본문 바로가기
KERD
논문KCI 등재

농업종사자의 직업적 유해인자와 건강 영향: 기전 중심의 고찰

Occupational Hazardous Factors and Health Impacts among Agricultural Workers: a Mechanism-Based Review

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

초록

Objectives: This study aims to systematically review the health impacts and mechanisms of exposure to hazardous factors among agricultural workers to contribute to the development of strategies for health protection and preventive management for agricultural workers. Methods: We analyzed chemical, physical, musculoskeletal, biological, and psychosocial hazards, focusing on their associated health impacts and mechanisms based on previous literature. Results: Chemical hazards, such as pesticides and fertilizers, can cause chronic diseases, poisoning, and respiratory issues. Physical hazards, including noise, vibration, and sunlight exposure, may result in hearing loss, musculoskeletal strain, and skin disorders. Musculoskeletal hazards from repetitive movements and lifting heavy load, and awkward posture can lead to back pain, osteoarthritis, and tendon disorders. Biological hazards, such as bioaerosols and zoonotic pathogens, increase the risk of respiratory diseases and infectious conditions. Psychosocial hazards, including financial stress, social isolation, and extreme weather, contribute to mental health issues like depression, anxiety, and cardiovascular diseases. In agricultural environments with a high proportion of older workers with pre-existing conditions, these risks are further elevated. Conclusions: Understanding the mechanisms of health risks will enhance awareness of the importance of wearing protective equipment and following safety protocols, promoting behavioral changes and improving occupational health in agriculture.

Abstract

Objectives: This study aims to systematically review the health impacts and mechanisms of exposure to hazardous factors among agricultural workers to contribute to the development of strategies for health protection and preventive management for agricultural workers. Methods: We analyzed chemical, physical, musculoskeletal, biological, and psychosocial hazards, focusing on their associated health impacts and mechanisms based on previous literature. Results: Chemical hazards, such as pesticides and fertilizers, can cause chronic diseases, poisoning, and respiratory issues. Physical hazards, including noise, vibration, and sunlight exposure, may result in hearing loss, musculoskeletal strain, and skin disorders. Musculoskeletal hazards from repetitive movements and lifting heavy load, and awkward posture can lead to back pain, osteoarthritis, and tendon disorders. Biological hazards, such as bioaerosols and zoonotic pathogens, increase the risk of respiratory diseases and infectious conditions. Psychosocial hazards, including financial stress, social isolation, and extreme weather, contribute to mental health issues like depression, anxiety, and cardiovascular diseases. In agricultural environments with a high proportion of older workers with pre-existing conditions, these risks are further elevated. Conclusions: Understanding the mechanisms of health risks will enhance awareness of the importance of wearing protective equipment and following safety protocols, promoting behavioral changes and improving occupational health in agriculture.

참고문헌 (102)

  1. Kwon SC, "Work-related hazards among farmers", J Korean Med Assoc, 55(11), pp.1046~1053 (2012)
  2. Lee CG, "Work-related musculoskeletal disorders in Korean farmers", J Korean Med Assoc, 55(11), pp.1054~1062 (2012)
  3. Lee WJ, "Pesticide exposure and health", J Environ Health Sci, 37(2), pp.81~93 (2011)
  4. 송한수, "농업인의 직업성 질병 목록과 가이드", 농촌진흥청, 5~8 (2024)
  5. Fan J, "Pharmacokinetics", Biochem Pharmacol, 87(1), pp.93~120 (2014)
  6. Durrani TS, "Current Occupational & Environmental Medicine", pp.200~203 (2021), McGraw-Hill Education LLC
  7. Baldrick P, "Toxicokinetics in preclinical evaluation", Drug Discov Today, 8(3), pp.127~133 (2003)
  8. 류지영, "직업환경의학", pp.131~138 (2022), 계축문화사
  9. 배상혁, "예방의학과 공중보건학", pp.598~600 (2021), 계축문화사
  10. Testa B, "The influence of lipophilicity on the pharmacokinetic behavior of drugs : Concepts and examples", Perspect Drug Discov Des, 19, pp.179~121 (2000)
  11. Baláž Š, "Lipophilicity in trans-bilayer transport and subcellular pharmacokinetics", Perspect Drug Discov Des, 19, pp.157~177 (2000)
  12. Pelkonen O, "Metabolic activation of toxins : tissue-specific expression and metabolism in target organs", Environ Health Perspect, 105(Suppl 4), pp.767~774 (1997)
  13. Smith MT, "The key characteristics of carcinogens : relationship to the hallmarks of cancer, relevant biomarkers, and assays to measure them", Cancer Epidemiol Biomarkers Prev, 29(10), pp.1887~1190 (2020)
  14. Wang XF, "Inhibitory effects of pesticides on proteasome activity : implication in Parkinson's disease", Neurobiol Dis, 23(1), pp.198~205 (2006)
  15. Costa LG, "Neurotoxicity of pesticides : a brief review", Front Biosci, 13, pp.1240~1249 (2008)
  16. Camilleri A, "The centrality of mitochondria in the pathogenesis and treatment of Parkinson's disease", CNS Neurosci Ther, 20(7), pp.591~602 (2014)
  17. Manasa K, "Phytoconstituents in the Management of Pesticide Induced Parkinson’s Disease–A Review", Biomed Pharmacol J, 12(3), pp.1417~1424 (2019)
  18. Islam MS, "Pesticides and Parkinson’s disease : Current and future perspective", J Chem Neuroanat, 115, pp.101966~ (2021)
  19. Dinis-Oliveira RJ, "Paraquat poisonings : mechanisms of lung toxicity, clinical features, and treatment", Crit Rev Toxicol, 38(1), pp.13~71 (2008)
  20. 손정우, "예방의학과 공중보건학", pp.627~632 (2021), 계축문화사
  21. 김규상, "직업환경의학", pp.77~84 (2022), 계축문화사
  22. Nordmann AS, "Histopathological differences between temporary and permanent threshold shift", Hear Res, 139(1-2), pp.13~30 (2000)
  23. Henderson D, "Impulse noise : critical review", J Acoust Soc Am, 80(2), pp.569~584 (1986)
  24. Yamane H, "Appearance of free radicals in the guinea pig inner ear after noise-induced acoustic trauma", Eur Arch Otorhinolaryngol, 252(8), pp.504~508 (1995)
  25. Fridberger A, "Acoustic overstimulation increases outer hair cell Ca2+ concentrations and causes dynamic contractions of the hearing organ", Proc Natl Acad Sci U S A, 95(12), pp.7127~7132 (1998)
  26. Kim KX, "Vesicular glutamatergic transmission in noise-induced loss and repair of cochlear ribbon synapses", J Neurosci, 39(23), pp.4434~4447 (2019)
  27. Mao H, "Noise-induced hearing loss : updates on molecular targets and potential interventions", Neural Plast, 2021, pp.4784385~ (2021)
  28. Le TN, "Current insights in noise-induced hearing loss : a literature review of the underlying mechanism, pathophysiology, asymmetry, and management options", J Otolaryngol Head Neck Surg, 46(1), pp.41~ (2017)
  29. Lie A, "Occupational noise exposure and hearing : a systematic review", Int Arch Occup Environ Health, 89(3), pp.351~372 (2016)
  30. Basner M, "Auditory and non-auditory effects of noise on health", Lancet, 383(9925), pp.1325~1332 (2014)
  31. Mehrotra A, "A comprehensive review of auditory and non-auditory effects of noise on human health", Noise Health, 26(121), pp.59~69 (2024)
  32. Seward JP, "Current Occupational & Environmental Medicine", pp.193~ (2021), McGraw-Hill Education LLC
  33. 손정우, "예방의학과 공중보건학", pp.633~637 (2021), 계축문화사
  34. 유철인, "직업환경의학", pp.85~93 (2022), 계축문화사
  35. Heaver C, "Hand–arm vibration syndrome : a common occupational hazard in industrialized countries", J Hand Surg Eur Vol, 36(5), pp.354~363 (2011)
  36. Herrick AL, "Pathogenesis of Raynaud's phenomenon", Rheumatology(Oxford), 44(5), pp.587~596 (2005)
  37. Harada N, "Diagnosis of vascular injuries caused by hand-transmitted vibration", Int Arch Occup Environ Health, 81(5), pp.507~518 (2008)
  38. Lander L, "Nerve conduction studies and current perception thresholds in workers assessed for hand –arm vibration syndrome", Occup Med(Lond), 57(4), pp.284~289 (2007)
  39. Charles LE, "Vibration and ergonomic exposures associated with musculoskeletal disorders of the shoulder and neck", Saf Health Work, 9(2), pp.125~132 (2018)
  40. Salminen A, "Photoaging : UV radiation-induced inflammation and immunosuppression accelerate the aging process in the skin", Inflamm Res, 71(7-8), pp.817~831 (2022)
  41. Holick MF, "Biological effects of sunlight, ultraviolet radiation, visible light, infrared radiation and vitamin D for health", Anticancer Res, 36(3), pp.1345~1356 (2016)
  42. Barolet D, "Infrared and skin : Friend or foe", J Photochem Photobiol B, 155, pp.78~85 (2016)
  43. Pourang A, "Effects of visible light on mechanisms of skin photoaging", Photodermatol Photoimmunol Photomed, 38(3), pp.191~196 (2022)
  44. Clydesdale GJ, "Ultraviolet light induced injury : immunological and inflammatory effects", Immunol Cell Biol, 79(6), pp.547~568 (2001)
  45. Ansary TM, "Inflammatory molecules associated with ultraviolet radiation-mediated skin aging", Int J Mol Sci, 22(8), pp.3974~ (2021)
  46. Kripke ML, "Pyrimidine dimers in DNA initiate systemic immunosuppression in UV-irradiated mice", Proc Natl Acad Sci U S A, 89(16), pp.7516~7520 (1992)
  47. Maeda A, "Phenotypic and functional characterization of ultraviolet radiation-induced regulatory T cells", J Immunol, 180(5), pp.3065~3071 (2008)
  48. Shreedhar VK, "Origin and characteristics of ultraviolet-B radiation-induced suppressor T lymphocytes", J Immunol, 161(3), pp.1327~1335 (1998)
  49. Birch-Machin MA, "Mitochondrial DNA damage as a biomarker for ultraviolet radiation exposure and oxidative stress", Br J Dermatol, 169(Suppl 2), pp.9~14 (2013)
  50. Cadet J, "Oxidatively generated damage to cellular DNA by UVB and UVA radiation", Photochem Photobiol, 91(1), pp.140~155 (2015)
  51. Schuch AP, "Sunlight damage to cellular DNA : Focus on oxidatively generated lesions", Free Radic Biol Med, 107, pp.110~124 (2017)
  52. Pálmai-Pallag T, "Inflammationinduced DNA damage and damage-induced inflammation : a vicious cycle", Microbes Infect, 16(10), pp.822~832 (2014)
  53. Boyd DF, "Towards integrating extracellular matrix and immunological pathways", Cytokine, 98, pp.79~86 (2017)
  54. Togashi Y, "Regulatory T cells in cancer immunosuppression-implications for anticancer therapy", Nat Rev Clin Oncol, 16(6), pp.356~371 (2019)
  55. Liu X, "Regulatory B cells induced by ultraviolet B through toll-like receptor 4 signalling contribute to the suppression of contact hypersensitivity responses in mice", Contact Dermatitis, 78(2), pp.117~130 (2018)
  56. Liang H, "Host STING-dependent MDSC mobilization drives extrinsic radiation resistance", Nat Commun, 8(1), pp.1736~ (2017)
  57. Yamazaki S, "Ultraviolet B-induced maturation of CD11b-Type langerin(-)dendritic cells controls the expansion of Foxp3(+)regulatory T cells in the Skin", J Immunol, 200(1), pp.119~129 (2018)
  58. Ciążyńska M, "Ultraviolet radiation and chronic inflammationmolecules and mechanisms involved in skin carcinogenesis: A narrative review", Life(Basel), 11(4), pp.326~ (2021)
  59. Hart PH, "Ultraviolet radiationinduced immunosuppression and its relevance for skin carcinogenesis", Photochem Photobiol Sci, 17(12), pp.1872~1884 (2018)
  60. Morrison SF, "Central mechanisms for thermoregulation", Annu Rev Physiol, 81, pp.285~308 (2019)
  61. Cramer MN, "Human temperature regulation under heat stress in health, disease, and injury", Physiol Rev, 102(4), pp.1907~1989 (2022)
  62. Gauer R, "Heat-related illnesses", Am Fam Physician, 99(8), pp.482~489 (2019)
  63. McMahon JA, "Cold weather issues in sideline and event management", Curr Sports Med Rep, 11(3), pp.135~141 (2012)
  64. 손정우, "예방의학과 공중보건학", pp.652~657 (2021), 계축문화사
  65. 김대환, "직업환경의학", pp.111~117 (2022), 계축문화사
  66. Jurkovich GJ, "Environmental cold-induced injury", Surg Clin North Am, 87(1), pp.247~267 (2007)
  67. Osborne A, "Prevalence of musculoskeletal disorders among farmers : A systematic review", Am J Ind Med, 55(2), pp.143~158 (2012)
  68. Akbar KA, "Work-related musculoskeletal disorders among farmers in the Southeast Asia region : A systematic review", Saf Health Work, 14(3), pp.243~249 (2023)
  69. Gracey E, "Tendon and ligament mechanical loading in the pathogenesis of inflammatory arthritis", Nat Rev Rheumatol, 16(4), pp.193~207 (2020)
  70. Snedeker JG, "Tendon injury and repair-A perspective on the basic mechanisms of tendon disease and future clinical therapy", Acta Biomater, 63, pp.18~36 (2017)
  71. Galloway MT, "The role of mechanical loading in tendon development, maintenance, injury, and repair", J Bone Joint Surg Am, 95(17), pp.1620~1628 (2013)
  72. Lavagnino M, "Tendon mechanobiology : Current knowledge and future research opportunities", J Orthop Res, 33(6), pp.813~822 (2015)
  73. Fredberg U, "Chronic tendinopathy tissue pathology, pain mechanisms, and etiology with a special focus on inflammation", Scand J Med Sci Sports, 18(1), pp.3~15 (2008)
  74. Taechasubamorn P, "Prevalence of low back pain among rice farmers in a rural community in Thailand", J Med Assoc Thai, 94(5), pp.616~621 (2011)
  75. Dutkiewicz J, "Biological agents as occupational hazards-selected issues", Ann Agric Environ Med, 18(2), pp.286~293 (2011)
  76. Mbareche H, "Bioaerosols play a major role in the nasopharyngeal microbiota content in agricultural environment", Int J Environ Res Public Health, 16(8), pp.1375~ (2019)
  77. Wéry N, "Bioaerosols from composting facilities--a review", Front Cell Infect Microbiol, 4, pp.42~ (2014)
  78. Bonifait L, "Workers' exposure to bioaerosols from three different types of composting facilities", J Occup Environ Hyg, 14(10), pp.815~822 (2017)
  79. Dubuis ME, "Bioaerosols concentrations in working areas in biomethanization facilities", J Air Waste Manag Assoc, 67(11), pp.1258~1271 (2017)
  80. Mbareche H, "A next generation sequencing approach with a suitable bioinformatics workflow to study fungal diversity in bioaerosols released from two different types of composting plants", Sci Total Environ, 601-602, pp.1306~1314 (2017)
  81. Douwes J, "Bioaerosol health effects and exposure assessment : progress and prospects", Ann Occup Hyg, 47(3), pp.187~200 (2003)
  82. Smit LAM, "Occupational endotoxin exposure reduces the risk of atopic sensitization but increases the risk of bronchial hyperresponsiveness", Int Arch Allergy Immunol, 152(2), pp.151~158 (2010)
  83. Kong WS, "Time-spatial distribution of scrub typhus and its environmental ecology", J Korean Geograph Soc, 42(6), pp.863~878 (2007)
  84. Lim HS, "Health hazards of farming and fishing in Korea", J Agric Med Community Health, 27(1), pp.197~215 (2002)
  85. Morand S, "The role of agriculture in human infectious disease outbreaks", CABI Rev, 81, pp.12366~ (2022)
  86. Kemeny ME, "The psychobiology of stress", Curr Dir Psychol Sci, 12(4), pp.124~129 (2003)
  87. Thelin A, "Agricultural medicine: rural occupational and environmental health, safety, and prevention", pp.351~377 (2016), John Wiley & Sons Inc
  88. Jackson M, "Stress, shock, and adaptation in the twentieth century", pp.21~41 (2014), University of Rochester Press
  89. Cannon WB, "Bodily changes in pain, hunger, fear, and rage", pp.20~36 (1953), CH Branford
  90. Gunnar M, "The neurobiology of stress and development", Annu Rev Psychol, 58, pp.145~173 (2007)
  91. Dimsdale JE, "Psychological stress and cardiovascular disease", J Am Coll Cardiol, 51(13), pp.1237~1246 (2008)
  92. Huang JL, "Sudden changes in heart rate variability during the 1999 Taiwan earthquake", Am J Cardiol, 87(2), pp.245~248 (2001)
  93. Matsuo T, "Hemostatic activation and cardiac events after the 1995 Hanshin-Awaji earthquake", Int J Hematol, 67(2), pp.123~129 (1998)
  94. Krantz DS, "Effects of mental stress in patients with coronary artery disease : evidence and clinical implications", JAMA, 283(14), pp.1800~1802 (2000)
  95. Orth-Gomér K, "Marital stress worsens prognosis in women with coronary heart disease : The Stockholm Female Coronary Risk Study", JAMA, 284(23), pp.3008~3014 (2000)
  96. Twisk JW, "Changes in daily hassles and life events and the relationship with coronary heart disease risk factors : a 2-year longitudinal study in 27-29-year-old males and females", J Psychosom Res, 46(3), pp.229~240 (1999)
  97. Jain S, "Effects of perceived stress and uplifts on inflammation and coagulability", Psychophysiology, 44(1), pp.154~160 (2007)
  98. Pariante CM, "The HPA axis in major depression : classical theories and new developments", Trends Neurosci, 31(9), pp.464~468 (2008)
  99. Nemeroff CB, "The neurobiology of depression : inroads to treatment and new drug discovery", J Clin Psychiatry, 66(Suppl 7), pp.5~13 (2005)
  100. Kim L, "Stress, sleep physiology, and related insomnia disorders", J Korean Med Assoc, 53(8), pp.707~716 (2010)
  101. Herbert J, "Do corticosteroids damage the brain?", J Neuroendocrinol, 18(6), pp.393~411 (2006)
  102. Al Jowf GI, "To Predict, Prevent, and Manage Post-Traumatic Stress Disorder(PTSD) : A Review of Pathophysiology, Treatment, and Biomarkers", Int J Mol Sci, 24(6), pp.5238~ (2023)

관련 논문AI추천

이 간행물의 다른 논문 (10건)