Platelet Serotonin Concentration Is Associated with Illness Duration in Schizophrenia and Chronological Age in Depression
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Objective Impaired serotonergic neurotransmission has been implicated in the pathogenesis of depression and schizophrenia. Blood platelets have been used for years as a peripheral model of neuronal serotonin dynamics. The objective was to investigate platelet count and serotonin concentration in patients with depression and schizophrenia, in an attempt to ascertain their clinical usefulness.Methods 953 participants were included in the study, 329 patients with depression, 339 patients with schizophrenia and 285 healthy controls. ELISA was used to assess platelet serotonin concentrations.Results There were no statistically significant differences among groups regarding age, total platelet count and serotonin concentration. Linear regression analyses revealed inverse correlations between platelet serotonin concentration and age of patients with depression and healthy individuals, as well as between platelet serotonin concentration and illness duration in patients with schizophrenia. In other words, longer illness duration in patients with schizophrenia, and higher age in patients with depression and healthy individuals was associated with lower platelet serotonin concentrations.Conclusion Platelet count and serotonin concentration did not prove to be of diagnostic value in differentiating patients and healthy individuals. However, illness duration in patients with schizophrenia may be associated with reduced concentrations of platelet serotonin.
Abstract
Objective Impaired serotonergic neurotransmission has been implicated in the pathogenesis of depression and schizophrenia. Blood platelets have been used for years as a peripheral model of neuronal serotonin dynamics. The objective was to investigate platelet count and serotonin concentration in patients with depression and schizophrenia, in an attempt to ascertain their clinical usefulness.Methods 953 participants were included in the study, 329 patients with depression, 339 patients with schizophrenia and 285 healthy controls. ELISA was used to assess platelet serotonin concentrations.Results There were no statistically significant differences among groups regarding age, total platelet count and serotonin concentration. Linear regression analyses revealed inverse correlations between platelet serotonin concentration and age of patients with depression and healthy individuals, as well as between platelet serotonin concentration and illness duration in patients with schizophrenia. In other words, longer illness duration in patients with schizophrenia, and higher age in patients with depression and healthy individuals was associated with lower platelet serotonin concentrations.Conclusion Platelet count and serotonin concentration did not prove to be of diagnostic value in differentiating patients and healthy individuals. However, illness duration in patients with schizophrenia may be associated with reduced concentrations of platelet serotonin.
참고문헌 (52)
- Galvez-Contreras AY, "Growth factors as clinical biomarkers of prognosis and diagnosis in psychiatric disorders", Cytokine Growth Factor Rev, 32, pp.85~96 (2016)
- Gururajan A, "Molecular biomarkers of depression", Neurosci Biobehav Rev, 64, pp.101~133 (2016)
- Lai CY, "Biomarkers in schizophrenia : a focus on blood based diagnostics and theranostics", World J Psychiatry, 6, pp.102~117 (2016)
- Okazaki S, "The cell cycle-related genes as biomarkers for schizophrenia", Prog Neuropsychopharmacol Biol Psychiatry, 70, pp.85~91 (2016)
- Karlović D, "Serum concentrations of CRP, Il-6, TNF-α, and cortisol in major depressive disorder with melancholic or atypical features", Psychiatry Res, 198, pp.74~80 (2012)
- Silić A, "Increased inflammation and lower platelet 5-HT in depression with metabolic syndrome", J Affect Disord, 141, pp.72~78 (2012)
- Lakhan SE, "Biomarkers in psychiatry : drawbacks and potential for misuse", Int Arch Med, 3, pp.1~ (2010)
- Maes M, "Psychopharmacology: The fourth Generation of Progress", pp.933~944 (1995), Raven Press
- Abi-Dargham A, "The role of serotonin in the pathophysiology and treatment of schizophrenia", J Neuropsychiatry Clin Neurosci, 9, pp.1~17 (1997)
- Javitt DC, "Textbook of Schizophrenia", pp.85~116 (2006), American Psychiatric Publishing Inc
- Lopez-Munoz F, "Monoaminergic neurotransmission : the history of the discovery of antidepressants from 1950s until today", Curr Pharm Des, 15, pp.1563~1586 (2009)
- Stahl SM, "Platelets: Physiology and Pharmacology", pp.307~340 (1985), Academic Press
- Muck-Seler D, "Platelet serotonin and plasma prolactin and cortisol in healthy, depressed and schizophrenic women", Psychiatry Res, 127, pp.217~226 (2004)
- Balija M, "Serotonin level and serotonin uptake in human platelets : a variable interrelation under marked physiological influences", Clin Chim Acta, 412, pp.299~304 (2011)
- Austin MC, "Expression of serotonin transporter messenger RNA in the human brain", J Neurochem, 62, pp.2362~2367 (1994)
- Mercado CP, "Molecular mechanisms of SERT in platelets : regulation of plasma serotonin levels", Mol Interv, 10, pp.231~241 (2010)
- Hervig TA, "Endogenous serotonin in human blood platelets : factors that may influence reference values", Platelets, 7, pp.47~52 (1996)
- Le Blanc J, "Platelet function in aging", Front Cardiovasc Med, 6, pp.109~ (2019)
- Gleerup G, "The effect of ageing on human platelet sensitivity to serotonin", Eur J Clin Invest, 18, pp.504~506 (1988)
- Flachaire E, "Determination of reference values for serotonin concentration in platelets of healthy newborns, children, adults, and elderly subjects by HPLC with electrochemical detection", Clin Chem, 36, pp.2117~2120 (1990)
- Sagud M, "A prospective, longitudinal study of platelet serotonin and plasma brain-derived neurotrophic factor concentrations in major depression: effects of vortioxetine treatment", Psychopharmacology(Berl), 233, pp.3259~3267 (2016)
- Muck-Seler D, "Sex differences, season of birth and platelet 5-HT levels in schizophrenic patients", J Neural Transm(Vienna), 106, pp.337~347 (1999)
- Kaneda Y, "Platelet serotonin concentrations in medicated schizophrenic patients", Prog Neuropsychopharmacol Biol Psychiatry, 25, pp.983~992 (2001)
- Ruljancic N, "Platelet serotonin and magnesium concentrations in suicidal and non-suicidal depressed patients", Magnes Res, 26, pp.9~17 (2013)
- Moreno J, "Tryptophan and serotonin in blood and platelets of depressed patients : effect of an antidepressant treatment", Salud Ment, 29, pp.1~8 (2006)
- Mück-Seler D, "Platelet 5-HT concentrations and suicidal behaviour in recurrent major depression", J Affect Disord, 39, pp.73~80 (1996)
- Braunig P, "Blood serotonin levels in suicidal schizophrenic patients", Acta Psychiatr Scand, 79, pp.186~189 (1989)
- van Kempen GM, "Repeated measures of platelet MAO activity and 5-HT in a group of suicidal women", Biol Psychiatry, 31, pp.529~530 (1992)
- Pivac N, "Hypothalamic-pituitary-adrenal axis function and platelet serotonin concentrations in depressed patients", Psychiatry Res, 73, pp.123~132 (1997)
- Rao ML, "Upregulation of the platelet Serotonin2A receptor and low blood serotonin in suicidal psychiatric patients", Neuropsychobiology, 38, pp.84~89 (1998)
- Alvarez JC, "Low blood cholesterol and low platelet serotonin levels in violent suicide attempters", Biol Psychiatry, 45, pp.1066~1069 (1999)
- Anderson GM, "Peripheral and central neurochemical effects of the selective serotonin reuptake inhibitors(SSRIs)in humans and nonhuman primates : assessing bioeffect and mechanisms of action", Int J Dev Neurosci, 22, pp.397~404 (2004)
- Muck Šeler D, "Trends in Serotonin Uptake Inhibitors Research", pp.29~53 (2005), Nova Science Publishers Inc
- Maurer-Spurej E, "Platelet serotonin levels support depression scores for women with postpartum depression", J Psychiatry Neurosci, 32, pp.23~29 (2007)
- Zhuang X, "Platelet serotonin and serotonin transporter as peripheral surrogates in depression and anxiety patients", Eur J Pharmacol, 834, pp.213~220 (2018)
- Figueras G, "Pretreatment platelet 5-HT concentration predicts the short-term response to paroxetine in major depression", Grupo de Trastornos Afectivos. Biol Psychiatry, 46, pp.518~524 (1999)
- Mück-Seler D, "The effects of paroxetine and tianeptine on peripheral biochemical markers in major depression", Prog Neuropsychopharmacol Biol Psychiatry, 26, pp.1235~1243 (2002)
- Mészáros Z, "MAO inhibitory side effects of neuroleptics and platelet serotonin content in schizophrenic patients", J Neural Transm, 52(Suppl), pp.79~85 (1998)
- Ertugrul A, "Influence of clozapine on platelet serotonin, monoamino oxidase and plasma serotonin levels", Psychiatry Res, 149, pp.49~57 (2007)
- Muck-Seler D, "Platelet serotonin subtypes of schizophrenia and unipolar depression", Psychiatry Res, 38, pp.105~113 (1991)
- Peitl V, "Platelet serotonin concentration and depressive symptoms in patients with schizophrenia", Psychiatry Res, 239, pp.105~110 (2016)
- Brusov OS, "Parameters of platelet serotonin system in patients with schizophrenia treated with olanzapine : a search for the serotonergic predictors of therapeutic efficacy", Zh Nevrol Psikhiatr Im S S Korsakova, 105, pp.27~34 (2005)
- Marcinko D, "Platelet serotonin and serum cholesterol concentrations in suicidal and non-suicidal male patients with a first episode of psychosis", Psychiatry Res, 150, pp.105~108 (2007)
- van der Heijden FM, "Atypical antipsychotics and the relevance of glutamate and serotonin", Eur Neuropsychopharmacol, 14, pp.259~265 (2004)
- Sacchetti E, "Adherence to Antipsychotics in Schizophrenia", pp.1~29 (2014), Springer-Verlag
- Kay SR, "The positive and negative syndrome scale(PANSS)for schizophrenia", Schizophr Bull, 13, pp.261~276 (1987)
- Hedlund JL, "The Hamilton rating scale for depression: a comprehensive review", J Oper Psychiatry, 10, pp.149~165 (1979)
- Sheehan DV, "The Mini-International Neuropsychiatric Interview (M.I.N.I.):the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10", J Clin Psychiatry, 59(Suppl 20), pp.34~57 (1998)
- Livingston JD, "Correlates and consequences of internalized stigma for people living with mental illness : a systematic review and meta-analysis", Soc Sci Med, 71, pp.2150~2161 (2010)
- Quednow BB, "Handbook of Behavioral Neurobiology of Serotonin", pp.585~620 (2010), Elsevier BV
- Eggers AE, "A serotonin hypothesis of schizophrenia", Med Hypotheses, 80, pp.791~794 (2013)
- 김성완, "Psychosocial Factors Contributing to Suicidal Ideation in Hospitalized Schizophrenia Patients in Korea", PSYCHIATRY INVESTIGATION, 7(2), pp.79~85 (2010), 대한신경정신의학회
