Examining Patterns of Polypharmacy in Bipolar Disorder: Findings from the REAP-BD, Korea
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초록
Based on Korean data from the Research on Asian Psychotropic Prescription Pattern for Bipolar Disorder, this study tried to present prescription patterns in biopolar disorder (BD) and its associated clinical features. Based on the information obtained from the study with structured questions, the tendency of prescription pattern was studied and analyzed. Polypharmacy was predominant, including simple polypharmacy in 51.1% and complex polypharmacy in 34.2% of patients. Subjects associated with simple or complex polypharmacy were significantly younger, had higher inpatient settings, a larger portion of onset with manic episode, a shorter duration of untreated illness, a shorter duration of current episode, were more overweight, used less antidepressants and used more anxiolytics. These findings can suggest higher polypharmacy rate in more severe BD and highlight the necessity of monitoring the weight of subjects with polypharmacy.
Abstract
Based on Korean data from the Research on Asian Psychotropic Prescription Pattern for Bipolar Disorder, this study tried to present prescription patterns in biopolar disorder (BD) and its associated clinical features. Based on the information obtained from the study with structured questions, the tendency of prescription pattern was studied and analyzed. Polypharmacy was predominant, including simple polypharmacy in 51.1% and complex polypharmacy in 34.2% of patients. Subjects associated with simple or complex polypharmacy were significantly younger, had higher inpatient settings, a larger portion of onset with manic episode, a shorter duration of untreated illness, a shorter duration of current episode, were more overweight, used less antidepressants and used more anxiolytics. These findings can suggest higher polypharmacy rate in more severe BD and highlight the necessity of monitoring the weight of subjects with polypharmacy.
참고문헌 (30)
- "Global Burden of Disease Study 2013 Collaborators Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013", Lancet, 386, pp.743~800 (2015)
- Crump C, "Comorbidities and mortality in bipolar disorder : a Swedish national cohort study", JAMA Psychiatry, 70, pp.931~939 (2013)
- Phillips ML, "Bipolar disorder diagnosis : challenges and future directions", Lancet, 381, pp.1663~1671 (2013)
- Grande I, "Bipolar disorder", Lancet, 387, pp.1561~1572 (2016)
- Fountoulakis KN, "The International College of Neuro-Psychopharmacology(CINP)Treatment Guidelines for Bipolar Disorder in Adults(CINP-BD-2017), Part 3 : The Clinical Guidelines", Int J Neuropsychopharmacol, 20, pp.180~195 (2017)
- Yatham LN, "Canadian Network for Mood and Anxiety Treatments(CANMAT)and International Society for Bipolar Disorders(ISBD)2018 guidelines for the management of patients with bipolar disorder", Bipolar Disord, 20, pp.97~170 (2018)
- Goodwin GM, "Evidence-based guidelines for treating bipolar disorder : Revised third edition recommendations from the British Association for Psychopharmacology", J Psychopharmacol, 30, pp.495~553 (2016)
- Malhi GS, "Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders", Aust N Z J Psychiatry, 49, pp.1087~1206 (2015)
- Puyat JH, "Ethnic disparities in antipsychotic drug use in British Columbia : a cross-sectional retrospective study", Psychiatr Serv, 62, pp.1026~1031 (2011)
- Weymann D, "High-cost users of prescription drugs : a population-based analysis from British Columbia, Canada", Health Serv Res, 52, pp.697~719 (2017)
- Greil W, "Pharmacotherapeutic trends in 2231 psychiatric inpatients with bipolar depression from the International AMSP Project between 1994 and 2009", J Affect Disord, 136, pp.534~542 (2012)
- Walpoth-Niederwanger M, "Treatment patterns in inpatients with bipolar disorder at a psychiatric university hospital over a 9-year period : focus on mood stabilizers", Int Clin Psychopharmacol, 27, pp.256~266 (2012)
- World Health Organization, "The ICD-10 Classification of Mental and Behavioral Disorders, Clinical Descriptions and Diagnostic Guidelines", World Health Organization, ~ (1992)
- "Anatomical Therapeutic Chemical (ATC) classification system"[URL]
- Goldberg JF, "Depressive illness burden associated with complex polypharmacy in patients with bipolar disorder : findings from the STEP-BD", J Clin Psychiatry, 70, pp.155~162 (2009)
- Dunner DL, "Clinical factors in lithium carbonate prophylaxis failure", Arch Gen Psychiatry, 30, pp.229~233 (1974)
- Fellinger M, "Seasonality in bipolar disorder : Effect of sex and age", J Affect Disord, 243, pp.322~326 (2019)
- Strakowski SM, "CANMAT and ISBD 2018 guidelines for the management of patients with bipolar disorder", Bipolar Disord, 20, pp.393~394 (2018)
- Ketter TA, "Monotherapy versus combined treatment with second-generation antipsychotics in bipolar disorder", J Clin Psychiatry, (69 Suppl 5), pp.9~15 (2008)
- Lin D, "Polytherapy in bipolar disorder", CNS Drugs, 20, pp.29~42 (2006)
- Belizario GO, "Impact of predominant polarity on longterm outcome in bipolar disorder : A 7-year longitudinal cohort study", J Affect Disord, 241, pp.37~40 (2018)
- Carvalho AF, "Predominant polarity as a course specifier for bipolar disorder : a systematic review", J Affect Disord, 163, pp.56~64 (2014)
- Henry C, "Anxiety disorders in 318 bipolar patients : prevalence and impact on illness severity and response to mood stabilizer", J Clin Psychiatry, 64, pp.331~335 (2003)
- Yapici Eser H, "Prevalence and associated features of anxiety disorder comorbidity in bipolar disorder : a meta-analysis and meta-regression study", Front Psychiatry, 9, pp.229~ (2018)
- 윤운, "Antidepressant Prescription Patterns in Bipolar Disorder: a Nationwide, Register-based Study in Korea", Journal of Korean Medical Science, 33(46), pp.1~11 (2018), 대한의학회
- Bond DJ, "Diagnosis and body mass index effects on hippocampal volumes and neurochemistry in bipolar disorder", Transl Psychiatry, 7, pp.e1071~ (2017)
- Hu C, "Trajectories of body mass index change in first episode of mania: 3-year data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM)", J Affect Disord, 208, pp.291~297 (2017)
- Bauer M, "Areas of uncertainties and unmet needs in bipolar disorders : clinical and research perspectives", Lancet Psychiatry, 5, pp.930~939 (2018)
- Giampaolo Perna, "Short-Term Psychiatric Rehabilitation in Major Depressive and Bipolar Disorders: Neuropsychological-Psychosocial Outcomes", PSYCHIATRY INVESTIGATION, 14(1), pp.8~15 (2017), 대한신경정신의학회[DOI]