Risk of Cognitive Impairment in Patients With Parkinson’s Disease With Visual Hallucinations and Subjective Cognitive Complaints
1
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Background and Purpose Visual hallucinations (VH) and subjective cognitive complaints (SCC) are associated with cognitive impairment (CI) in Parkinson’s disease. Our aims were to determine the association between VH and SCC and the risk of CI development in a cohort of patients with Parkinson’s disease and normal cognition (PD-NC). Methods Patients with PD-NC (total score of >80 on the Parkinson’s Disease Cognitive Rating Scale [PD-CRS]) recruited from the Spanish COPPADIS cohort from January 2016 to November 2017 were followed up after 2 years. Subjects with a score of ≥1 on domain 5 and item 13 of the Non-Motor Symptoms Scale at baseline (V0) were considered as “with SCC” and “with VH,” respectively. CI at the 2-year follow-up (plus or minus 1 month) (V2) was defined as a PD-CRS total score of <81. Results At V0 (n=376, 58.2% males, age 61.14±8.73 years [mean±SD]), the frequencies of VH and SCC were 13.6% and 62.2%, respectively. VH were more frequent in patients with SCC than in those without: 18.8% (44/234) vs 4.9% (7/142), p<0.0001. At V2, 15.2% (57/376) of the patients had developed CI. VH presenting at V0 was associated with a higher risk of CI at V2 (odds ratio [OR]=2.68, 95% confidence interval=1.05–6.83, p=0.039) after controlling for the effects of age, disease duration, education, medication, motor and nonmotor status, mood, and PD-CRS total score at V0. Although SCC were not associated with CI at V2, presenting both VH and SCC at V0 increased the probability of having CI at V2 (OR=3.71, 95% confidence interval= 1.36–10.17, p=0.011). Conclusions VH were associated with the development of SCC and CI at the 2-year follow-up in patients with PD-NC.
Abstract
Background and Purpose Visual hallucinations (VH) and subjective cognitive complaints (SCC) are associated with cognitive impairment (CI) in Parkinson’s disease. Our aims were to determine the association between VH and SCC and the risk of CI development in a cohort of patients with Parkinson’s disease and normal cognition (PD-NC). Methods Patients with PD-NC (total score of >80 on the Parkinson’s Disease Cognitive Rating Scale [PD-CRS]) recruited from the Spanish COPPADIS cohort from January 2016 to November 2017 were followed up after 2 years. Subjects with a score of ≥1 on domain 5 and item 13 of the Non-Motor Symptoms Scale at baseline (V0) were considered as “with SCC” and “with VH,” respectively. CI at the 2-year follow-up (plus or minus 1 month) (V2) was defined as a PD-CRS total score of <81. Results At V0 (n=376, 58.2% males, age 61.14±8.73 years [mean±SD]), the frequencies of VH and SCC were 13.6% and 62.2%, respectively. VH were more frequent in patients with SCC than in those without: 18.8% (44/234) vs 4.9% (7/142), p<0.0001. At V2, 15.2% (57/376) of the patients had developed CI. VH presenting at V0 was associated with a higher risk of CI at V2 (odds ratio [OR]=2.68, 95% confidence interval=1.05–6.83, p=0.039) after controlling for the effects of age, disease duration, education, medication, motor and nonmotor status, mood, and PD-CRS total score at V0. Although SCC were not associated with CI at V2, presenting both VH and SCC at V0 increased the probability of having CI at V2 (OR=3.71, 95% confidence interval= 1.36–10.17, p=0.011). Conclusions VH were associated with the development of SCC and CI at the 2-year follow-up in patients with PD-NC.
참고문헌 (49)
- Pagonabarraga J, "Cognitive impairment and dementia in Parkinson's disease", Neurobiol Dis, 46, pp.590~596 (2012)
- Aarsland D, "Cognitive decline in Parkinson disease", Nat Rev Neurol, 13, pp.217~231 (2017)
- Pigott K, "Longitudinal study of normal cognition in Parkinson disease", Neurology, 85, pp.1276~1282 (2015)
- Pedersen KF, "Natural course of mild cognitive impairment in Parkinson disease : a 5-year population-based study", Neurology, 88, pp.767~774 (2017)
- Aarsland D, "Parkinson disease-associated cognitive impairment", Nat Rev Dis Primers, 7, pp.47~ (2021)
- Aarsland D, "The epidemiology of dementia associated with Parkinson disease", J Neurol Sci, 289, pp.18~22 (2010)
- Murphy N, "Exploring bottom-up visual processing and visual hallucinations in Parkinson’s disease with dementia", Front Neurol, 11, pp.579113~ (2021)
- Aarsland D, "Prevalence and characteristics of dementia in Parkinson disease : an 8-year prospective study", Arch Neurol, 60, pp.387~392 (2003)
- Goetz CG, "Mortality and hallucinations in nursing home patients with advanced Parkinson’s disease", Neurology, 45, pp.669~671 (1995)
- Erro R, "Do subjective memory complaints herald the onset of mild cognitive impairment in Parkinson disease?", J Geriatr Psychiatry Neurol, 27, pp.276~281 (2014)
- Hong JY, "Subjective cognitive decline predicts future deterioration in cognitively normal patients with Parkinson’s disease", Neurobiol Aging, 35, pp.1739~1743 (2014)
- Barbosa RP, "Cognitive complaints in Parkinson’s disease patients: from subjective cognitive complaints to dementia and affective disorders", J Neural Transm(Vienna), 126, pp.1329~1335 (2019)
- Baschi R, "Frequency and correlates of subjective memory complaints in Parkinson’s disease with and without mild cognitive impairment : data from the Parkinson’s disease cognitive impairment study", J Alzheimers Dis, 63, pp.1015~1024 (2018)
- Purri R, "Subjective cognitive complaint in Parkinson’s disease patients with normal cognition : canary in the coal mine?", Mov Disord, 35, pp.1618~1625 (2020)
- Chua CY, "Subjective cognitive complaints in early Parkinson’s disease patients with normal cognition are associated with affective symptoms", Parkinsonism Relat Disord, 82, pp.24~28 (2021)
- Pan C, "Subjective cognitive complaints in newly-diagnosed Parkinson’s disease with and without mild cognitive impairment", Front Neurosci, 15, pp.761817~ (2021)
- Lehrner J, "Subjective memory complaints, depressive symptoms and cognition in Parkinson’s disease patients", Eur J Neurol, 21, pp.1276~1284 (2014)
- Santos García D, "COPPADIS-2015(COhort of Patients with PArkinson’s DIsease in Spain, 2015) : an ongoing global Parkinson’s disease project about disease progression with more than 1000 subjects included. Results from the baseline evaluation", Eur J Neurol, 26, pp.1399~1407 (2019)
- Santos-García D, "COPPADIS-2015(COhort of Patients with PArkinson’s DIsease in Spain, 2015), a global--clinical evaluations, serum biomarkers, genetic studies and neuroimaging--prospective, multicenter, non-interventional, long-term study on Parkinson’s disease progression", BMC Neurol, 16, pp.26~ (2016)
- Hughes AJ, "Accuracy of clinical diagnosis of idiopathic Parkinson’s disease : a clinico-pathological study of 100cases", J Neurol Neurosurg Psychiatry, 55, pp.181~184 (1992)
- Dubois B, "Diagnostic procedures for Parkinson’s disease dementia : recommendations from the movement disorder society task force", Mov Disord, 22, pp.2314~2324 (2007)
- Pagonabarraga J, "Parkinson’s disease-cognitive rating scale : a new cognitive scale specific for Parkinson’s disease", Mov Disord, 23, pp.998~1005 (2008)
- Fernández de Bobadilla R, "Parkinson’s disease-cognitive rating scale : psychometrics for mild cognitive impairment", Mov Disord, 28, pp.1376~1383 (2013)
- Chaudhuri KR, "The metric properties of a novel non-motor symptoms scale for Parkinson’s disease : results from an international pilot study", Mov Disord, 22, pp.1901~1911 (2007)
- Schade S, "Levodopa equivalent dose conversion factors : an updated proposal including opicapone and safinamide", Mov Disord Clin Pract, 7, pp.343~345 (2020)
- Schad DJ, "How to capitalize on a priori contrasts in linear(mixed)models : a tutorial", J Mem Lang, 110, pp.104038~ (2020)
- Barnes J, "Visual hallucinations in Parkinson’s disease : a review and phenomenological survey", J Neurol Neurosurg Psychiatry, 70, pp.727~733 (2001)
- Williams DR, "Visual hallucinations in the diagnosis of idiopathic Parkinson’s disease : a retrospective autopsy study", Lancet Neurol, 4, pp.605~610 (2005)
- Gibson G, "Frequency, prevalence, incidence and risk factors associated with visual hallucinations in a sample of patients with Parkinson’s disease : a longitudinal 4-year study", Int J Geriatr Psychiatry, 28, pp.626~631 (2013)
- Lenka A, "Minor hallucinations in Parkinson disease : a subtle symptom with major clinical implications", Neurology, 93, pp.259~266 (2019)
- Clegg BJ, "Categorising visual hallucinations in early Parkinson’s disease", J Parkinsons Dis, 8, pp.447~453 (2018)
- Bejr-Kasem H, "Minor hallucinations reflect early gray matter loss and predict subjective cognitive decline in Parkinson’s disease", Eur J Neurol, 28, pp.438~447 (2021)
- Santos García D, "Constipation predicts cognitive decline in Parkinson’s disease : results from the COPPADIS cohort at 2-year follow-up and comparison with a control group", J Parkinsons Dis, 12, pp.315~331 (2022)
- Santos-García D, "The impact of freezing of gait on functional dependency in Parkinson’s disease with regard to motor phenotype", Neurol Sci, 41, pp.2883~2892 (2020)
- Santos-García D, "Non-motor symptom burden is strongly correlated to motor complications in patients with Parkinson’s disease", Eur J Neurol, 27, pp.1210~1223 (2020)
- Santos García D, "Falls predict acute hospitalization in Parkinson’s disease", J Parkinsons Dis (2021)[DOI]
- Wood RA, "Fifty percent prevalence of extracampine hallucinations in Parkinson’s disease patients", Front Neurol, 6, pp.263~ (2015)
- Martinez-Martin P, "The impact of non-motor symptoms on health-related quality of life of patients with Parkinson’s disease", Mov Disord, 26, pp.399~406 (2011)
- Sanchez-Ramos JR, "Visual hallucinations associated with Parkinson disease", Arch Neurol, 53, pp.1265~1268 (1996)
- Zhu J, "Prevalence and risk factors for visual hallucinations in Chinese patients with Parkinson’s disease", J Neurol Sci, 372, pp.471~476 (2017)
- Omoto S, "Risk factors for minor hallucinations in Parkinson’s disease", Acta Neurol Scand, 143, pp.538~544 (2021)
- Williams-Gray CH, "The distinct cognitive syndromes of Parkinson’s disease : 5year follow-up of the CamPaIGN cohort", Brain, 132(Pt 11), pp.2958~2969 (2009)
- Compta Y, "Combined dementia-risk biomarkers in Parkinson’s disease : a prospective longitudinal study", Parkinsonism Relat Disord, 19, pp.717~724 (2013)
- Visser F, "Visual hallucinations in Parkinson’s disease are associated with thinning of the inner retina", Sci Rep, 10, pp.21110~ (2020)
- Li T, "Increased substantia nigra echogenicity correlated with visual hallucinations in Parkinson’s disease : a Chinese population-based study", Neurol Sci, 41, pp.661~667 (2020)
- Jessen F, "The characterisation of subjective cognitive decline", Lancet Neurol, 19, pp.271~278 (2020)
- Galtier I, "Subjective cognitive decline and progression to dementia in Parkinson’s disease : a long-term follow-up study", J Neurol, 266, pp.745~754 (2019)
- Mosimann UP, "A semi-structured interview to assess visual hallucinations in older people", Int J Geriatr Psychiatry, 23, pp.712~718 (2008)
- Thomas-Antérion C, "The cognitive complaint interview(CCI)", Psychogeriatrics, 6(S1), pp.S18~S22 (2006)