Impaired Social and Role Function in Ultra-High Risk for Psychosis and First-Episode Schizophrenia: Its Relations with Negative Symptoms
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Objective: Psychosocial dysfunction was a nettlesome problem of schizophrenia even in their prodromal phase as well as in their first-episode. In addition, its relations with psychopathology were not determined. The aim of the present study was to examine whether the social and role function impairment was found in ultra-high risk for psychosis (UHR) individuals as well as first-episode schizophrenia patients and to explore its relations with psychopathology. Methods: Thirty-seven normal controls, 63 UHR participants and 28 young, first-episode schizophrenia patients were recruited. Psychosocial functioning was examined by using Global function: Social and Role scale. Psychopathologies of positive, negative and depressive symptom were also measured. Results: Social and role functioning in UHR were compromised at the equivalent level of those of first-episode schizophrenia patients. Multiple linear regression analysis revealed that social and role dysfunction was associated with negative symptoms in each UHR and first-episode schizophrenia group. Conclusion: These findings suggest that the significant impairment of social and role function may be appeared before the active psychosis onset at the level of extent to those of first-episode schizophrenia patients. The psychosocial intervention strategy especially targeting the negative symptoms should be developed and provided to individuals from their prepsychotic stage of schizophrenia.
Abstract
Objective: Psychosocial dysfunction was a nettlesome problem of schizophrenia even in their prodromal phase as well as in their first-episode. In addition, its relations with psychopathology were not determined. The aim of the present study was to examine whether the social and role function impairment was found in ultra-high risk for psychosis (UHR) individuals as well as first-episode schizophrenia patients and to explore its relations with psychopathology. Methods: Thirty-seven normal controls, 63 UHR participants and 28 young, first-episode schizophrenia patients were recruited. Psychosocial functioning was examined by using Global function: Social and Role scale. Psychopathologies of positive, negative and depressive symptom were also measured. Results: Social and role functioning in UHR were compromised at the equivalent level of those of first-episode schizophrenia patients. Multiple linear regression analysis revealed that social and role dysfunction was associated with negative symptoms in each UHR and first-episode schizophrenia group. Conclusion: These findings suggest that the significant impairment of social and role function may be appeared before the active psychosis onset at the level of extent to those of first-episode schizophrenia patients. The psychosocial intervention strategy especially targeting the negative symptoms should be developed and provided to individuals from their prepsychotic stage of schizophrenia.
참고문헌 (37)
- American Psychiatric Association, "DSM-5: Diagnostic and Statistical Manual of Mental Disorders", American Psychiatric Publishing, ~ (2013)
- Yung AR, "Psychosis prediction : 12-month follow up of a high-risk("prodromal")group", Schizophr Res, 60, pp.21~32 (2003)
- Yung AR, "Risk factors for psychosis in an ultra high-risk group : psychopathology and clinical features", Schizophr Res, 67, pp.131~142 (2004)
- Velthorst E, "Transition to first episode psychosis in ultra high risk populations: does baseline functioning hold the key?", Schizophr Res, 143, pp.132~137 (2013)
- Valmaggia LR, "Negative psychotic symptoms and impaired role functioning predict transition outcomes in the at-risk mental state : a latent class cluster analysis study", Psychol Med, 43, pp.2311~2325 (2013)
- Addington J, "Patterns of premorbid functioning in first-episode psychosis : initial presentation", Schizophr Res, 62, pp.23~30 (2003)
- Rapoport JL, "The neurodevelopmental model of schizophrenia : update 2005", Mol Psychiatry, 10, pp.434~449 (2005)
- Addington J, "Social functioning in individuals at clinical high-risk for psychosis", Schizophr Res, 99, pp.119~124 (2008)
- Cannon TD, "Prediction of psychosis in youth at high clinical risk : a multisite longitudinal study in North America", Arch Gen Psychiatry, 65, pp.28~37 (2008)
- Perlick DA, "Association of symptomatology and cognitive deficits to functional capacity in schizophrenia", Schizophr Res, 99, pp.192~199 (2008)
- Yamauchi K, "Predictors of subjective and objective quality of life in outpatients with schizophrenia", Psychiatry Clin Neurosci, 62, pp.404~411 (2008)
- Woon PS, "Neurocognitive, clinical and functional correlates of subjective quality of life in Asian outpatients with schizophrenia", Prog Neuropsychopharmacol Biol Psychiatry, 34, pp.463~468 (2010)
- Narvaez JM, "Subjective and objective quality of life in schizophrenia", Schizophr Res, 98, pp.201~208 (2008)
- Mohamed S, "Relationship of cognition and psychopathology to functional impairment in schizophrenia", Am J Psychiatry, 165, pp.978~987 (2008)
- Stouten LH, "Psychotic symptoms, cognition and affect as predictors of psychosocial problems and functional change in first-episode psychosis", Schizophr Res, 158, pp.113~119 (2014)
- Strauss GP, "Negative symptoms and depression predict lower psychological well-being in individuals with schizophrenia", Compr Psychiatry, 53, pp.1137~1144 (2012)
- Rabinowitz J, "Negative symptoms have greater impact on functioning than positive symptoms in schizophrenia : analysis of CATIE data", Schizophr Res, 137, pp.147~150 (2012)
- Hunter R, "Negative symptoms and psychosocial functioning in schizophrenia : neglected but important targets for treatment", Eur Psychiatry, 27, pp.432~436 (2012)
- 송윤영, "Associated Factors of Quality of Life in First-Episode Schizophrenia Patients", PSYCHIATRY INVESTIGATION, 8(3), pp.201~206 (2011), 대한신경정신의학회
- Rocca P, "Depressive and negative symptoms in schizophrenia : different effects on clinical features", Compr Psychiatry, 46, pp.304~310 (2005)
- Masillo A, "Interpersonal sensitivity and functioning impairment in youth at ultra-high risk for psychosis", Eur Child Adolesc Psychiatry, 25, pp.7~16 (2016)
- Svirskis T, "Quality of life and functioning ability in subjects vulnerable to psychosis", Compr Psychiatry, 48, pp.155~160 (2007)
- Schlosser DA, "Modeling the role of negative symptoms in determining social functioning in individuals at clinical high risk of psychosis", Schizophr Res, 169, pp.204~208 (2015)
- Kim KR, "The relationship between psychosocial functioning and resilience and negative symptoms in individuals at ultra-high risk for psychosis", Aust N Z J Psychiatry, 47, pp.762~771 (2013)
- Corcoran CM, "The relationship of social function to depressive and negative symptoms in individuals at clinical high risk for psychosis", Psychol Med, 41, pp.251~261 (2011)
- Ruhrmann S, "Reduced subjective quality of life in persons at risk for psychosis", Acta Psychiatr Scand, 117, pp.357~368 (2008)
- Olvet DM, "Self-awareness of functional impairment in individuals at clinical high-risk for psychosis", Early Interv Psychiatry, 9, pp.100~107 (2015)
- First MB, "Structured Clinical Interview for DSM-IV Axis I Disorders: Non-Patients Edition (SCID-I", NP), 2002
- First MB, "Structured Clinical Interview for DSM-IV Axis I Disorders: Patient Edition (SCID-I", P), 2002
- McGlashan TH, "Structured Interview for Prodromal Syndromes (SIPS), Version 4.0", Yale University, ~ (2003)
- Auther AM, "Global Functioning: Social Scale (GF: Social)", Zucker-Hillside Hospital, ~ (2006)
- Niendam TA, "Global Functioning: Role Scale (GF: Role)", University of California, ~ (2006)
- Andreasen NC, "The Scale for the Assessment of Positive Symptoms (SAPS)", University of Iowa, ~ (1983)
- Andreasen NC, "The Scale for the Assessment of Negative Symptoms (SANS)", University of Iowa, ~ (1983)
- Montgomery SA, "A new depression scale designed to be sensitive to change", Br J Psychiatry, 134, pp.382~389 (1979)
- Mattila-Evenden M, "Determinants of self-rating and expert rating concordance in psychiatric out-patients, using the affective subscales of the CPRS", Acta Psychiatr Scand, 94, pp.386~396 (1996)
- Fusar-Poli P, "Comorbid depressive and anxiety disorders in 509 individuals with an at-risk mental state : impact on psychopathology and transition into psychosis", Schizophr Bull, 40, pp.120~131 (2014)