본문 바로가기
KERD
논문KCI 등재

중·고령자의 추정 심폐체력과 인지기능 저하 발생과의 연관성: 고령화연구패널조사의 12년간 추적조사를 바탕으로

Association of Estimated Cardiorespiratory Fitness with the Incidence of Cognitive Impairment in Middle-Aged and Older Adults: Based on 12 Years Follow-Up Data from the Korean Longitudinal Study of Aging

강현식|이인환|송문구
한국운동생리학회|2021.02|운동과학 (Exercise Science)|제30권 제1호|pp. 16-24

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

중·고령자인지장애종단연구Cognitive impairmentLongitudinal studyMiddle-aged and older adults추정 심폐체력Estimated cardiorespiratory fitness

초록

PURPOSE:This study investigated association of estimated cardiorespiratory fitness (eCRF) with the incidence of cognitive impairment in Korean middle-aged and older adults. METHODS:Total of 4,239 subjects (53% women) aged ≥45 years, who participated in the Korean longitudinal study of aging (KLoSA) were included. Participants were classified into 4 categories from the lowest quartile to the highest quartile based on eCRF distribu¬tions. Korean version of mini-mental status examination (K-MMSE) was used to assessed mild cognitive impairment (MCI) and severe cognitive impairment (SCI). Cox’s proportional regression analyses were used to determine the hazard ratio (HR) and 95% confidence interval (CI) of eCRF categories for having MCI and SCI. RESULTS: During 12-years of follow-up, there were 736 (17.4%) and 272 (6.4%) cases of incidence from MCI and SCI, respectively. In women, compared to the quartile 1 group (reference, HR=1), the quartile 4 group had significantly lower HRs of having incidence of MCI/SCI (HR=0.72, 95% CI=0.55-0.94, p=.015) and MCI (HR=0.73, 95% CI=0.54-0.99, p=.045). However, in men, eCRF was not associated with incidence of cognitive impairment. CONCLUSIONS:The current findings suggest that eCRF may be an independent predictor of cognitive impairment in middle-aged and older women.

Abstract

PURPOSE:This study investigated association of estimated cardiorespiratory fitness (eCRF) with the incidence of cognitive impairment in Korean middle-aged and older adults. METHODS:Total of 4,239 subjects (53% women) aged ≥45 years, who participated in the Korean longitudinal study of aging (KLoSA) were included. Participants were classified into 4 categories from the lowest quartile to the highest quartile based on eCRF distribu¬tions. Korean version of mini-mental status examination (K-MMSE) was used to assessed mild cognitive impairment (MCI) and severe cognitive impairment (SCI). Cox’s proportional regression analyses were used to determine the hazard ratio (HR) and 95% confidence interval (CI) of eCRF categories for having MCI and SCI. RESULTS: During 12-years of follow-up, there were 736 (17.4%) and 272 (6.4%) cases of incidence from MCI and SCI, respectively. In women, compared to the quartile 1 group (reference, HR=1), the quartile 4 group had significantly lower HRs of having incidence of MCI/SCI (HR=0.72, 95% CI=0.55-0.94, p=.015) and MCI (HR=0.73, 95% CI=0.54-0.99, p=.045). However, in men, eCRF was not associated with incidence of cognitive impairment. CONCLUSIONS:The current findings suggest that eCRF may be an independent predictor of cognitive impairment in middle-aged and older women.

참고문헌 (40)

  1. United nations, "World population prospects, the 2015 revision, key findings and advance tables", United Nations, 30~32 (2015)
  2. Ministry of health and welfare, "Korean dementia observatory 2019", Ministry of Health and Welfare, 35~80 (2020)
  3. Nyberg L, "Memory aging and brain maintenance", Trends in Cogn Sci, 16(5), pp.292~305 (2012)
  4. Bae JB, "Impact of mild cognitive impairment on mortality and cause of death in the elderly", J Alzheimers Dis, 64(2), pp.607~616 (2018)
  5. Schenning KJ, "Sex and genetic differences in postoperative cognitive dysfunction : a longitudinal cohort analysis", Biol Sex Differ, 10(1), pp.14~ (2019)
  6. Marengoni A, "Socioeconomic status during lifetime and cognitive impairment no-dementia in late life : the population-based aging in the chianti area(InCHIANTI)study", J Alzheimers Dis, 24(3), pp.559~568 (2011)
  7. Ogawa S, "Nutritional management of older adults with cognitive decline and dementia", Geriatr Gerontol Int, 14(Suppl 2), pp.17~22 (2014)
  8. Hagger-Johnson G, "Combined impact of smoking and heavy alcohol use on cognitive decline in early old age : whitehall II prospective cohort study", Br J Psychiatry, 203(2), pp.120~125 (2013)
  9. Laurin D, "Physical activity and risk of cognitive impairment and dementia in elderly persons", Arch Neurol, 58(3), pp.498~504 (2001)
  10. Kyung Hwan Kim, "The Relationship between Handgrip Strength and Cognitive Function in Elderly Koreans over 8 Years: A Prospective Population-Based Study Using Korean Longitudinal Study of Ageing", Korean Journal of Family Medicine, 40(1), pp.9~15 (2019), 대한가정의학회[DOI]
  11. Farrell SW, "The relationship between cardiorespiratory fitness and montreal cognitive assessment scores in older adults", Gerontology, 64(5), pp.440~445 (2018)
  12. Lee DC, "Mortality trends in the general population : the importance of cardiorespiratory fitness", J Psychopharmacol, 24(4 Suppl), pp.27~35 (2010)
  13. Howden EJ, "Cardiorespiratory fitness and cardiovascular burden in chronic kidney disease", J Sci Med Sport, 18(4), pp.492~497 (2015)
  14. Al-Mallah MH, "Cardiorespiratory fitness and cardiovascular disease prevention : an update", Curr Atheroscler Rep, 20(1), pp.1~ (2018)
  15. Kawakami R, "Longterm impact of cardiorespiratory fitness on type 2 diabetes incidence : a cohort study of japanese men", J Epidemiol, 28(5), pp.266~273 (2018)
  16. Schultz SA, "Cardiorespiratory fitness attenuates the influence of amyloid on cognition", J Int Neuropsychol Soc, 21(10), pp.841~850 (2015)
  17. Schmalhofer ML, "Sex-specific associations of brain-derived neurotrophic factor and cardiorespiratory fitness in the general population", Biomolecules, 9(10), pp.630~ (2019)
  18. Pentikäinen H, "Cardiorespiratory fitness and cognition : longitudinal associations in the FINGER study", J Alzheimers Dis, 68(3), pp.961~968 (2019)
  19. Defina LF, "The association between midlife cardiorespiratory fitness levels and later-life dementia : a cohort study", Ann Intern Med, 158(3), pp.162~168 (2013)
  20. Wendell CR, "Cardiorespiratory fitness and accelerated cognitive decline with aging", J Gerontol A Biol Sci Med Sci, 69(4), pp.455~462 (2014)
  21. 송문구, "노인의 추정 심폐체력과 정신건강과의 연관성 분석", 운동과학, 28(4), pp.330~338 (2019), 한국운동생리학회
  22. Peterman JE, "Comparison of non-exercise cardiorespiratory fitness prediction equations in apparently healthy adults", Eur J Prev Cardiol, pp.2047487319881242~ (2019)
  23. Artero EG, "Longitudinal algorithms to estimate cardiorespiratory fitness : associations with nonfatal cardiovascular disease and disease-specific mortality", J Am Coll Cardiol, 63(21), pp.2289~2296 (2014)
  24. Folstein MF, "“Mini-mental state”. A practi-cal method for grading the cognitive state of patients for the clinician", J Psychiatr Res, 12(3), pp.189~198 (1975)
  25. Kang YW, "A validity study on the korean minimental state examination(K-MMSE)in dementia patients", J Korean Neurol Assoc, 15(2), pp.300~308 (1997)
  26. Tombaugh TN, "The mini-mental state examination : a comprehensive review", J Am Geriatr Soc, 40(9), pp.922~935 (1992)
  27. Baynard T, "The role of body habitus in predicting cardiorespiratory fitness : the FRIEND registry", Int J Sports Med, 37(11), pp.863~869 (2016)
  28. Garnvik LE, "Physical activity, cardiorespiratory fitness, and cardiovascular outcomes in individuals with atrial fibrillation : the HUNT study", Eur Heart J, 41(15), pp.1467~1475 (2020)
  29. Centers for Disease Control and Prevention (CDC), "Cigarette smoking among adults--United States, 1992, and changes in the definition of current cigarette smoking", MMWR Morb Mortal Wkly Rep, 43(19), pp.342~346 (1994)
  30. Xi B, "Relationship of alcohol consumption to all-cause, cardiovascular, and cancer-related mortality in U.S. adults", J Am Coll Cardiol, 70(8), pp.913~922 (2017)
  31. Won CW, "The development of korean activities of daily living(K-ADL)and korean instrumental activities of daily living(K-IADL)scale", J Korean Geriatr Soc, 6(2), pp.107~120 (2002)
  32. Sattler C, "Physical fitness as a protective factor for cognitive impairment in a prospective population-based study in Germany", J Alzheimers Dis, 26(4), pp.709~718 (2011)
  33. Kawagoe T, "Associations among executive function, cardiorespiratory fitness, and brain network properties in older adults", Sci Rep, 7, pp.40107~ (2017)
  34. Zhu N, "Cardiorespiratory fitness and cognitive function in middle age : the CARDIA study", Neurology, 82(15), pp.1339~1346 (2014)
  35. Tari AR, "Temporal changes in cardiorespiratory fitness and risk of dementia incidence and mortality : a population-based prospective cohort study", Lancet Public Health, 4(11), pp.e565~e574 (2019)
  36. Boots EA, "Cardiorespiratory fitness is associated with brain structure, cognition, and mood in a middle-aged cohort at risk for Alzheimer's disease", Brain Imaging Behav, 9(3), pp.639~649 (2015)
  37. Hörder H, "Midlife cardiovascular fitness and dementia : A 44-year longitudinal population study in women", Neurology, 90(15), pp.e1298~e1305 (2018)
  38. Atkinson HH, "The relationship between cognitive function and physical performance in older women : results from the women's health initiative memory study", J Gerontol A Biol Sci Med Sci, 65(3), pp.300~306 (2010)
  39. Koran MEI, "Sex differences in the association between AD biomarkers and cognitive decline", Brain Imaging and Behav, 11(1), pp.205~213 (2017)
  40. Guo Y, "Sex differentials in relationships between functional fitness and cognitive performance in older adults : a canonical correlation analysis", Sci Rep, 8(1), pp.4146~ (2018)

이 간행물의 다른 논문 (15건)

운동과학(Exerc Sci)과 코로나바이러스감염증-19김창선pp. 1-2The Impacts of Exercise-Intervention on the Prevention and Treatment of Some Types of Cancer서한교pp. 3-7The Effects of Foot Reflexology on the Physical Symptoms of Cancer Patients연영란, 김혜영, 곽이섭pp. 8-15국민체력100 유아기 체력측정도구의 측정-재측정 신뢰도 연구윤은선, 박수현, 김태완, 이혜수, 송홍선, 한태경pp. 25-338주 아세트산 투여가 마우스 지구력과 골격근의 지방대사에 미치는 영향오성희, 주정선, 최경오, 이동원pp. 34-42
원문 보기