular and Metabolic Diseases Etiology Research Center baseline study. Participants who completed fasting serum analysis, questionnaires, and cognitive function tests were included in the analysis, whereas those with a history of autoimmune disease were excluded. The CVH in Ambulatory Care Research Team health index metrics, including smoking, physical activity, healthy diet, obesity, history of hypertension, and diabetes, were used to assess CVH. Cognitive function was evaluated with the Korean version of the Mini-Mental State Estimation for Dementia Screening. Inflammatory status was assessed based on a high-sensitivity C-reactive protein (hs-CRP) test. RESULTS: Among 2,622 total participants (mean age, 57.2 years; 1,792 women), 13%, 58%, and 29% had poor, intermediate, and ideal CVH, respectively. Logistic regression analysis demonstrated that CVH was significantly associated with cognitive function only in women. A stratified analysis showed that cognitive impairment due to CVH was not associated with hs-CRP levels. When the same analyses were conducted for each CVH component, the only component affecting the association was hypertension history in men. CONCLUSIONS: CVH is not significantly associated with cognitive decline in the middle-aged Korean population. Inflammation did not play a significant modifying role in this relationship.
Abstract
OBJECTIVES: Both cardiovascular health (CVH) and inflammation are associated with cognition, and inflammation is also associated with CVH. However, limited information has been reported on these factors in the Korean population. The objective of our study was to investigate the influence of inflammation on the association between CVH and cognition using a cross-sectional design. METHODS: Data were obtained from the Cardiovascular and Metabolic Diseases Etiology Research Center baseline study. Participants who completed fasting serum analysis, questionnaires, and cognitive function tests were included in the analysis, whereas those with a history of autoimmune disease were excluded. The CVH in Ambulatory Care Research Team health index metrics, including smoking, physical activity, healthy diet, obesity, history of hypertension, and diabetes, were used to assess CVH. Cognitive function was evaluated with the Korean version of the Mini-Mental State Estimation for Dementia Screening. Inflammatory status was assessed based on a high-sensitivity C-reactive protein (hs-CRP) test. RESULTS: Among 2,622 total participants (mean age, 57.2 years; 1,792 women), 13%, 58%, and 29% had poor, intermediate, and ideal CVH, respectively. Logistic regression analysis demonstrated that CVH was significantly associated with cognitive function only in women. A stratified analysis showed that cognitive impairment due to CVH was not associated with hs-CRP levels. When the same analyses were conducted for each CVH component, the only component affecting the association was hypertension history in men. CONCLUSIONS: CVH is not significantly associated with cognitive decline in the middle-aged Korean population. Inflammation did not play a significant modifying role in this relationship.
참고문헌 (41)
- You Joung Kim, "Prevalence and Trends of Dementia in Korea: A Systematic Review and Meta-Analysis", Journal of Korean Medical Science, 29(7), pp.903~912 (2014), 대한의학회
- Brodaty H, "Psychosocial effects on carers of living with persons with dementia", Aust N Z J Psychiatry, 24, pp.351~361 (1990)
- Leifer BP, "Early diagnosis of Alzheimer’s disease: clinical and economic benefits", J Am Geriatr Soc, 51(5 Suppl Dementia), pp.S281~S288 (2003)
- Weller J, "Current understanding of Alzheimer’s disease diagnosis and treatment", F1000Res, 7 (2018)
- Doraiswamy PM, "Long-term effects of rivastigmine in moderately severe Alzheimer’s disease: does early initiation of therapy offer sustained benefits?", Prog Neuropsychopharmacol Biol Psychiatry, 26, pp.705~712 (2002)
- Frisoni GB, "Strategic roadmap for an early diagnosis of Alzheimer’s disease based on biomarkers", Lancet Neurol, 16, pp.661~676 (2017)
- Sabia S, "Association of ideal cardiovascular health at age 50 with incidence of dementia: 25 year follow-up of Whitehall II cohort study", BMJ, 366, pp.l4414~ (2019)
- Samieri C, "Association of cardiovascular health level in older age with cognitive decline and incident dementia", JAMA, 320, pp.657~664 (2018)
- Chi GC, "Inflammatory biomarkers predict domain-specific cognitive decline in older adults", J Gerontol A Biol Sci Med Sci, 72, pp.796~803 (2017)
- Clearfield MB, "C-reactive protein : a new risk assessment tool for cardiovascular disease", J Am Osteopath Assoc, 105, pp.409~416 (2005)
- Cook NR, "The effect of including C-reactive protein in cardiovascular risk prediction models for women", Ann Intern Med, 145, pp.21~29 (2006)
- Bruunsgaard H, "Physical activity and modulation of systemic lowlevel inflammation", J Leukoc Biol, 78, pp.819~835 (2005)
- Rubinow DR, "Cortisol hypersecretion and cognitive impairment in depression", Arch Gen Psychiatry, 41, pp.279~283 (1984)
- Noble JM, "Association of C-reactive protein with cognitive impairment", Arch Neurol, 67, pp.87~92 (2010)
- Song IU, "Relationship between the hs-CRP as non-specific biomarker and Alzheimer’s disease according to aging process", Int J Med Sci, 12, pp.613~617 (2015)
- Wersching H, "Serum C-reactive protein is linked to cerebral microstructural integrity and cognitive function", Neurology, 74, pp.1022~1029 (2010)
- Folsom AR, "American Heart Association’s Life’s Simple 7 : avoiding heart failure and preserving cardiac structure and function", Am J Med, 128, pp.970~976 (2015)
- Jeon YJ, "Does serum vitamin D level affect the association between cardiovascular health and cognition? Results of the Cardiovascular and Metabolic Diseases Etiology Research Center(CMERC)study", Eur J Neurol, 28, pp.48~55 (2021)
- Maclagan LC, "The CANHEART health index : a tool for monitoring the cardiovascular health of the Canadian population", CMAJ, (186), pp.180~187 (2014)
- 심지선, "Cardiovascular and Metabolic Diseases Etiology Research Center (CMERC) cohort: study protocol and results of the first 3 years of enrollment", Epidemiology and Health, 39, pp.1~9 (2017), 한국역학회[DOI]
- Tae Hui Kim, "Korean Version of Mini Mental Status Examination for Dementia Screening and Its Short Form", PSYCHIATRY INVESTIGATION, 7(2), pp.102~108 (2010), 대한신경정신의학회
- 전민영, "Validity and Reliability of Korean Version of International Physical Activity Questionnaire Short Form in the Elderly", Korean Journal of Family Medicine, 33(3), pp.144~151 (2012), 대한가정의학회[DOI]
- Sato N, "Aging and dementia", Nihon Rinsho, 74, pp.1518~1525 (2016)
- Lövdén M, "Education and cognitive functioning across the life span", Psychol Sci Public Interest, 21, pp.6~41 (2020)
- Lee S, "The relation of education and income to cognitive function among professional women", Neuroepidemiology, 26, pp.93~101 (2006)
- Liu H, "Marital status and cognitive impairment in the United States : evidence from the National Health and Aging Trends Study", Ann Epidemiol, 38, pp.28~34 (2019)
- Koch M, "Alcohol consumption and risk of dementia and cognitive decline among older adults with or without mild cognitive impairment", JAMA Netw Open, 2, pp.e1910319~ (2019)
- Hughes D, "Association of blood pressure lowering with incident dementia or cognitive impairment : a systematic review and metaanalysis", JAMA, 323, pp.1934~1944 (2020)
- Panza F, "Total cholesterol levels and the risk of mild cognitive impairment and Alzheimer’s disease", J Am Geriatr Soc, 55, pp.133~135 (2007)
- Xue M, "Diabetes mellitus and risks of cognitive impairment and dementia : a systematic review and meta-analysis of 144 prospective studies", Ageing Res Rev, 55, pp.100944~ (2019)
- von Hundelshausen P, "Chronic inflammation and atherosclerosis", Dtsch Med Wochenschr, 138, pp.1839~1844 (2013)
- Yarchoan M, "Association of plasma C-reactive protein levels with the diagnosis of Alzheimer’s disease", J Neurol Sci, 333, pp.9~12 (2013)
- Fernandes A, "C-reactive protein as a predictor of mild cognitive impairment conversion into Alzheimer’s disease dementia", Exp Gerontol, 138, pp.111004~ (2020)
- "Korea health statistics 2018: Korea National Health and Nutrition Examination Survey (KNHANES VII-3)" (2019)[URL]
- Elmadfa I, "European nutrition and health report 2009", Forum Nutr, 62, pp.1~405 (2009)
- Głąbska D, "Fruit and vegetable intake and mental health in adults : a systematic review", Nutrients, 12, pp.115~ (2020)
- Crump K, "The potential effects of recall bias and selection bias on the epidemiological evidence for the carcinogenicity of glyphosate", Risk Anal, 40, pp.696~704 (2020)
- Hackler E 3rd, "Racial differences in cardiovascular biomarkers in the general population", J Am Heart Assoc, 8, pp.e012729~ (2019)
- Stearns JC, "Ethnic and diet-related differences in the healthy infant microbiome", Genome Med, 9, pp.32~ (2017)
- Li W, "Racial differences in eating patterns and food purchasing behaviors among urban older women", J Nutr Health Aging, 21, pp.1190~1199 (2017)
- Chi-Young Lee, "Measurement of Socioeconomic Position in Research on Cardiovascular Health Disparities in Korea: A Systematic Review", 예방의학회지, 52(5), pp.281~291 (2019), 대한예방의학회[DOI]