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No Association between the Polymorphism rs6943555 in the AUTS2 Gene and Personality Traits in Japanese University Students

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키워드

주제분류정신과학

초록

Objective: The autism susceptibility candidate 2 (AUTS2) gene has been implicated in multiple neurological disorders. Several recent studies have revealed that the polymorphism rs6943555 in the AUTS2 gene is broadly associated with human mental function and behavior. Therefore, in the present study we investigated whether the polymorphism rs6943555 is associated with human personality traits in Japanese university students. In addition, our previous study reported that the AUTS2 rs6943555-rs9886351 haplotype is associated with alcohol dependence. As a preliminary analysis, we also examined whether the AUTS2 haplotypes are related to personality traits. Methods: After written informed consent had been obtained from the participants, two AUTS2 polymorphisms were analyzed, and personality was assessed using the Temperament and Character Inventory (TCI) in 190 university students. In addition, in order to exclude the influence of the results for students with mental health problems, we gave the Patient Health Questionnaire-9 (PHQ-9) to all subjects. Results: In all the subjects, there was a main effect of the polymorphism rs6943555 genotype on reward dependence (p=0.038) and cooperativeness (p=0.031), although the significance was lost on Bonferroni correction. Similarly, on analysis that excluded the subjects with PHQ-9 scores≥10, no significant association with any TCI dimension score among the rs6943555 genotypes was seen. There was no effect of the rs6943555-rs9886351 haplotypes on the TCI dimension scores. Conclusion: This study suggests that the polymorphism AUTS2 rs6943555 is not associated with personality traits. Further large-scale studies with more subjects using other self-report questionnaires are needed.

Abstract

Objective: The autism susceptibility candidate 2 (AUTS2) gene has been implicated in multiple neurological disorders. Several recent studies have revealed that the polymorphism rs6943555 in the AUTS2 gene is broadly associated with human mental function and behavior. Therefore, in the present study we investigated whether the polymorphism rs6943555 is associated with human personality traits in Japanese university students. In addition, our previous study reported that the AUTS2 rs6943555-rs9886351 haplotype is associated with alcohol dependence. As a preliminary analysis, we also examined whether the AUTS2 haplotypes are related to personality traits. Methods: After written informed consent had been obtained from the participants, two AUTS2 polymorphisms were analyzed, and personality was assessed using the Temperament and Character Inventory (TCI) in 190 university students. In addition, in order to exclude the influence of the results for students with mental health problems, we gave the Patient Health Questionnaire-9 (PHQ-9) to all subjects. Results: In all the subjects, there was a main effect of the polymorphism rs6943555 genotype on reward dependence (p=0.038) and cooperativeness (p=0.031), although the significance was lost on Bonferroni correction. Similarly, on analysis that excluded the subjects with PHQ-9 scores≥10, no significant association with any TCI dimension score among the rs6943555 genotypes was seen. There was no effect of the rs6943555-rs9886351 haplotypes on the TCI dimension scores. Conclusion: This study suggests that the polymorphism AUTS2 rs6943555 is not associated with personality traits. Further large-scale studies with more subjects using other self-report questionnaires are needed.

참고문헌 (35)

  1. Ebstein RP, "Personality and polymorphisms of genes involved in aminergic neurotransmission", Eur J Pharmacol, 410, pp.205~214 (2000)
  2. Kusumi I, "Relationship between XBP1 genotype and personality traits assessed by TCI and NEO-FFI", Neurosci Lett, 391, pp.7~10 (2005)
  3. Bouchard TJ Jr., "Genes, environment, and personality", Science, 264, pp.1700~1701 (1994)
  4. Huang XL, "A de novo balanced translocation breakpoint truncating the autism susceptibility candidate 2 (AUTS2) gene in a patient with autism", Am J Med Genet A, 152A, pp.2112~2114 (2010)
  5. Ben-David E, "Identification of a functional rare variant in autism using genome-wide screen for monoallelic expression", Hum Mol Genet, 20, pp.3632~3641 (2011)
  6. Elia J, "Rare structural variants found in attention-deficit hyperactivity disorder are preferentially associated with neurodevelopmental genes", Mol Psychiatry, 15, pp.637~646 (2010)
  7. McCarthy SE, "De novo mutations in schizophrenia implicate chromatin remodeling and support a genetic overlap with autism and intellectual disability", Mol Psychiatry, 19, pp.652~658 (2014)
  8. Hattori E, "Preliminary genome-wide association study of bipolar disorder in the Japanese population", Am J Med Genet B Neuropsychiatr Genet, 150B, pp.1110~1117 (2009)
  9. Hori K, "Cytoskeletal regulation by AUTS2 in neuronal migration and neuritogenesis", Cell Rep, 9, pp.2166~2179 (2014)
  10. Zhang B, "Association study identifying a new susceptibility gene(AUTS2)for schizophrenia", Int J Mol Sci, 15, pp.19406~19416 (2014)
  11. Chen YH, "Genetic analysis of AUTS2 as a susceptibility gene of heroin dependence", Drug Alcohol Depend, 128, pp.238~242 (2013)
  12. Dang W, "The evidence for the contribution of the autism susceptibility candidate 2(AUTS2)gene in heroin dependence susceptibility", J Mol Neurosci, 54, pp.811~819 (2014)
  13. Chojnicka I, "Possible association between suicide committed under influence of ethanol and a variant in the AUTS2 gene", PLoS One, 8, pp.e57199~ (2013)
  14. Schumann G, "Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene(AUTS2)in the regulation of alcohol consumption", Proc Natl AcadSci U S A, 108, pp.7119~7124 (2011)
  15. Cloninger CR, "A unified biosocial theory of personality and its role in the development of anxiety states", Psychiatr Dev, 4, pp.167~226 (1986)
  16. Cloninger CR, "A psychobiological model of temperament and character", Arch Gen Psychiatry, 50, pp.975~990 (1993)
  17. Narita S, "Association between AUTS2 haplotypes and alcohol dependence in a Japanese population", Acta Neuropsychiatr, 28, pp.214~220 (2016)
  18. Kijima N, "Cloninger’s seven-factor model of temperament and character and Japanese version of Temperament and Character Inventory(TCI)", Jpn J Psychiatr Diagn, 7, pp.379~399 (1996)
  19. O’Neil MK, "Life stress and depression in university students : clinical illustrations of recent research", J Am Coll Health, 36, pp.235~240 (1988)
  20. Spitzer RL, "Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire", JAMA, 282, pp.1737~1744 (1999)
  21. Kroenke K, "The PHQ-9 : validity of a brief depression severity measure", J Gen Intern Med, 16, pp.606~613 (2001)
  22. Kroenke K, "The PHQ-9 : a new depression diagnostic andseverity measure", Psychiatr Ann, 32, pp.509~521 (2002)
  23. Muramatsu K, "The patient health questionnaire, Japanese version: validity according to the mini-international neuropsychiatric interview-plus", Psychol Rep, 101, pp.952~960 (2007)
  24. Arroll B, "Validation of PHQ-2 and PHQ-9 to screen for major depression in the primary care population", Ann Fam Med, 8, pp.348~353 (2010)
  25. Inagaki M, "Validity of the Patient Health Questionnaire(PHQ)-9 and PHQ-2 in general internal medicine primary care at a Japanese rural hospital : a cross-sectional study", Gen Hosp Psychiatry, 35, pp.592~597 (2013)
  26. Barrett JC, "Haploview : analysis and visualization of LD and haplotype maps", Bioinformatics, 21, pp.263~265 (2005)
  27. Purcell S, "PLINK : a tool set for whole-genome association and population-based linkage analyses", Am J Hum Genet, 81, pp.559~575 (2007)
  28. Oksenberg N, "The role of AUTS2 in neurodevelopment and human evolution", Trends Genet, 29, pp.600~608 (2013)
  29. Myung W, "A genome-wide association study of antidepressant response in Koreans", Transl Psychiatry, 5, pp.e633~ (2015)
  30. Cloninger CR, "A systematic method for clinical description and classification of personality variants. A proposal", Arch Gen Psychiatry, 44, pp.573~588 (1987)
  31. Mattick JS, "The evolution of controlled multitasked gene networks : the role of introns and other noncoding RNAs in the development of complex organisms", Mol Biol Evol, 18, pp.1611~1630 (2001)
  32. Cohen J, "A power primer", Psychol Bull, 112, pp.155~159 (1992)
  33. Tsai SJ, "Norepinephrine transporter and alpha(2c)adrenoceptor allelic variants and personality factors", Am J Med Genet, 114, pp.649~651 (2002)
  34. Muramatsu K, "The patient health questionnaire(PHQ)-9 : a depression diagnostic and severity measure in primary care", Jpn J Psychiatr Treat, 23, pp.1299~1306 (2008)
  35. Löwe B, "Comparative validity of three screening questionnaires for DSM-IV depressive disorders and physicians’ diagnoses", J Affect Disord, 78, pp.131~140 (2004)

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