본문 바로가기
KERD
논문KCI 등재

The effect of interleukin-8 in the early stage after anterior cruciate ligament reconstruction with remnant preservation

박홍기|Jae Ang Sim|Beom Koo Lee|Kyung-Ok Kim|Ji-Uk Choi
대한슬관절학회 (Korean Knee Society)|2020.12|Knee Surgery and Related Research|제32권 |pp. 5-5|DOI 10.1186/s43019-019-0024-0

1

조회

0

다운로드

0

인용

0

참고문헌

키워드

Interleukin-8AngiogenesisAnterior cruciate ligament reconstructionRemnant preservationJoint fluid

초록

Purpose: We studied the effect of interleukin-8 (IL-8) as the factor for angiogenesis in the joint fluid of remnantpreserved anterior cruciate ligament reconstruction (RP-ACLR). Materials and methods: We measured 12 cytokines in joint fluid by multiplex assay and assessed the relationship between IL-8 and vascular endothelial growth factor (VEGF) concentrations. The signal intensity and mean sagittal diameter via postoperative magnetic resonance imaging (MRI) scans were evaluated and the stress X-ray image was analyzed at 3, 6, and 12 months after operation. Results: The IL-8 concentration was highest 3 months postoperatively in those patients who underwent RP-ACLR. Clinical data also showed that the signal intensity and stress radiography of the knee graft were significantly better at the early postoperative stage. Discussion: Our results show that IL-8 plays an important role in angiogenesis within 3 months after RP-ACLR. This effect yields better recovery after operation. RP-ACLR patients with high knee stability in clinical data were identical to those with high expression of IL-8 in experimental data. Therefore, IL-8 has been shown to help revascularization and ligamentization of the grafted tendon. These results indicate that IL-8 in RP-ACLR is an important factor for angiogenesis after operation. Unfortunately, the relationship of IL-8 and VEGF in vivo has not been studied. Conclusion: Our results showed that the IL-8 concentration was very high within 3 months after RP-ACLR operation. The increase in concentration of IL-8 over time was consistent with the increase in VEGF concentration. In the IL-8 clinical setting, MRI analysis showed that ACL synovialization and tension were better in patients who underwent the remnant preservation method. In addition, it was shown that RP-ACLR may be advantageous for early anterior stability within 1 year post operation and beneficial for tendon graft in the early stage post operation. Taken together, our findings suggest that IL-8 may contribute to angiogenesis which is helpful for revascularization and ligamentization of the graft tendon in the early stages of RP-ACLR.

Abstract

Purpose: We studied the effect of interleukin-8 (IL-8) as the factor for angiogenesis in the joint fluid of remnantpreserved anterior cruciate ligament reconstruction (RP-ACLR). Materials and methods: We measured 12 cytokines in joint fluid by multiplex assay and assessed the relationship between IL-8 and vascular endothelial growth factor (VEGF) concentrations. The signal intensity and mean sagittal diameter via postoperative magnetic resonance imaging (MRI) scans were evaluated and the stress X-ray image was analyzed at 3, 6, and 12 months after operation. Results: The IL-8 concentration was highest 3 months postoperatively in those patients who underwent RP-ACLR. Clinical data also showed that the signal intensity and stress radiography of the knee graft were significantly better at the early postoperative stage. Discussion: Our results show that IL-8 plays an important role in angiogenesis within 3 months after RP-ACLR. This effect yields better recovery after operation. RP-ACLR patients with high knee stability in clinical data were identical to those with high expression of IL-8 in experimental data. Therefore, IL-8 has been shown to help revascularization and ligamentization of the grafted tendon. These results indicate that IL-8 in RP-ACLR is an important factor for angiogenesis after operation. Unfortunately, the relationship of IL-8 and VEGF in vivo has not been studied. Conclusion: Our results showed that the IL-8 concentration was very high within 3 months after RP-ACLR operation. The increase in concentration of IL-8 over time was consistent with the increase in VEGF concentration. In the IL-8 clinical setting, MRI analysis showed that ACL synovialization and tension were better in patients who underwent the remnant preservation method. In addition, it was shown that RP-ACLR may be advantageous for early anterior stability within 1 year post operation and beneficial for tendon graft in the early stage post operation. Taken together, our findings suggest that IL-8 may contribute to angiogenesis which is helpful for revascularization and ligamentization of the graft tendon in the early stages of RP-ACLR.

참고문헌 (28)

  1. Adams D, "Current concepts for anterior cruciate ligament reconstruction : a criterion–based rehabilitation progression", J Orthop Sports Phys Ther, 42, pp.601~614 (2012)
  2. Lee BI, "Anatomic single-bundle anterior cruciate ligament reconstruction with remnant preservation using outside-in technique", Arthrosc Tech, 4, pp.e331~e334 (2015)
  3. Ochi M, "The regeneration of sensory neurons in the reconstruction of the anterior cruciate ligament", J Bone Joint Surg Br, 81, pp.902~906 (1999)
  4. Schultz RA, "Mechanoreceptors in human cruciate ligaments. A histological study", J Bone Joint Surg Am, 66, pp.1072~1076 (1984)
  5. Georgoulis AD, "The presence of proprioceptive mechanorecptors in the remnants of the ruptured ACL as a possible source of re-innervation of the ACL autograft", Knee Surg Sports Traumatol Arthrosc, 9, pp.364~368 (2001)
  6. 이병일, "슬괵건을 이용한 관절경적 전방십자인대 재건술시 잔유조직 보존정도에 따른 임상결과 비교", 대한정형외과학회지, 40(3), pp.284~292 (2005), 대한정형외과학회
  7. Ochi M, "Anterior cruciate ligament augmentation procedure with a 1-incision technique : anteromedial bundle or posterolateral bundle reconstruction", Arthroscopy, 22, pp.463.e1~463.e5 (2006)
  8. Graham GP, "Early osteoarthritis in young sportmen with severe anterolateral instability of the knee", Injury, 19, pp.247~248 (1988)
  9. Nakahara H, "Anti-interleukin-6 receptor antibody therapy reduced vascular endothelial growth factor production in rheumatoid arthritis", Arthritis Rheum, 48, pp.1521~1529 (2003)
  10. Nishimoto N, "Treatment of rheumatoid arthritis with humanized antiinterleukin-6 receptor antibody : a multicenter, double blind, placebo-controlled trial", Arthritis Rheum, 50, pp.1761~1769 (2004)
  11. Bigoni M, "Role of interleukin-10 in the synovial fluid of the anterior cruciate ligament injured knee", Eur Rev Med Pharmacol Sci, 23(3), pp.932~940 (2019)
  12. Hou Y, "IL-8 enhances the angiogenic potential of human bone marrow mesenchymal stem cells by increasing vascular endothelial growth factor", Cell Biol Int, 38, pp.1050~1059 (2014)
  13. Hu DE, "Interleukin-8 stimulates angiogenesis in rats", Inflammation, 17, pp.135~143 (1993)
  14. Kocher AA, "Myocardial homing and neovascularization by human bone marrow angioblasts is regulated by IL-8", Gro CXC chemokines, 2006, pp.40, 455~464
  15. Li A, "IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis", J Immunol, 170, pp.3369~3376 (2003)
  16. Kim SH, "Changes of synovial fluid cytokine in anterior cruciate ligament injury", J Korean Arthrosc Soc, 11(1), pp.7~12 (2007)
  17. Hong SJ, "Postoperative MR findings of the healthy ACL grafts : correlation with second look arthroscopy", Clin Imaging, 29, pp.55~59 (2005)
  18. Song GY, "Biomechanical and biological findings between acute anterior cruciate ligament reconstruction with and without an augmented remnant repair : a comparative in vivo animal study", Arthroscopy, 32, pp.307~319 (2016)
  19. Ahn JH, "Anterior cruciate ligament reconstruction using remnant preservation and a femoral tensioning technique: clinical and magnetic resonance imaging results", Arthroscopy, 27, pp.1079~1089 (2011)
  20. Gohil S, "Anterior cruciate ligament reconstruction using autologous double hamstrings: a comparison of standard versus minimal debridement techniques using MRI to assess revascularization. A randomized prospective study with a one-year followup", J Bone Joint Surg Br, 89, pp.1165~1171 (2007)
  21. Zhang Q, "The effect of remnant preservation on tibia tunnel enlargement in ACL reconstruction with hamstring autograft : a prospective randomized controlled trial", Knee Surg Sports Traumatol Arthrosc, 22, pp.166~173 (2014)
  22. Sun L, "Comparison of graft healing in anterior cruciate ligament reconstruction with and without a preserved remnant rabbits", Knee, 20, pp.537~544 (2013)
  23. Lee BI, "Arthroscopic anterior cruciate ligament construction with the tibial-remnant preserving technique using a hamstring graft", Arthroscopy, 22, pp.340.e1~347.e7 (2006)
  24. Hong L, "Anterior cruciate ligament reconstruction with remnant preservation : a prospective, randomized controlled study", Am J Sports Med, 40, pp.2747~2755 (2012)
  25. Zhang L, "A comparative animal study of tendon grafts healing after remnant-preserving versus conventional anterior cruciate ligament", Med Sci Monit, 22, pp.3426~3437 (2016)
  26. Szekanecz Z, "Chemokines in rheumatoid arthritis", Springer Semin Immunopathol, 20, pp.115~132 (1998)
  27. Sozzani S, "Dendritic cell–endothelial cell cross talk in angiogenesis", Trends Immunol, 28, pp.385~392 (2007)
  28. Maruotti N, "Angiogenesis in rheumatoid arthritis", Histol Histopathol, 21, pp.557~566 (2006)

관련 논문AI추천

Revascularization to the bone tunnel wall after anterior cruciate ligament reconstruction may relate to the distance from the vesselsArai Yuji, Atsumi Satoru, Hara Kunio, Inoue Hiroaki, Kanamura Hitoshi, Mikami Yasuo, Nakagawa Shuji대한슬관절학회 · Knee Surgery and Related Research2020 · 제32권 Evaluation parameters of graft maturation on second-look arthroscopy following anterior cruciate ligament reconstruction: a systematic reviewJae Hyun Jung, Ji Hoon Bae, Jong-Hyub Song, Sang­Gyun Kim대한슬관절학회 · Knee Surgery and Related Research2019 · 제31권 제1호Influence of posteromedial corner injuries on clinical outcome and second-look arthroscopic findings after allograft transtibial anterior cruciate ligament reconstruction박희곤, Kwon Soon-Min, Yoo Jun-Young대한슬관절학회 · Knee Surgery and Related Research2020 · 제32권 Remnant-Preserving Anterior Cruciate Ligament Reconstruction Using a Three-Dimensional Fluoroscopic Navigation SystemHironari Masuda, Hiroshi Inui, Kensuke Nakamura, Ryota Yamagami, Sakae Tanaka, Shuji Taketomi, Takaki Sanada, Takumi Nakagawa대한슬관절학회 · Knee Surgery and Related Research2014 · 제26권 제3호Outcome Differences of Remnant-Preserving versus Non-Preserving Methods in Arthroscopic Anterior Cruciate Ligament Reconstruction: A Meta-analysis with Subgroup analysis권세원, 김용범, 김준범, 서기원, 원성훈, 최형석, Byung-Il Lee, Jae-Hyung Kim, Kyung-Dae Min, Su Yeon Park대한슬관절학회 · Knee Surgery and Related Research2020 · 제32권 Early Return to Play After Anterior Cruciate Ligament Reconstruction: Is It Worth the Risk?Ferenc Rárosi, Katalin Török, László Török, Péter Jávor, Petra Hartmann대한재활의학회 · Annals of Rehabilitation Medicine2022 · 제46권 제2호

이 간행물의 다른 논문 (63건)

Comparison of the postoperative analgesic effect for infiltration between the popliteal artery and the capsule of the posterior knee and that of periarticular multimodal drug injection in total knee arthroplasty: retrospective study in the immediate postoperative period손원용, Ok-Gul Kim, In Seung Lee, Seung-Suk Seo, Dae-Won Jungpp. 1-1Correlation between meniscal extrusion and symptom duration, alignment, and arthritic changes in medial meniscus posterior root tear: research article김동휘, Hyun Hak Kim, 이광철, Dong Hyuk Chapp. 2-2Outcomes and component-positioning in total knee arthroplasty may be comparable between supervised trained surgeons and their supervisorYoshinari Miyamoto, Yozo Katsuragawa, Kazumi Gotopp. 3-3Calcium phosphate injection of symptomatic bone marrow lesions of the knee: what is the current clinical evidence?J. T. K. Melton, D. S. Angadi, D. Edwardspp. 4-4Biomechanical function of the anterolateral ligament of the knee: a systematic reviewSoo-Young Jeong, Jin Kyu Lee, 양재혁, 서영진pp. 6-6
원문 보기