Microstructural Changes of Anterior Corona Radiata in Bipolar Depression
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ObjectiveaaIn bipolar disorder, dysregulation of mood may result from white matter abnormalities that change fiber tract length and fiber density. There are few studies evaluating the white matter microstructural changes in bipolar I patients (BD) with depressive episodes. The present study aimed to evaluate anterior corona radiata in BD patients with depressive episode using Diffusion Tensor Imaging (DTI). MethodsaaTwenty-one patients with bipolar depression and 19 healthy controls were investigated and groups were matched for age and gender. Diffusion-weighted echoplanar brain images (DW-EPI) were obtained using a 1.5 T MRI scanner. Regions of interest (ROIs) were manually placed on directional maps based on principal anisotropy. Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values of white matter were measured in the anterior corona radiata (ACR) bilaterally by diffusion tensor imaging. ResultsaaThere was not a significant difference between groups of age and gender (p>0.05). Significantly lower FA was observed in bilateral ACR in bipolar patients with depression compared with healthy individuals. And there is significantly higher ADC values in the left frontal corona radiate in bipolar patients. ConclusionaaWhite matter abnormalities can be detected in patients with BD using DTI. The neuropathology of these abnormalities is unclear, but neuronal and axonal loss, myelin abnormalities and reduced white matter fiber density are likely to be relevant.
Abstract
ObjectiveaaIn bipolar disorder, dysregulation of mood may result from white matter abnormalities that change fiber tract length and fiber density. There are few studies evaluating the white matter microstructural changes in bipolar I patients (BD) with depressive episodes. The present study aimed to evaluate anterior corona radiata in BD patients with depressive episode using Diffusion Tensor Imaging (DTI). MethodsaaTwenty-one patients with bipolar depression and 19 healthy controls were investigated and groups were matched for age and gender. Diffusion-weighted echoplanar brain images (DW-EPI) were obtained using a 1.5 T MRI scanner. Regions of interest (ROIs) were manually placed on directional maps based on principal anisotropy. Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values of white matter were measured in the anterior corona radiata (ACR) bilaterally by diffusion tensor imaging. ResultsaaThere was not a significant difference between groups of age and gender (p>0.05). Significantly lower FA was observed in bilateral ACR in bipolar patients with depression compared with healthy individuals. And there is significantly higher ADC values in the left frontal corona radiate in bipolar patients. ConclusionaaWhite matter abnormalities can be detected in patients with BD using DTI. The neuropathology of these abnormalities is unclear, but neuronal and axonal loss, myelin abnormalities and reduced white matter fiber density are likely to be relevant.
참고문헌 (38)
- Berk M, "Early intervention in bipolar disorders: clinical, biochemical and neuroimaging imperatives", J Affect Disord, 114, pp.1~13 (2009)
- Houenou J, "Neuroimaging-based markers of bipolar disorder: evidence from two meta-analyses", J Affect Disord, 132, pp.344~355 (2011)
- Chaddock CA, "White matter microstructural impairments and genetic liability to familial bipolar I disorder", Br J Psychiatry, 194, pp.527~534 (2009)
- Torgerson CM, "DTI tractography and white matter fiber tract characteristics in euthymic bipolar I patients and healthy control subjects", Brain Imaging Behav, 7, pp.129~139 (2013)
- Benedetti F, "Tract-specific white matter structural disruption in patients with bipolar disorder", Bipolar Disord, 13, pp.414~424 (2011)
- Bruno S, "White matter abnormalities in bipolar disorder: a voxel-based diffusion tensor imaging study", Bipolar Disord, 10, pp.460~468 (2008)
- Smith SM, "Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data", Neuroimage, 31, pp.1487~1505 (2006)
- Filippi M, "Diffusion tensor magnetic resonance imaging in multiple sclerosis", Neurology, 56, pp.304~311 (2001)
- Le Bihan D, "MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders", Radiology, 161, pp.401~407 (1986)
- Adler CM, "Evidence of white matter pathology in bipolar disorder adolescents experiencing their first episode of mania: a diffusion tensor imaging study", Am J Psychiatry, 163, pp.322~324 (2006)
- Beyer JL, "Cortical white matter microstructural abnormalities in bipolar disorder", Neuropsychopharmacology, 12, pp.2225~2229 (2005)
- Regenold WT, "Diffusion-weighted magnetic resonance imaging of white matter in bipolar disorder: a pilot study", Bipolar Disord, 8, pp.188~195 (2006)
- Davis KA, "Decreased cortical gray and cerebral white matter in male patients with familial bipolar I disorder", J Affect Disord, 82, pp.475~485 (2004)
- Brambilla P, "Myelination in bipolar patients and the effects of mood stabilizers on brain anatomy", Curr Pharm Des, 15, pp.2632~2636 (2009)
- Benedetti F, "Disruption of white matter integrity in bipolar depression as a possible structural marker of illness", Biol Psychiatry, 69, pp.309~317 (2011)
- Zanetti MV, "State-dependent microstructural white matter changes in bipolar I depression", Eur Arch Psychiatry Clin Neurosci, 259, pp.316~328 (2009)
- Catani M, "Virtual in vivo interactive dissection of white matter fasciculi in the human brain", Neuroimage, 17, pp.77~94 (2002)
- Wakana S, "Fiber tractbased atlas of human white matter anatomy", Radiology, 230, pp.77~87 (2004)
- Sanjuan PM, "Reduced white matter integrity in the cingulum and anterior corona radiata in posttraumatic stress disorder in male combat veterans: a diffusion tensor imaging study", Psychiatry Res, 214, pp.260~268 (2013)
- Karadag F, "Validity and reliability of young mania rating scale in Turkey", Turk Psychiatry J, 13, pp.107~114 (2002)
- Akdemir A, "Validity, reliability and clinical use of Hamilton Depression Rating Scale", 3P J, 4, pp.251~259 (1996)
- McIntyre RS, "Measurable outcomes in psychiatric disorders: remission as a marker of wellness", Clin Ther, 28, pp.1882~1891 (2006)
- Le Bihan D, "Looking into the functional architecture of the brain with diffusion MRI", Nat Rev Neurosci, 4, pp.469~480 (2003)
- Benedetti F, "Disruption of white matter integrity in bipolar depression as a possible structural marker of illness", Biol Psychiatry, 69, pp.309~317 (2011)
- Skudlarski P, "Diffusion tensor imaging white matter endophenotypes in patients with schizophrenia or psychotic bipolar disorder and their relatives", Am J Psychiatry, 170, pp.886~898 (2013)
- Tkachev D, "Oligodendrocyte dysfunction in schizophrenia and bipolar disorder", Lancet, 362, pp.798~805 (2003)
- Sanjuan PM, "Reduced white matter integrity in the cingulum and anterior corona radiata in posttraumatic stress disorder in male combat veterans: a diffusion tensor imaging study", Psychiatry Res, 214, pp.260~268 (2013)
- Pavuluri MN, "Diffusion tensor imaging study of white matter fiber tracts in pediatric bipolar disorder and attention-deficit", hyperactivity disorder, 2009, pp.7, 586~593
- Niogi SN, "Structural dissociation of attentional control and memory in adults with and without mild traumatic brain injury", Brain, 131, pp.3209~3221 (2008)
- Yin X, "Inferior frontal white matter asymmetry correlates with executive control of attention", Hum Brain Mapp, 34, pp.796~813 (2013)
- Kier EL, "MR imaging of the temporal stem: anatomic dissection tractography of the uncinate fasciculus, inferior occipitofrontal fasciculus, and Meyer’s loop of the optic radiation", AJNR Am J Neuroradiol, 5, pp.677~691 (2004)
- Houenou J, "Increased white matter connectivity in euthymic bipolar patients: diffusion tensor tractography between the subgenual cingulate and the amygdalo-hippocampal complex", Mol Psychiatry, 11, pp.1001~1010 (2007)
- Yurgelun-Todd DA, "White matter abnormalities observed in bipolar disorder: a diffusion tensor imaging study", Bipolar Disord, 9, pp.504~512 (2007)
- Wang F, "Abnormal corpus callosum integrity in bipolar disorder: a diffusion tensor imaging study", Biol Psychiatry, 64, pp.730~733 (2008)
- Versace A, "Right orbitofrontal corticolimbic and left corticocortical white matter connectivity differentiate bipolar and unipolar depression", Biol Psychiatry, 68, pp.560~567 (2010)
- Haznedar MM, "Fronto-thalamo-striatal gray and white matter volumes and anisotropy of their connections in bipolar spectrum illnesses", Biol Psychiatry, 57, pp.733~742 (2005)
- Adler CM, "Voxel-based study of structural changes in first-episode patients with bipolar disorder", Biol Psychiatry, 61, pp.776~781 (2007)
- Strakowski SM, "Brain magnetic resonance imaging of structural abnormalities in bipolar disorder", Arch Gen Psychiatry, 56, pp.254~260 (1999)