When Thoughts Are in a Race: Area 10 and Bipolar Disorders
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Racing thought, when patients incessantly shift from one word or sentence to another while pending previous ones unfinished, is a symptom of (hypo)mania in bipolar disorders received less attention hitherto. Here, based on few evidence, we aim to unfold our hypothetical viewpoint that the frontopolar cortex that is believed to play a part in multitasking and management of competing goals might be dysfunctional in bipolar patients and may contribute in induction of flight of ideas. We then address new avenues for future research and try to encourage researchers to design more comprehensive studies to either accept or decline this proposed conjecture.
Abstract
Racing thought, when patients incessantly shift from one word or sentence to another while pending previous ones unfinished, is a symptom of (hypo)mania in bipolar disorders received less attention hitherto. Here, based on few evidence, we aim to unfold our hypothetical viewpoint that the frontopolar cortex that is believed to play a part in multitasking and management of competing goals might be dysfunctional in bipolar patients and may contribute in induction of flight of ideas. We then address new avenues for future research and try to encourage researchers to design more comprehensive studies to either accept or decline this proposed conjecture.
참고문헌 (12)
- Vieta E, "Bipolar disorders", Nat Rev Dis Prim, 4, pp.18008~ (2018)
- Malhi GS, "Mixed mood: the not so united states?", Bipolar Disord, 19, pp.242~245 (2017)
- Arjmand S, "A brain on a roller coaster: can the dopamine reward system act as a protagonist to subdue the ups and downs of bipolar disorder?", Neuroscientist, 24, pp.423~439 (2018)
- Ward T, "Encyclopedia of Autism Spectrum Disorders", pp.1299~1300 (2013), Springer
- Oyebode F, "Sims’ Symptoms in the Mind: Textbook of Descriptive Psychopathology", pp.2015, Sauners
- Dreher JC, "Damage to the frontopolar cortex is associated with impaired multitasking", PLoS One, 3, pp.e3227~ (2008)
- Burgess PW, "The gateway hypothesis of rostral prefrontal cortex(area 10)function", Trends Cogn Sci, 11, pp.290~298 (2007)
- Roca M, "The role of Area 10(BA10)in human multitasking and in social cognition : a lesion study", Neuropsychologia, 49, pp.3525~3231 (2011)
- Koechlin E, "Anterior prefrontal function and the limits of human decision-making", Science, 318, pp.594~598 (2007)
- Mansouri FA, "Managing competing goals-a key role for the frontopolar cortex", Nat Rev Neurosci, 18, pp.645~657 (2017)
- Kaladjian A, "Reduced brain activation in euthymic bipolar patients during response inhibition : an event-related fMRI study", Psychiatry Res, 173, pp.45~51 (2009)
- Schneider MR, "The effects of carbamazepine on prefrontal activation in manic youth with bipolar disorder", Psychiatry Res, 223, pp.268~270 (2014)