Clinical Safety and Efficacy of Autologous Bone Marrow-Derived Mesenchymal Stem Cell Transplantation in Sensorineural Hearing Loss Patients
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초록
Stem cell transplantation represents a promising therapy for several degenerating and necroticdiseases. In several animal studies, we could find hearing restoration after inoculation of themesenchymal stem cells' as well as mesenchymal stem cells' differentiation of hair cells andspiral ganglion. But until now, no clinical study has been reported directly for the human being. In this pilot studies, we applied mesenchymal stem cells to human beings trans-venously. Although we verified the safety of the autologous bone marrow stem cell transplantationin sensorineural hearing loss patients but we could not achieve significant improvementin hearing.
Abstract
Stem cell transplantation represents a promising therapy for several degenerating and necroticdiseases. In several animal studies, we could find hearing restoration after inoculation of themesenchymal stem cells' as well as mesenchymal stem cells' differentiation of hair cells andspiral ganglion. But until now, no clinical study has been reported directly for the human being. In this pilot studies, we applied mesenchymal stem cells to human beings trans-venously. Although we verified the safety of the autologous bone marrow stem cell transplantationin sensorineural hearing loss patients but we could not achieve significant improvementin hearing.
참고문헌 (14)
- Gordon-Salant S, "Hearing loss and aging: new research findings and clinical implications", J Rehabil Res Dev, 42(4 Suppl 2), pp.9~24 (2005)[DOI]
- Appollonio I, "Effects of sensory aids on the quality of life and mortality of elderly people: a multivariate analysis", Age Ageing, 25, pp.89~96 (1996)[DOI]
- Kil K, "Regenerative efficacy of mesenchymal stromal cells from human placenta in sensorineural hearing loss", Int J Pediatr Otorhinolaryngol, 91, pp.72~81 (2016)[DOI]
- Guo W, "Profiles of the auditory epithelia related microRNA expression in neonatal and adult rats", Eur J Med Res, 19, pp.48~ (2014)[DOI]
- Suzuka Y, "Retrograde cochlear neuronal degeneration in human subjects", Acta Otolaryngol Suppl, 450, pp.1~20 (1988)
- Sinkkonen ST, "Intrinsic regenerative potential of murine cochlear supporting cells", Sci Rep, 1, pp.26~ (2011)[DOI]
- Giordano A, "From the laboratory bench to the patient's bedside: an update on clinical trials with mesenchymal stem cells", J Cell Physiol, 211, pp.27~35 (2007)[DOI]
- Tamura T, "Transplantation of neural stem cells into the modiolus of mouse cochleae injured by cisplatin", Acta Otolaryngol Suppl, pp.65~68 (2004)
- Spicer SS, "Differentiation of inner ear fibrocytes according to their ion transport related activity", Hear Res, 56, pp.53~64 (1991)[DOI]
- Adams JC, "Immunocytochemical traits of type IV fibrocytes and their possible relations to cochlear function and pathology", J Assoc Res Otolaryngol, 10, pp.369~382 (2009)[DOI]
- Kasagi H, "Mesenchymal stem cell transplantation to the mouse cochlea as a treatment for childhood sensorineural hearing loss", Int J Pediatr Otorhinolaryngol, 77, pp.936~942 (2013)[DOI]
- 조용범, "Transplantation of Neural Differentiated Human Mesenchymal Stem Cells into the Cochlea of an Auditory-neuropathy Guinea Pig Model", Journal of Korean Medical Science, 26(4), pp.492~498 (2011), 대한의학회
- Kamiya K, "Assembly of the cochlear gap junction macromolecular complex requires connexin 26", J Clin Invest, 124, pp.1598~1607 (2014)[DOI]
- Hernandez D, "Electrical stimulation promotes cardiac differentiation of human induced pluripotent stem cells", Stem Cells Int, 2016, pp.1718041~ (2016)