Visual Hallucinations and Amyloid Deposition in Parkinson’s Disease Dementia: A Case Report
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Parkinson’s disease dementia (PDD) is notorious for its debilitating clinical course and high mortality rates. Consequently, various attempts to investigate predictors of cognitive decline in Parkinson’s disease (PD) have been made. Here we report a case of a 75-year-old female patient with PD who visited the clinic with complaints of recurrent visual hallucinations and cognitive decline, whose symptoms were ameliorated by the titration of rivastigmine. Imaging results showed pronounced diffuse cortical amyloid deposition evidenced by 18F-florbetaben amyloid positron emission tomography (PET) imaging. This observation suggests that pronounced amyloid deposition and visual hallucinations in PD patients could be clinically significant predictors of cognitive decline in PD patients. Future research should concentrate on accumulating more evidence for possible predictors of cognitive decline and their association with PD pathology that can enable an early intervention and standardized treatment in PDD patients.
Abstract
Parkinson’s disease dementia (PDD) is notorious for its debilitating clinical course and high mortality rates. Consequently, various attempts to investigate predictors of cognitive decline in Parkinson’s disease (PD) have been made. Here we report a case of a 75-year-old female patient with PD who visited the clinic with complaints of recurrent visual hallucinations and cognitive decline, whose symptoms were ameliorated by the titration of rivastigmine. Imaging results showed pronounced diffuse cortical amyloid deposition evidenced by 18F-florbetaben amyloid positron emission tomography (PET) imaging. This observation suggests that pronounced amyloid deposition and visual hallucinations in PD patients could be clinically significant predictors of cognitive decline in PD patients. Future research should concentrate on accumulating more evidence for possible predictors of cognitive decline and their association with PD pathology that can enable an early intervention and standardized treatment in PDD patients.
참고문헌 (46)
- Aarsland D, "A systematic review of prevalence studies of dementia in Parkinson’s disease", Mov Disord, 20, pp.1255~1263 (2005)
- Buter T, "Dementia and survival in Parkinson disease : a 12-year population study", Neurology, 70, pp.1017~1022 (2008)
- Aarsland D, "Prevalence and characteristics of dementia in Parkinson disease : an 8-year prospective study", Arch Neurol, 60, pp.387~392 (2003)
- Williams-Gray CH, "The distinct cognitive syndromes of Parkinson’s disease : 5year follow-up of the CamPaIGN cohort", Brain, 132, pp.2958~2969 (2009)
- Fitts W, "Caregiver report of apathy predicts dementia in Parkinson’s disease", Parkinsonism Relat Disord, 21, pp.992~995 (2015)
- Weintraub D, "Alzheimer’s disease pattern of brain atrophy predicts cognitive decline in Parkinson’s disease", Brain, 135, pp.170~180 (2012)
- Compta Y, "Lewy-and Alzheimer-type pathologies in Parkinson’s disease dementia: which is more important?", Brain, 134, pp.1493~1505 (2011)
- de Lau LM, "Prognosis of parkinson disease : risk of dementia and mortality : the Rotterdam study", Arch Neurol, 62, pp.1265~1269 (2005)
- Hughes CP, "A new clinical scale for the staging of dementia", Br J Psychiatry, 140, pp.566~572 (1982)
- O’Bryant SE, "Staging dementia using clinical dementia rating scale sum of boxes scores : a Texas Alzheimer’s research consortium study", Arch Neurol, 65, pp.1091~1095 (2008)
- Cummings JL, "The neuropsychiatric inventory : comprehensive assessment of psychopathology in dementia", Neurology, 44, pp.2308~2314 (1994)
- 구형모, "일상활동평가-복합(Seoul-Instrumental Activities of Daily Living ; S-IADL)의 신뢰도 및 타당도 연구", 신경정신의학, 43(2), pp.189~199 (2004), 대한신경정신의학회
- Lee DY, "A normative study of the CERAD neuropsychological assessment battery in the Korean elderly", J Int Neuropsychol Soc, 10, pp.72~81 (2004)
- Lee JH, "Korean version of the consortium to establish a registry for Alzheimer’s disease assessment packet(CERAD-K) : Clinical and neuropsychological assessment batteries", Neurobiol Aging, 21, pp.32~ (2000)
- Scheltens P, "Atrophy of medial temporal lobes on MRI in"probable"Alzheimer’s disease and normal ageing : diagnostic value and neuropsychological correlates", J Neurol Neurosurg Psychiatry, 55, pp.967~972 (1992)
- Wahlund L, "A new rating scale for age-related white matter changes applicable to MRI and CT", Stroke, 32, pp.1318~1322 (2001)
- Scheltens P, "Qualitative assessment of cerebral atrophy on MRI : inter-and intra-observer reproducibility in dementia and normal aging", Eur Neurol, 37, pp.95~99 (1997)
- McKhann G, "Clinical diagnosis of Alzheimer’s disease : report of the NINCDSADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease", Neurology, 34, pp.939~944 (1984)
- Johnson KA, "Appropriate use criteria for amyloid PET: a report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer’s Association", J Nucl Med, 54, pp.476~490 (2013)
- Sabri O, "Beta-amyloid imaging with florbetaben", Clin Transl Imaging, 3, pp.13~26 (2015)
- Winslow AR, "Convergence of pathology in dementia with Lewy bodies and Alzheimer’s disease : a role for the novel interaction of alpha-synuclein and presenilin 1 in disease", Brain, 137, pp.1958~1970 (2014)
- Xie A, "Shared mechanisms of neurodegeneration in Alzheimer’s disease and Parkinson’s disease", Biomed Res Int, 2014, pp.648740~ (2014)
- Metzler-Baddeley C, "A review of cognitive impairments in dementia with Lewy bodies relative to Alzheimer’s disease and Parkinson’s disease with dementia", Cortex, 43, pp.583~600 (2007)
- PIB positron emission tomography, "J Neurol Neurosurg Psychiatry", 2008, 1331~1338
- Gomperts SN, "Amyloid is linked to cognitive decline in patients with Parkinson disease without dementia", Neurology, 80, pp.85~91 (2013)
- Svenningsson P, "Cognitive impairment in patients with Parkinson’s disease: diagnosis, biomarkers, and treatment", Lancet Neurol, 11, pp.697~707 (2012)
- Compta Y, "The significance of α-synuclein, amyloid-β and tau pathologies in Parkinson’s disease progression and related dementia", Neurodegener Dis, 13, pp.154~156 (2014)
- Aarsland D, "The rate of cognitive decline in Parkinson disease", Arch Neurol, 61, pp.1906~1911 (2004)
- Fénelon G, "Hallucinations in Parkinson’s disease. Prevalence, phenomenology, and risk factors", Brain, 123, pp.733~745 (2000)
- Factor SA, "Cognitive correlates of hallucinations and delusions in Parkinson’s disease", J Neurol Sci, 347, pp.316~321 (2014)
- Shine JM, "The role of dysfunctional attentional control networks in visual misperceptions in Parkinson’s disease", Human Brain Mapp, 35, pp.2206~2219 (2014)
- Barnes J, "Reality monitoring and visual hallucinations in Parkinson’s disease", Neuropsychologia, 41, pp.565~574 (2003)
- Muller AJ, "Visual hallucinations in Parkinson’s disease : theoretical models", Mov Disord, 29, pp.1591~1598 (2014)
- Ondo WG, "Double-blind, placebo-controlled, unforced titration parallel trial of quetiapine for dopaminergic-induced hallucinations in Parkinson’s disease", Mov Disord, 20, pp.958~963 (2005)
- Rabey JM, "Effect of quetiapine in psychotic Parkinson’s disease patients : a double-blind labeled study of 3 months’ duration", Mov Disord, 22, pp.313~318 (2007)
- Morgante L, "Quetiapine and clozapine in parkinsonian patients with dopaminergic psychosis", Clin Neuropharmacol, 27, pp.153~156 (2004)
- Broadstock M, "Novel pharmaceuticals in the treatment of psychosis in Parkinson’s disease", Expert Rev Clin Pharmacol, 7, pp.779~786 (2014)
- Nagata T, "A case in which mirtazapine reduced auditory hallucinations in a patient with Parkinson disease", Int Psychogeriatr, 25, pp.1199~1201 (2013)
- Tagai K, "Mirtazapine improves visual hallucinations in Parkinson’s disease : a case report", Psychogeriatrics, 13, pp.103~107 (2013)
- Nishioka K, "Quantitative evaluation of electroconvulsive therapy for Parkinson’s disease with refractory psychiatric symptoms", J Neural Transm, 121, pp.1405~1410 (2014)
- Boroojerdi B, "Reduction of human visual cortex excitability using 1-Hz transcranial magnetic stimulation", Neurology, 54, pp.1529~1531 (2000)
- Merabet LB, "Suppression of complex visual hallucinatory experiences by occipital transcranial magnetic stimulation : a case report", Neurocase, 9, pp.436~440 (2003)
- Burn D, "Effects of rivastigmine in patients with and without visual hallucinations in dementia associated with Parkinson’s disease", Mov Disord, 21, pp.1899~1907 (2006)
- Bullock R, "Rivastigmine for the treatment of dementia and visual hallucinations associated with Parkinson’s disease : a case series", Curr Med Res Opin, 18, pp.258~264 (2002)
- Cummings JL, "Cholinesterase inhibitors : a new class of psychotropic compounds", Am J Psychiatry, 157, pp.4~15 (2000)
- Blom JD, "Musical hallucinations treated with acetylcholinesterase inhibitors", Front Psychiatry, 6, pp.46~ (2015)
