Effects of Caffeine on Auditory- and Vestibular-Evoked Potentials in Healthy Individuals: A Double-Blind Placebo-Controlled Study
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Background and Objectives:The blockage of adenosine receptors by caffeine changes the levels of neurotransmitters. These receptors are present in all parts of the body, including the auditory and vestibular systems. This study aimed to evaluate the effect of caffeine on evoked potentials using auditory brainstem responses (ABRs) and cervical vestibular-evoked myogenic potentials (cVEMPs) in a double-blind placebo-controlled study. Subjects and Methods: Forty individuals (20 females and 20 males; aged 18-25 years) were randomly assigned to two groups: the test group (consuming 3 mg/kg pure caffeine powder with little sugar and dry milk in 100 mL of water), and the placebo group (consuming only sugar and dry milk in 100 mL water as placebo). The cVEMPs and ABRs were recorded before and after caffeine or placebo intake. Results: A significant difference was observed in the absolute latencies of I and III (p<0.010), and V (p<0.001) and in the inter-peak latencies of III–V and I–V (p<0.001) of ABRs wave. In contrast, no significant difference was found in cVEMP parameters (P13 and N23 latency, threshold, P13-N23 amplitude, and amplitude ratio). The mean amplitudes of P13-N23 showed an increase after caffeine ingestion. However, this was not significant compared with the placebo group (p>0.050). Conclusions: It seems that the extent of caffeine’s effects varies for differently evoked potentials. Latency reduction in ABRs indicates that caffeine improves transmission in the central brain auditory pathways. However, different effects of caffeine on auditory- and vestibular-evoked potentials could be attributed to the differences in sensitivities of the ABR and cVEMP tests.
Abstract
Background and Objectives:The blockage of adenosine receptors by caffeine changes the levels of neurotransmitters. These receptors are present in all parts of the body, including the auditory and vestibular systems. This study aimed to evaluate the effect of caffeine on evoked potentials using auditory brainstem responses (ABRs) and cervical vestibular-evoked myogenic potentials (cVEMPs) in a double-blind placebo-controlled study. Subjects and Methods: Forty individuals (20 females and 20 males; aged 18-25 years) were randomly assigned to two groups: the test group (consuming 3 mg/kg pure caffeine powder with little sugar and dry milk in 100 mL of water), and the placebo group (consuming only sugar and dry milk in 100 mL water as placebo). The cVEMPs and ABRs were recorded before and after caffeine or placebo intake. Results: A significant difference was observed in the absolute latencies of I and III (p<0.010), and V (p<0.001) and in the inter-peak latencies of III–V and I–V (p<0.001) of ABRs wave. In contrast, no significant difference was found in cVEMP parameters (P13 and N23 latency, threshold, P13-N23 amplitude, and amplitude ratio). The mean amplitudes of P13-N23 showed an increase after caffeine ingestion. However, this was not significant compared with the placebo group (p>0.050). Conclusions: It seems that the extent of caffeine’s effects varies for differently evoked potentials. Latency reduction in ABRs indicates that caffeine improves transmission in the central brain auditory pathways. However, different effects of caffeine on auditory- and vestibular-evoked potentials could be attributed to the differences in sensitivities of the ABR and cVEMP tests.
참고문헌 (28)
- Ruxton CHS, "The impact of caffeine on mood, cognitive function, performance and hydration: a review of benefits and risks", Nutrition Bulletin, 33, pp.15~25 (2008)
- Nehlig A, "Caffeine and the central nervous system:mechanisms of action, biochemical, metabolic and psychostimulant effects", Brain Res Brain Res Rev, 17, pp.139~170 (1992)
- Nawrot P, "Effects of caffeine on human health", Food Addit Contam, 20, pp.1~30 (2003)
- Martin PY, "effects of caffeine on persuasion and attitude change : the role of secondary tasks in manipulating systematic message processing", Eur J Soc Psychol, 37, pp.320~338 (2007)
- Tarnopolsky MA, "Effect of caffeine on the neuromuscular system--potential as an ergogenic aid", Appl Physiol Nutr Metab, 33, pp.1284~1289 (2008)
- Bobbin RP, "Caffeine and ryanodine demonstrate a role for the ryanodine receptor in the organ of Corti", Hear Res, 174, pp.172~182 (2002)
- Dixit A, "Effect of caffeine on central auditory pathways : an evoked potential study", Hear Res, 220, pp.61~66 (2006)
- Pan J, "Acute caffeine effect on repeatedly measured P300", Environl Health Prev Med, 5, pp.13~17 (2000)
- Barry RJ, "Caffeine effects on ERPs and performance in an auditory Go", NoGo task, 2007, pp.118, 2692~2699
- Shalini S, "Effect of caffeine on evoked potentials", IOSR J Dent Med Sci, 2, pp.43~48 (2012)
- Felipe L, "Evaluation of the caffeine effect in the vestibular test", Braz J Otorhinolaryngol, 71, pp.758~762 (2005)
- McNerney K, "The influence of caffeine on calorics and cervical vestibular evoked myogenic potentials(cVEMPs)", J Am Acad Audiol, 25, pp.261~267 (2014)
- Enriquez A, "Effects of caffeine on postural stability", Int Tinnitus J, 15, pp.161~163 (2009)
- McNerney KM, "The influence of caffeine on rotary chair and oculomotor testing", J Am Acad Audiol, 29, pp.587~595 (2018)
- de Sousa AMA, "Effect of caffeine on cervical vestibularevoked myogenic potential in healthy individuals", Braz J Otorhinolaryngol, 80, pp.226~230 (2014)
- Souza MEDCA, "Effect of caffeine on vestibular evoked myogenic potential : a systematic review with meta-analysis", Braz J Otorhinolaryngol, 84, pp.381~388 (2018)
- Litman RE, "Smooth pursuit eye movements in schizophrenia : effects of neuroleptic treatment and caffeine", Psychopharmacol Bull, 25, pp.473~478 (1989)
- Pilli R, "An electrooculographic method for the evaluation of psychotropic drugs on saccadic eye movements in healthy subjects", Int J Psychol Stud, 4, pp.75~87 (2012)
- Vlajkovic SM, "Differential distribution of adenosine receptors in rat cochlea", Cell Tissue Res, 328, pp.461~471 (2007)
- Ricci A, "Cyclic AMP modulates sensory-neural communication at the vestibular end organ", Brain Res, 565, pp.78~84 (1991)
- Seidl R, "A taurine and caffeine-containing drink stimulates cognitive performance and well-being", Amino Acids, 19, pp.635~642 (2000)
- Kamimori GH, "Caffeine improves reaction time, vigilance and logical reasoning during extended periods with restricted opportunities for sleep", Psychopharmacology(Berl), 232, pp.2031~2042 (2015)
- Santos VG, "Caffeine reduces reaction time and improves performance in simulated-contest of taekwondo", Nutrients, 6, pp.637~649 (2014)
- Dixit A, "Evaluation of cognitive brain functions in caffeine users : a P3 evoked potential study", Indian J Physiol Pharmacol, 50, pp.175~180 (2006)
- Deslandes AC, "Effects of caffeine on visual evoked potential(P300)and neuromotor performance", Arq Neuropsiquiatr, 62(2B), pp.385~390 (2004)
- Kawamura N, "Effects of caffeine on event-related potentials : comparison of oddball with single-tone paradigms", Psychiatry Clin Neurosci, 50, pp.217~221 (1996)
- Lorist MM, "Caffeine, fatigue, and cognition", Brain Cogn, 53, pp.82~94 (2003)
- Taghavi SMR, "Effects of short-term caffeine consumption on speech and sound reception in individuals with normal hearing", Aud Vestib Res, 27, pp.150~156 (2018)