The association between glaucoma and all-cause mortality in middle-aged and elderly Chinese people: results from the China Health and Retirement Longitudinal Study
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
OBJECTIVES: This population-based, prospective cohort study investigated the association between glaucoma and mortality in older adults. METHODS: Participants aged 45 years or older at baseline (47.9% male) were enrolled in 2011 for the China Health and Retirement Longitudinal Study (CHARLS). All-cause mortality was observed during 7 years of follow-up. The baseline data were collected in the 2011 CHARLS, and participants were followed up for 7 years (until 2018). The risk of all-cause mortality was investigated using Cox proportional-hazards regression with age as the time scale, adjusting for significant risk factors and comorbid conditions. RESULTS: Among the 14,803 participants included, the risk of all-cause death was significantly higher among people with glaucoma than among those without glaucoma, after adjustment for other confounders (hazard ratio [HR], 1.46; 95% confidence interval [CI], 1.04 to 2.03). In a subgroup analysis based on the mean age of death, among those who were 75 years and older (n=1,231), the risk of all-cause death was significantly higher in patients with glaucoma than in those without glaucoma (HR, 1.89; 95% CI, 1.24 to 1.89). CONCLUSIONS: Participants with glaucoma had a higher risk of all-cause mortality, especially those aged 75 years and above. Our findings revealed potential mechanisms underlying an association between glaucoma and all-cause mortality. They also highlighted the importance of glaucoma management to prevent premature death in middle-aged and older adults.
Abstract
OBJECTIVES: This population-based, prospective cohort study investigated the association between glaucoma and mortality in older adults. METHODS: Participants aged 45 years or older at baseline (47.9% male) were enrolled in 2011 for the China Health and Retirement Longitudinal Study (CHARLS). All-cause mortality was observed during 7 years of follow-up. The baseline data were collected in the 2011 CHARLS, and participants were followed up for 7 years (until 2018). The risk of all-cause mortality was investigated using Cox proportional-hazards regression with age as the time scale, adjusting for significant risk factors and comorbid conditions. RESULTS: Among the 14,803 participants included, the risk of all-cause death was significantly higher among people with glaucoma than among those without glaucoma, after adjustment for other confounders (hazard ratio [HR], 1.46; 95% confidence interval [CI], 1.04 to 2.03). In a subgroup analysis based on the mean age of death, among those who were 75 years and older (n=1,231), the risk of all-cause death was significantly higher in patients with glaucoma than in those without glaucoma (HR, 1.89; 95% CI, 1.24 to 1.89). CONCLUSIONS: Participants with glaucoma had a higher risk of all-cause mortality, especially those aged 75 years and above. Our findings revealed potential mechanisms underlying an association between glaucoma and all-cause mortality. They also highlighted the importance of glaucoma management to prevent premature death in middle-aged and older adults.
참고문헌 (49)
- Jonas JB, "Glaucoma", Lancet, 390, pp.2183~2193 (2017)
- Tham YC, "Validity of a new optic disc grading software for use in clinical and epidemiological research", Clin Exp Ophthalmol, 41, pp.842~852 (2013)
- Song P, "National and subnational prevalence and burden of glaucoma in China : a systematic analysis", J Glob Health, 7, pp.020705~ (2017)
- Weinreb RN, "The pathophysiology and treatment of glaucoma : a review", JAMA, 311, pp.1901~1911 (2014)
- Foster PJ, "Glaucoma in China : how big is the problem", Br J Ophthalmol, 85, pp.1277~1282 (2001)
- He M, "Angle-closure glaucoma in east Asian and European people. Different diseases?", Eye (Lond), 20, pp.3~12 (2006)
- Bourne R, "New systematic review methodology for visual impairment and blindness for the 2010 global burden of disease study", Ophthalmic Epidemiol, 20, pp.33~39 (2013)
- Tham YC, "Global prevalence of glaucoma and projections of glaucoma burden through 2040 : a systematic review and meta-analysis", Ophthalmology, 121, pp.2081~2090 (2014)
- Leske MC, "Glaucoma and mortality: a connection?", Ophthalmology, 110, pp.1473~1475 (2003)
- Xu L, "Glaucoma and mortality in the Beijing Eye Study", Eye(Lond), 22, pp.434~438 (2008)
- Chou CL, "Risks of all-cause mortality and major kidney events in patients with new-onset primary open-angle glaucoma : a nationwide long-term cohort study in Taiwan", BMJ Open, 8, pp.e021270~ (2018)
- Khanna RC, "Glaucoma-associated long-term mortality in a rural cohort from India : the andhra pradesh eye disease study", Br J Ophthalmol, 102, pp.1477~1482 (2018)
- Akbari M, "The association of primary open-angle glaucoma with mortality : a meta-analysis of observational studies", Arch Ophthalmol, 127, pp.204~210 (2009)
- Sundqvist J, "Open-angle glaucoma and mortality : a long-term follow-up study", Acta Ophthalmol, 96, pp.e1038~e1039 (2018)
- Kühn T, "Glaucoma and mortality risk : findings from a prospective population-based study", Sci Rep, 11, pp.11771~ (2021)
- Pache M, "A sick eye in a sick body? Systemic findings in patients with primary open-angle glaucoma", Surv Ophthalmol, 51, pp.179~212 (2006)
- Zhao Y, "Cohort profile : the China Health and Retirement Longitudinal Study(CHARLS)", Int J Epidemiol, 43, pp.61~68 (2014)
- Zhao X, "Associations of sensory impairment and cognitive function in middle-aged and older Chinese population : the China Health and Retirement Longitudinal Study", J Glob Health, 11, pp.08008~ (2021)
- Xie D, "Comparison of self-reports and biomedical measurements on hypertension and diabetes among older adults in China", BMC Public Health, 20, pp.1664~ (2020)
- Wang L, "Association of glaucoma with 10-year mortality in a population-based longitudinal study in urban Southern China : the Liwan Eye Study", BMJ Open, 11, pp.e040795~ (2021)
- Xu L, "Mortality and ocular diseases : the Beijing Eye Study", Ophthalmology, 116, pp.732~738 (2009)
- Hiller R, "High intraocular pressure and survival : the framingham studies", Am J Ophthalmol, 128, pp.440~445 (1999)
- Egge K, "Survival of glaucoma patients", Acta Ophthalmol Scand, 77, pp.397~401 (1999)
- Thorburn W, "Survival time among patients with glaucomatous visual field defects", Acta Ophthalmol(Copenh), 61, pp.728~730 (1983)
- Lee DJ, "Glaucoma and survival : the national health interview survey 1986-1994", Ophthalmology, 110, pp.1476~1483 (2003)
- Lee AJ, "Open-angle glaucoma and cardiovascular mortality : the Blue Mountains Eye Study", Ophthalmology, 113, pp.1069~1076 (2006)
- Grødum K, "Glaucoma and mortality", Graefes Arch Clin Exp Ophthalmol, 242, pp.397~401 (2004)
- Sun J, "Prevalence and risk factors for primary open-angle glaucoma in a rural northeast China population: a population-based survey in Bin County, Harbin", Eye(Lond), 26, pp.283~291 (2012)
- Song W, "Prevalence of glaucoma in a rural northern china adult population : a population-based survey in Kailu County, Inner Mongolia", Ophthalmology, 118, pp.1982~1988 (2011)
- Borger PH, "Is there a direct association between age-related eye diseases and mortality? The Rotterdam Study", Ophthalmology, 110, pp.1292~1296 (2003)
- Unterlauft JD, "Role of the aging visual system in glaucoma", Ophthalmologe, 114, pp.108~113 (2017)
- Lee SY, "Association between glaucoma surgery and all-cause and cause-specific mortality among elderly patients with glaucoma : a nationwide population-based cohort study", Sci Rep, 11, pp.17055~ (2021)
- Stein JD, "Association between the use of glaucoma medications and mortality", Arch Ophthalmol, 128, pp.235~240 (2010)
- Wu SY, "Open-angle glaucoma and mortality : the Barbados Eye Studies", Arch Ophthalmol, 126, pp.365~370 (2008)
- Stewart WC, "Serum lipid physiology and the influence of glaucoma medications", Surv Ophthalmol, 43, pp.233~244 (1998)
- French DD, "Glaucoma medications and mortality : a retrospective cohort study", Ann Epidemiol, 20, pp.917~923 (2010)
- Müskens RP, "Topical beta-blockers and mortality", Ophthalmology, 115, pp.2037~2043 (2008)
- Nucci C, "Links among glaucoma, neurodegenerative, and vascular diseases of the central nervous system", Prog Brain Res, 221, pp.49~65 (2015)
- Rim TH, "Increased stroke risk among patients with open-angle glaucoma : a 10-year follow-up cohort study", Br J Ophthalmol, 102, pp.338~343 (2018)
- Su CW, "Association of neovascular glaucoma with risk of stroke : a population-based cohort study", J Ophthalmol, 2017, pp.1851568~ (2017)
- Ho JD, "Open-angle glaucoma and the risk of stroke development : a 5-year population-based follow-up study", Stroke, 40, pp.2685~2690 (2009)
- Lai SW, "Glaucoma may be a non-memory manifestation of alzheimer’s disease in older people", Int Psychogeriatr, pp.1~7 (2017)
- Sen S, "Neurodegeneration in alzheimer’s disease and glaucoma: overlaps and missing links", Eye(Lond), 34, pp.1546~1553 (2020)
- Wostyn P, "Alzheimer’s disease and glaucoma : look-alike neurodegenerative diseases", Alzheimers Dement, 15, pp.600~601 (2019)
- MacAskill MR, "Eye movements in neurodegenerative diseases", Curr Opin Neurol, 29, pp.61~68 (2016)
- Lin IC, "Glaucoma, alzheimer’s disease, and parkinson’s disease : an 8-year population-based follow-up study", PLoS One, 9, pp.e108938~ (2014)
- Lai SW, "Glaucoma correlates with increased risk of Parkinson’s disease in the elderly : a national-based cohort study in Taiwan", Curr Med Res Opin, 33, pp.1511~1516 (2017)
- Sun J, "Prevalence and risk factors of glaucoma among Chinese people from the China Health and Retirement Longitudinal Study", J Glaucoma, 31, pp.789~795 (2022)
- Xianwen Shang, "Associations of vision impairment and eye diseases with frailty in community-dwelling older adults: a nationwide longitudinal study in China", British Journal of Ophthalmology, 108(2), pp.310~316 (2022), BMJ[DOI]