Relationship between Delusion of Theft and Cognitive Functions in Patients with Mild Alzheimer’s Disease
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Although delusion of theft (DT) is the most frequent type of delusion in Alzheimer’s disease (AD), its relationship to cognitive functions remains unclear. The aim of this study was to demonstrate the relationship between DT and cognitive functions in mild AD. Two hundred eighty-nine mild AD patients were enrolled in this study. These subjects were classified into three groups: patients with no delusions (ND, n=82), patients with paranoid delusions (PD, n=114) and patients with DT (n=93). Cognitive functions and their associations with the degree of delusion were compared among the three groups. The results showed that verbal Fluency scores were significantly lower in the PD group than in the DT and ND groups. Word List Recall scores were significantly lower in the DT group than in the PD and ND groups. Interestingly, delusion severity measured with the Neuropsychiatric Inventory delusion subscale correlated negatively with the Word List Recall scores in the DT group. In this study, we demonstrated that episodic memory functions in mild AD patients were associated with DT, but not with PD. Further studies might be needed to clarify the pathophysiology of delusions associated with AD.
Abstract
Although delusion of theft (DT) is the most frequent type of delusion in Alzheimer’s disease (AD), its relationship to cognitive functions remains unclear. The aim of this study was to demonstrate the relationship between DT and cognitive functions in mild AD. Two hundred eighty-nine mild AD patients were enrolled in this study. These subjects were classified into three groups: patients with no delusions (ND, n=82), patients with paranoid delusions (PD, n=114) and patients with DT (n=93). Cognitive functions and their associations with the degree of delusion were compared among the three groups. The results showed that verbal Fluency scores were significantly lower in the PD group than in the DT and ND groups. Word List Recall scores were significantly lower in the DT group than in the PD and ND groups. Interestingly, delusion severity measured with the Neuropsychiatric Inventory delusion subscale correlated negatively with the Word List Recall scores in the DT group. In this study, we demonstrated that episodic memory functions in mild AD patients were associated with DT, but not with PD. Further studies might be needed to clarify the pathophysiology of delusions associated with AD.
참고문헌 (16)
- Cipriani G, "Understanding delusion in dementia: a review", Geriatr Gerontol Int, 14, pp.32~39 (2014)[DOI]
- Ornstein K, "The differential impact of unique behavioral and psychological symptoms for the dementia caregiver: how and why do patients' individual symptom clusters impact caregiver depressive symptoms?", Am J Geriatr Psychiatry, 21, pp.1277~1286 (2013)[DOI]
- Apostolova LG, "Risk factors for behavioral abnormalities in mild cognitive impairment and mild Alzheimer's disease", Dement Geriatr Cogn Disord, 37, pp.315~326 (2014)[DOI]
- Zhao Q-F, "The prevalence of neuropsychiatric symptoms in Alzheimer's disease: systematic review and meta-analysis", J Affect Disord, 190, pp.264~271 (2016)[DOI]
- Holt AE, "Cognitive neuroscience of delusions in aging", Neuropsychiatr Dis Treat, 2, pp.181~189 (2006)[DOI]
- Jeste DV, "Cognitive deficits of patients with Alzheimer's disease with and without delusions", Am J Psychiatry, 149, pp.184~189 (1992)[DOI]
- Migliorelli R, "Neuropsychiatric and neuropsychological correlates of delusions in Alzheimer's disease", Psychol Med, 25, pp.505~513 (1995)[DOI]
- McKhann GM, "The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease", Alzheimer Dement, 7, pp.263~269 (2011)[DOI]
- Morris JC, "Clinical dementia rating: a reliable and valid diagnostic and staging measure for dementia of the Alzheimer type", Int Psychogeriatr, 9(Suppl 1), pp.173~176 (1997)[DOI]
- Lee JH, "Development of the Korean version of the Consortium to Establish a Registry for Alzheimer's Disease Assessment Packet (CERAD-K): clinical and neuropsychological assessment batteries", J Gerontol B Psychol Sci Soc Sci, 57, pp.P47~P53 (2002)[DOI]
- Cummings JL, "The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia", Neurology, 44, pp.2308~2314 (1994)[DOI]
- Geroldi C, "Temporal lobe asymmetry in patients with Alzheimer's disease with delusions", J Neurol Neurosurg Psychiatry, 69, pp.187~191 (2000)[DOI]
- Fukuhara R, "Alteration of rCBF in Alzheimer's disease patients with delusions of theft", Neuroreport, 12, pp.2473~2476 (2001)[DOI]
- Murayama N, "Risk factors for delusion of theft in patients with Alzheimer's disease showing mild dementia in Japan", Aging Ment Health, 13, pp.563~568 (2009)[DOI]
- Kazui H, "Symptoms underlying unawareness of memory impairment in patients with mild Alzheimer's disease", J Geriatr Psychiatry Neurol, 19, pp.3~12 (2006)[DOI]
- Ostling S, "Cognitive test performance in relation to psychotic symptoms and paranoid ideation in non-demented 85-year-olds", Psychol Med, 34, pp.443~450 (2004)[DOI]