Clinical Characteristics and Psychotropic Drug Prescription Patterns of Bipolar Disorder Patients with a History of Suicidal Attempts: Findings from the REAP-BD, Korea
1
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Our study aimed to analyze the clinical characteristics and psychotropic prescription patterns of a history of suicide attempts in South Koreans with bipolar disorder (BD), by using only Korean data from the Research on Asian Psychotropic Prescription Pattern for Bipolar disorder. The patterns of clinical characteristics and psychotropic drug use were compared among 53 patients with a history of suicide attempts and 297 without this history; the potential effects of confounding variables were adjusted with binary logistic analyses for discrete variables and analyses of covariance for continuous variables. After adjusting the effects of age, sex, duration of illness, and enrollment as an outpatient, patients with a history of suicide attempts were characterized by a significantly more prevalent depressive episode, lower prevalent remission state, lower levels of hemoglobin, and more use of antidepressants, anxiolytics, and hypnotics compared to those without lifetime suicide attempt. The inability to plan goal-directed behavior may be an intervening factor in the relationship between suicide attempts and depression in BD. Relatively low hemoglobin levels can be associated with manic episodes in patients with a history of suicide attempts and the use of antidepressants, anxiolytics, or hypnotics can be associated with suicide attempts in BD patients.
Abstract
Our study aimed to analyze the clinical characteristics and psychotropic prescription patterns of a history of suicide attempts in South Koreans with bipolar disorder (BD), by using only Korean data from the Research on Asian Psychotropic Prescription Pattern for Bipolar disorder. The patterns of clinical characteristics and psychotropic drug use were compared among 53 patients with a history of suicide attempts and 297 without this history; the potential effects of confounding variables were adjusted with binary logistic analyses for discrete variables and analyses of covariance for continuous variables. After adjusting the effects of age, sex, duration of illness, and enrollment as an outpatient, patients with a history of suicide attempts were characterized by a significantly more prevalent depressive episode, lower prevalent remission state, lower levels of hemoglobin, and more use of antidepressants, anxiolytics, and hypnotics compared to those without lifetime suicide attempt. The inability to plan goal-directed behavior may be an intervening factor in the relationship between suicide attempts and depression in BD. Relatively low hemoglobin levels can be associated with manic episodes in patients with a history of suicide attempts and the use of antidepressants, anxiolytics, or hypnotics can be associated with suicide attempts in BD patients.
참고문헌 (19)
- Zhongde Pan, "Detecting Manic State of Bipolar Disorder Based on Support Vector Machine and Gaussian Mixture Model Using Spontaneous Speech", PSYCHIATRY INVESTIGATION, 15(7), pp.695~700 (2018), 대한신경정신의학회[DOI]
- Ather Muneer, "The Staging of Major Mood Disorders: Clinical and Neurobiological Correlates", PSYCHIATRY INVESTIGATION, 15(8), pp.747~758 (2018), 대한신경정신의학회[DOI]
- Plans L, "Association between completed suicide and bipolar disorder : A systemic review of the literature", J Affect Disord, 242, pp.111~122 (2019)
- Diagnostic and Statistical Manual of Mental Disorders, "American Psychiatric Association", American Psychiatric Association, ~ (1994)
- Dell’Osso B, "Clinical characterization of Italian suicide attempters with bipolar disorder", CNS Spectr, 23, pp.271~277 (2018)
- Benard V, "Sleep and circadian rhythms as possible trait marker of suicidal attempt in bipolar disorders : an actigraphy study", J Affect Disord, 244, pp.1~8 (2019)
- World Health Organization, "The ICD-10 Classification of Mental and Behavioral Disorders, Clinical Descriptions and Diagnostic Guidelines", World Health Organization, ~ (1992)
- Kim H, "Classification of attempted suicide by cluster analysis : A study of 888 suicide attempters presenting to the emergency department", J Affect Disord, 235, pp.184~190 (2018)
- Dunner D, "Clinical factors in lithium carbonate prophylaxis failure", Arch Gen Psychiatry, 30, pp.229~233 (1974)
- Fellinger M, "Seasonality in bipolar disorder : effect of sex and age", J Affect Disord, 24, pp.322~326 (2019)
- "Anatomical Therapeutic Chemical (ATC) Classification System"[URL]
- Dilsaver SC, "Suicidality, panic disorder and psychosis in bipolar depression, depressive-mania and pure-mania", Psychiatry Res, 73, pp.47~56 (1997)
- Benedetti F, "Opposite effects of suicidality and lithium on gray matter volumes in bipolar depression", J Affect Disord, 135, pp.139~147 (2011)
- Benedetti F, "Effects of CLOCK gene variants and early stress on hopelessness and suicide in bipolar depression", Chronobiol Int, 32, pp.1156~1161 (2015)
- Korkmaz S, "Frequency of anemia in chronic psychiatry patients", Neuropsychiatr Dis Treat, 11, pp.2737~2741 (2015)
- Wysokinski A, "Red blood cells parameters in patients with acute schizophrenia, unipolar depression and bipolar disorder", Psychiatr Danub, 30, pp.323~330 (2018)
- Toffol E, "Lithium is associated with decrease in all-cause and suicide mortality in high-risk bipolar patients : a nationwide registry-based prospective cohort study", J Affect Disord, 183, pp.159~165 (2015)
- Bowden CL, "The use of antidepressants in bipolar disorder patients with depression", Expert Opin Pharmacother, 17, pp.17~25 (2016)
- Diagnostic and Statistical Manual of Mental Disorders, "American Psychiatric Association", American Psychiatric Association, ~ (2013)