Systematic analysis for the thermal stability assessment of 166Ho production using HANARO: An in silico study
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Medical radioisotopes (RIs) are widely used in the diagnosis and treatment of tumors. Theranostic RIs, such as 131I, 166Ho, 177Lu, and 186Re, are particularly notable for their ability to enable diagnosis and treatment simultaneously. Conducting irradiation tests using the High-flux Advanced Neutron Application Reactor (HANARO), a 30-MW multipurpose research reactor, enables the production of these medical RIs. Prior to irradiation tests, it is crucial to assess whether they affect the thermal stability of irradiated materials and the thermal-hydraulic safety of HANARO. This study systematically investigates the feasibility of 166Ho production using the isotope production irradiation hole of HANARO, focusing on thermal stability. The nuclear heating rates of the RI production target and RI capsule are calculated using MCNP6, and the calculated nuclear heating rates are used for three-dimensional heat transfer analysis using COMSOL Multiphysics. Under the assumed conditions in this study, 166Ho production did not compromise the thermal stability of the RI production target and RI capsule; consequently, the thermal-hydraulic safety criteria of HANARO could be satisfied. This study can serve as a valuable reference for evaluating the thermal stability of irradiated materials and the thermalhydraulic safety of HANARO, which must be performed before irradiation tests using HANARO
Abstract
Medical radioisotopes (RIs) are widely used in the diagnosis and treatment of tumors. Theranostic RIs, such as 131I, 166Ho, 177Lu, and 186Re, are particularly notable for their ability to enable diagnosis and treatment simultaneously. Conducting irradiation tests using the High-flux Advanced Neutron Application Reactor (HANARO), a 30-MW multipurpose research reactor, enables the production of these medical RIs. Prior to irradiation tests, it is crucial to assess whether they affect the thermal stability of irradiated materials and the thermal-hydraulic safety of HANARO. This study systematically investigates the feasibility of 166Ho production using the isotope production irradiation hole of HANARO, focusing on thermal stability. The nuclear heating rates of the RI production target and RI capsule are calculated using MCNP6, and the calculated nuclear heating rates are used for three-dimensional heat transfer analysis using COMSOL Multiphysics. Under the assumed conditions in this study, 166Ho production did not compromise the thermal stability of the RI production target and RI capsule; consequently, the thermal-hydraulic safety criteria of HANARO could be satisfied. This study can serve as a valuable reference for evaluating the thermal stability of irradiated materials and the thermalhydraulic safety of HANARO, which must be performed before irradiation tests using HANARO
참고문헌 (24)
- H. Kim, "Design characteristics and startup tests of HANARO", J. Nucl. Sci. Technol, 33, pp.527~538 (1996)
- K. N. Choo, "Contribution of HANARO irradiation technologies to national nuclear R&D", Nucl. Eng. Technol, 46, pp.501~512 (2014)
- S. K. Lee, "Development of fission 99Mo production process using HANARO", Nucl. Eng. Technol, 52, pp.1517~1523 (2020)
- G. M. Sun, "An investigation of excretion of calcium from female mice ingested with boron by using neutron activation analysis", Nucl. Eng. Technol, 52, pp.2581~2584 (2020)
- T. Kim, "Thermalhydraulic safety analysis of radioisotope production in HANARO using MCNP6 and COMSOL multiphysics : a feasibility study", Nucl. Eng. Technol, 55, pp.3996~4001 (2023)
- C. H. Yeong, "Therapeutic radionuclides in nuclear medicine : current and future prospects", J. Zhejiang Univ. -Sci. B, 15, pp.845~863 (2014)
- A. Yordanova, "Theranostics in nuclear medicine practice", Onco. Targets, Therapy, 10, pp.4821~4828 (2017)
- N. J. M. Klaassen, "The various therapeutic applications of the medical isotope holmium-166: a narrative review", EJNMMI Radiopharm, Chem, 4, pp.1~26 (2019)
- S. Lahiri, "Production of 166Ho through 164Dy(n,γ)165Dy (n,γ)166Dy(β− )166Ho and separation of 166Ho", Appl. Radiat. Isot, 61, pp.1157~1161 (2004)
- Analysis on the Detailed Heat Generation Rate for the HANARO, "B. C. Lee", Korea Atomic Energy Research Institute, ~, pp.KAERI (2008), TR-3643[DOI]
- "LiveChart of nuclides"[URL]
- F. Ahsan, "Experimental measurement of thermal diffusivity, conductivity and specific heat capacity of metallic powders at room and high temperatures", Powder Technol, 374, pp.648~657 (2020)
- J. Romano, "Temperature distribution and melt geometry in laser and electron-beam melting processes – a comparison among common materials", Addit. Manuf, 8, pp.1~11 (2015)
- T. Goorley, "Initial MCNP6 release overview", Nucl. Technol, 180, pp.298~315 (2012)
- Evaluation of Nuclear Heating Rate by Delayed Gamma Rays from Fission Products of HANARO, "B. G. Park", Korea Atomic Energy Research Institute, ~, pp.KAERI (2018), TR-7239[DOI]
- T. Noh, "Estimation of nuclear heating by delayed gamma rays from radioactive structural materials of HANARO", Nucl. Eng. Technol, 50, pp.446~452 (2018)
- Release of ENDF, "BVIII. 0-based ACE Data Files", J. L. Conlin, 2018, LA-UR-18-24034
- E. J. F. Dickinson, "COMSOL Multiphysics®: finite element software for electrochemical analysis. A mini-review", Electrochem. Commun, 40, pp.71~74 (2014)
- "Material property data" (2016)[URL]
- V. D. Risovany, "Dysprosium titanate as an absorber material for control rods", J. Nucl. Mater, 281, pp.84~89 (2000)
- R. B. Firestone, "Database of Prompt Gamma Rays from Slow Neutron Capture for Elemental Analysis", International Atomic Energy Agency (2004)
- Q. Pan, "Rapid diagnostic method for transplutonium isotope production in high flux reactors", Nucl. Sci. Tech, 34, pp.44~ (2023)
- Q. Zhao, "Neutron spectrum optimization for Cf-252 production based on key nuclides analysis", Radiat. Phys. Chem, 214, pp.111294~ (2024)
- Q. Pan, "High-resolution neutronics model for 238Pu production in high-flux reactors", Nucl. Sci. Tech, 35, pp.88~ (2024)