Investigation of the Biodegradable Mechanism of Pure Magnesium Using Electrochemical Impedance Spectroscopy Technique
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In this study, electrochemical impedance spectroscopy (EIS) was used to examine the changes in theelectrochemical properties of biodegradable pure magnesium implanted into Sprague-Dawley rats for threedays. The in vivo test results were compared with those of the in vitro tests carried out in Hank's, dilutesaline and simulated body fluid (SBF) solutions. The in vitro corrosion rates were 20~1700 fold higher,as compared to the in vivo corrosion rates. This discrepancy is caused by biomolecule adsorption on thesurface, which prevents the transport of water into the magnesium surface on in vivo testing. Among thein vitro experimental conditions, the corrosion rate in SBF solution had the least difference from the invivo implanted specimen.
Abstract
In this study, electrochemical impedance spectroscopy (EIS) was used to examine the changes in theelectrochemical properties of biodegradable pure magnesium implanted into Sprague-Dawley rats for threedays. The in vivo test results were compared with those of the in vitro tests carried out in Hank's, dilutesaline and simulated body fluid (SBF) solutions. The in vitro corrosion rates were 20~1700 fold higher,as compared to the in vivo corrosion rates. This discrepancy is caused by biomolecule adsorption on thesurface, which prevents the transport of water into the magnesium surface on in vivo testing. Among thein vitro experimental conditions, the corrosion rate in SBF solution had the least difference from the invivo implanted specimen.
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