Mupirocin Ointment Prevents Early Post-Tympanostomy Tube Otorrhea: A Preliminary Study
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Background and Objectives: The most common complication of tympanostomy tube (T-tube) insertion is the development of postoperative otorrhea. Post-tympanostomy tube otorrhea (PTTO) is defined as active drainage through an existing T-tube. Many surgeons routinely use topical antibiotics as prophylaxis against early PTTO. Mupirocin calcium ointment is a topical antimicrobial agent with broad-spectrum antimicrobial activity against many Gram-positive organisms. This study evaluated the clinical effectiveness of topical mupirocin ointment in reducing early PTTO. Subjects and Methods: The study included 98 ears (67 patients, mean age 32.9 years) that had a T-tube inserted because of chronic middle ear effusion or atelectatic otitis media. A Paparella type-I polyethylene-tube coated with mupirocin was inserted through the tympanostomy. Patients were instructed not to use otic drops or any other medications. All patients were seen by day 14 postoperatively. Results: Early PTTO occurred in one case (1.5%). No early PTTO was seen with a middle ear effusion. Nineteen children were treated under general anesthesia; none developed early PTTO. Conclusions: Insertion of a T-tube coated with mupirocin ointment could be effective at preventing early PTTO.
Abstract
Background and Objectives: The most common complication of tympanostomy tube (T-tube) insertion is the development of postoperative otorrhea. Post-tympanostomy tube otorrhea (PTTO) is defined as active drainage through an existing T-tube. Many surgeons routinely use topical antibiotics as prophylaxis against early PTTO. Mupirocin calcium ointment is a topical antimicrobial agent with broad-spectrum antimicrobial activity against many Gram-positive organisms. This study evaluated the clinical effectiveness of topical mupirocin ointment in reducing early PTTO. Subjects and Methods: The study included 98 ears (67 patients, mean age 32.9 years) that had a T-tube inserted because of chronic middle ear effusion or atelectatic otitis media. A Paparella type-I polyethylene-tube coated with mupirocin was inserted through the tympanostomy. Patients were instructed not to use otic drops or any other medications. All patients were seen by day 14 postoperatively. Results: Early PTTO occurred in one case (1.5%). No early PTTO was seen with a middle ear effusion. Nineteen children were treated under general anesthesia; none developed early PTTO. Conclusions: Insertion of a T-tube coated with mupirocin ointment could be effective at preventing early PTTO.
참고문헌 (13)
- Gates GA, "Post-tympanostomy otorrhea", Laryngoscope, 96, pp.630~634 (1986)
- Hochman J, "Post-tympanostomy tube otorrhea: a meta-analysis", Otolaryngol Head Neck Surg, 135, pp.8~11 (2006)
- Furukawa M, "Clinical effectiveness of ototopical application of mupirocin ointment in methicillin-resistant Staphylococcus aureus otorrhea", Otol Neurotol, 29, pp.676~678 (2008)
- Henkel T, "Emergence of resistance during mupirocin treatment: is it a problem in clinical practice?", J Chemother, 11, pp.331~337 (1999)
- Scott BA, "Posttympanostomy otorrhea: the efficacy of canal preparation", Laryngoscope, 102, pp.1103~1107 (1992)
- Giebink GS, "Predictors for post operative otorrhea following tympanostomy tube insertion", Arch Otolaryngol Head Neck Surg, 118, pp.491~494 (1992)
- Kinsella JB, "Tympanostomy tubes and early post-operative otorrhea", Int J Pediatr Otorhinolaryngol, 30, pp.111~114 (1994)
- Shinkwin CA, "Per-operative antibiotic", steroid prophylaxis of tympanostomy tube otorrhoea: chemical or mechanical effect?, 1996, pp.110, 531~533
- Gross RD, "Saline irrigation in the prevention of otorrhea after tympanostomy tube placement", Laryngoscope, 110(2 Pt 1), pp.246~249 (2000)
- Jung H, "Current bacteriology of chronic otitis media with effusion: High rate of nosocomial infection and decreased antibiotic sensitivity", JOURNAL OF INFECTION, 59(0), pp.308~316 (2009), W B SAUNDERS CO LTD
- Debruyne F, "Otorrhea during transtympanal ventilation", Am J Otol, 9, pp.316~317 (1988)
- Balkany TJ, "A prospective study of infection following tympanostomy and tube insertion", Am J Otol, 4, pp.288~291 (1983)
- Golz A, "Prophylactic treatment after ventilation tube insertion: comparison of various methods", Otolaryngol Head Neck Surg, 119, pp.117~120 (1998)