본문 바로가기
KERD
논문KCI 등재

Optimized TOF-PET detector using scintillation crystal array for brain imaging

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류원자력공학

초록

Research groups in the field of PET instrumentation are studying time-of-flight(TOF) technology to improve the signal-to-noise ratio of PET images. Scintillation light transport and collection plays an important role in improving the coincidence resolving time(CRT) of PET detector based on a pixelated crystal array. Four crystal arrays were designed by the different optical reflection configuration such as external reflectors and surface treatment on the CRT and compared with the light output, energy resolution and CRT. The design proposed in the study was composed of 8  8 LYSO crystal array consisted of 3  3  15 mm3 pixels. The entrance side was roughened while the other five surfaces were polished. Four sides of all crystal pixels were wrapped with ESR-film, and the entrance surface was covered by Teflon-tape. The design provided an excellent timing resolution of 210 ps and improved the CRT by 16% compared to the conventional method using a polishing treatment and ESR-film. This study provided a method for improving the light output and CRT of a pixelated scintillation crystal-based brain TOF PET detector. The proposed configuration might be an attractive detector design for TOF brain PET requiring fast timing performance with high cost-effectiveness

Abstract

Research groups in the field of PET instrumentation are studying time-of-flight(TOF) technology to improve the signal-to-noise ratio of PET images. Scintillation light transport and collection plays an important role in improving the coincidence resolving time(CRT) of PET detector based on a pixelated crystal array. Four crystal arrays were designed by the different optical reflection configuration such as external reflectors and surface treatment on the CRT and compared with the light output, energy resolution and CRT. The design proposed in the study was composed of 8  8 LYSO crystal array consisted of 3  3  15 mm3 pixels. The entrance side was roughened while the other five surfaces were polished. Four sides of all crystal pixels were wrapped with ESR-film, and the entrance surface was covered by Teflon-tape. The design provided an excellent timing resolution of 210 ps and improved the CRT by 16% compared to the conventional method using a polishing treatment and ESR-film. This study provided a method for improving the light output and CRT of a pixelated scintillation crystal-based brain TOF PET detector. The proposed configuration might be an attractive detector design for TOF brain PET requiring fast timing performance with high cost-effectiveness

참고문헌 (30)

  1. J. H. Jung, "Development of PET", MRI with insertable PET for simultaneous PET and MR imaging of human brain, 2015, pp.42, 2354~2363
  2. K. J. Hong, "A prototype MR insertable brain PET using tileable GAPD arrays", Med. Phys, 40, pp.1~12 (2013)
  3. Nam-Yong Lee, "Simulation studies on depth of interaction effect correction using a Monte Carlo computed system matrix for brain positron emission tomography", Computer Methods and Programs in Biomedicine, 108(2), pp.820~831 (2012), Elsevier BV[DOI]
  4. Han-Back Shin, "Conceptual Study of Brain Dedicated PET Improving Sensitivity", 의학물리, 27(4), pp.236~240 (2016), 한국의학물리학회[DOI]
  5. K. Wienhard, "The ECAT HRRT : performance and first clinical application of the new high resolution research tomograph", IEEE Trans. Nucl. Sci, 49, pp.104~110 (2002)
  6. C. Catana, "Development of dedicated brain PET imaging devices : recent advances and future perspectives", J. Nucl. Med, 60, pp.1044~1052 (2019)
  7. S. Majewski, "HelmetPET: A Silicon Photomultiplier Based Wearable Brain Imager", IEEE Nucl. Sci. Symp. Conf. Rec, IEEE NSS, RTSD, pp.2011[DOI]
  8. C. R. Schmidtlein, "Initial performance studies of a wearable brain positron emission tomography camera based on autonomous thin-film digital Geiger avalanche photodiode arrays", J. Med. Imag, 4, pp.011003~ (2017)
  9. J. S. Karp, "Benefit of time-offlight in PET : experimental and clinical results", J. Nucl. Med, 48, pp.462~470 (2008)
  10. H. Thoen, "Influence of detector pixel size, TOF resolution and DOI on image quality in MRcompatible whole-body PET", Phys. Med. Biol, 58, pp.6459~6479 (2013)
  11. S. Vandenberghe, "Recent developments in time-of-flight PET", Eur. J. Nucl. Med. Mol. Imag. Phys, 3 (2016)
  12. M. Conti, "Focus on time-of-flight PET : the benefits of improved time resolution", Eur. J. Nucl. Med. Mol. Imag. Phys, 38, pp.1147~1157 (2011)
  13. E. Yoshida, "245 ps-TOF brain-dedicated PET prototype with a hemispherical detector arrangement", Phys. Med. Biol, 65 (2020)
  14. S. W. Lee, "Development of a multiplexed readout with high position resolution for positron emission tomography", Nucl. Instrum. Methods Phys. Res. A, 850, pp.42~47 (2017)
  15. M. Conti, "The new opportunities for high time resolution clinical TOF PET", Clin. Transl. Imaging, 7 (2019)
  16. S. Gundacker, "State of the art timing in TOF-PET detectors with LuAG, GAGG and L(Y)SO scintillators of various sizes coupled to FBK-SiPMs", J. Instrum, 11 (2016)
  17. E. Berg, "Optimizing light transport in scintillation crystals for time-of-flight PET : an experimental and optical Monte Carlo simulation study", Biomed. Opt Express, 6, pp.2220~2230 (2015)
  18. C. Kim, "Effect of Scintillation Crystal Surface Finish in the Light Sharing TOF PET Detector", IEEE Nucl. Sci. Symp. Conf. Rec, IEEE NSS, RTSD, pp.2016[DOI]
  19. C. M. Lavelle, "Approaches for single channel large area silicon photomultiplier array readout", AIP Adv, 9, pp.5088503~ (2019)
  20. V. Nadig, "Evaluation of the PETsys TOFPET2ASIC in multi-channel coincidence experiments", Eur. J. Nucl. Med. Mol. Imag. Phys, 30 (2021)
  21. K. B. Kim, "Analog and digital signal processing method using multi-time-over-threshold and FPGA for PET", Med. Phys, 45, pp.4104~4111 (2018)
  22. T. Nagano, "Timing Resolution Dependence on MPPC Geometry and Performance", IEEE Nucl. Sci. Symp. Med. Imag. Conf. (2013)
  23. C. -Y. Liu, "Improved event positioning in a gamma ray detector using an iterative position-weighted centre-of-gravity algorithm", Phys. Med. Biol, 58, pp.N189~ (2013)[DOI]
  24. H. T. Leem, "Performance evaluation of a sub-millimeter spatial resolution PET detector module using a digital silicon photomultiplier coupled LGSO array", Nucl. Instrum. Methods Phys. Res. A, 846, pp.18~22 (2017)
  25. H. -J. Choe, "Development of capacitive multiplexing circuit for SiPM-based time-of-flight(TOF)PET detector", Phys. Med. Biol, 62, pp.N120~ (2017)[DOI]
  26. M. Aykac, "Timing performance of Hi-Rez detector for time-of-flight(TOF)PET", IEEE Trans. Nucl. Sci, 53, pp.1084~1089 (2006)
  27. E. Roncali, "Modelling the transport of optical photons in scintillation detectors for diagnostic and radiotherapy imaging", Phys. Med. Biol, 62, pp.R207~ (2017)[DOI]
  28. E. Roncali, "An integrated model of scintillatorreflector properties for advanced simulations of optical transport", Phys. Med. Biol, 62, pp.4811~4830 (2017)
  29. D. J. V. Elburg, "Comparison of acrylic polymer adhesive tapes and silicone optical grease in light sharing detectors for positron emission tomography", Phys. Med. Biol, 63 (2018)
  30. E. Lorincz, "Modeling and optimization of scintillator arrays for PET detectors", IEEE Trans. Nucl. Sci, 57, pp.48~54 (2010)

관련 논문AI추천

Effects of reflector, surface treatment, and length of scintillation crystal on the performance of TOF-DOI PET detector with dual-ended readout최용, 윤조현, 이상원, 정지웅, 정진호한국원자력학회 · Nuclear Engineering and Technology2024 · 제56권 제7호Insights and simulation of metascintillator-based brain PET systems to enhance ToF capabilityBenlloch J.M., Bonifacio D.A.B., Gonzalez A.J., Konstantinou G., Latella R., Lecoq P., Murata H.M.한국원자력학회 · Nuclear Engineering and Technology2025 · 제57권 제5호Comparison of UV-enhanced SiPM technologies for estimating 511 keV photon arrival time using BGO Cherenkov LuminescenceGola Alberto, Gonzalez-Montoro Andrea, Levin Craig S., Merzi Stefano, Pourashraf Shirin한국원자력학회 · Nuclear Engineering and Technology2025 · 제57권 제4호Low-noise fast-response readout circuit to improve coincidence time resolution최용, 김연경, 백승헌, 이상원, 정지웅, 정진호한국원자력학회 · Nuclear Engineering and Technology2024 · 제56권 제4호Preliminary study on scintillation pixel position determination through deep learning of a two-layer DOI detector이승재, 조병두한국원자력학회 · Nuclear Engineering and Technology2025 · 제57권 제6호A study on the positioning of fine scintillation pixels in a positron emission tomography detector through deep learning of simulation data이승재, 조병두한국원자력학회 · Nuclear Engineering and Technology2024 · 제56권 제5호

이 간행물의 다른 논문 (15건)