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양극성장애 부모의 자녀에서 정신 질환

Mental Disorders in Offspring of Parents with Bipolar Disorder

권영준|이화영|심세훈|정희연|신정이|조영성
대한신경정신의학회 (Korean Neuropsychiatric Association)|2014.09|신경정신의학 (JOURNAL OF THE KOREAN NEUROPSYCHIATRIC ASSOCIATION)|제53권 제5호|pp. 310-319|DOI http://dx.doi.org/10.4306/jknpa.2014.53.5.310

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키워드

자녀청소년Adolescent양극성장애Bipolar disorderChild소아Offspring
주제분류정신과학

초록

양극성장애 부모의 자녀들에서 보이는 정신장애의 비율 및동반 질환, 임상평가척도 등을 분석한 결과, 정동장애를 포함한 기타 정신의학적 질환의 유병률이 높고 행동장애의 동반비율이 높으며 주관적 우울, 불안 정도가 높음이 밝혀졌다. 이는 기존의 연구들과 방향을 같이 하는 결과로서 부모의 양극성장애는 자녀에 있어 정신장애의 발병을 예측할 수 있는요인으로 생각해 볼 수 있겠다. 그러므로 양극성장애 환자를치료하는 임상가들은 그 자녀들의 정신병리에 대해서도 주의 깊게 살펴보아야 하며, 행동문제에 있어서도 양극성장애의 감별을 염두에 두고 조기개입, 조기치료를 통하여 자녀들의 정신장애를 약화시키거나 예방할 수 있어야 할 것이다. 또한 이러한 고위험군에 있어서는 대규모 종적 연구가 활발히진행되어야 할 것이다.

Abstract

Objectives Information on the specificity of associations between parents with bipolar disorder (BPD) and risk of psychopathology in their offspring is limited. The aim of this study was to examine the prevalence of mental disorders in the offspring of individuals with BPD in South Korea. Methods The sample consisted of 100 child and adolescent offspring (aged 6.0–18.9 years) from 65 nuclear families having at least one parent with BPD. Probands, offspring, and biological co-parents were interviewed using a semi-structured diagnostic interview and the offspring were evaluated using the Korean version of the Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version (K-SADS-PL). Results Sixty one of the 100 participants met the criteria for at least one mental disorder. Of these, 35 participants had a mood disorder, 35 had an anxiety disorder, and 29 had attention-deficit hyperactivity disorder (ADHD). Thirty nine of the offspring had no psychiatric diagnosis. Of the 35 with a mood disorder, 16 (45.7%) had comorbid ADHD and 18 (51.4%) had comorbid anxiety disorders. Conclusion Offspring of parents with BPD are at high risk for mental disorders. These findings further support the heredity of BPD and indicate the need for early identification and treatment.

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