Effects of dietary supplementation of vitamin A on the tibia quality of goslings
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Objective: This study was conducted to evaluate the effect of dietary supplementation of vitamin A (VA) on the tibial growth, calcium (Ca) and phosphorus (P) metabolism, VA, and vitamin D (VD) deposition, and associated gene expression in goslings.Methods: A total of 180 healthy, 1-day-old male goslings were randomly divided into 3 treatment groups (0, 9,000, and 15,000 IU VA/kg), with 6 replicates containing 10 goslings each. They were weighed and sampled on days 14, 28, 42, 56, and 70.Results: No addition of VA reduced VA content in the serum and liver of goslings, and supplementation of 15,000 IU/kg VA increased VA content from day 14 (p<0.05). The trend of VA concentration in the serum and liver was in line with the relative mRNA expression of retinoic acid receptor β in the jejunal mucosa. In both no addition of VA and supplementation of 15,000 IU/kg VA reduced 25-hydroxycholecalciferol (25-OH-VD3) content in the serum and VD content in the liver (p<0.05). From day 28, no addition of VA or supplementation of 15,000 IU/kg VA had a negative effect on tibia length, strength, and Ca, P, and ash content in goslings (p<0.05). Tibia P content was lower in the supplementation of 15,000 IU/kg VA group than in the no addition of VA group (p<0.05). No addition of VA or supplementation of 15,000 IU/kg VA had the most effect on early serum parathyroid hormone (PTH) levels in goslings (p<0.05). The effect of no addition of VA on the bone Gla protein (BGP) content of goslings started from day 14 (p<0.05). The relative mRNA expression of bone Gla-protein (<i>BGLAP</i>) and bone morphogenetic protein 4 (<i>BMP4</i>) in the liver and jejunal mucosa was decreased by either no addition of VA or supplementation of 15,000 IU/kg VA (p<0.05).Conclusion: Both no addition of VA and supplementation of 15,000 IU/kg VA affected the mineralization process of the bone, and ultimately reduced tibial quality.
Abstract
Objective: This study was conducted to evaluate the effect of dietary supplementation of vitamin A (VA) on the tibial growth, calcium (Ca) and phosphorus (P) metabolism, VA, and vitamin D (VD) deposition, and associated gene expression in goslings. Methods: A total of 180 healthy, 1-day-old male goslings were randomly divided into 3 treatment groups (0, 9,000, and 15,000 IU VA/kg), with 6 replicates containing 10 goslings each. They were weighed and sampled on days 14, 28, 42, 56, and 70. Results: No addition of VA reduced VA content in the serum and liver of goslings, and supplementation of 15,000 IU/kg VA increased VA content from day 14 (p<0.05). The trend of VA concentration in the serum and liver was in line with the relative mRNA expression of retinoic acid receptor β in the jejunal mucosa. In both no addition of VA and supplementation of 15,000 IU/kg VA reduced 25-hydroxycholecalciferol (25-OH-VD3) content in the serum and VD content in the liver (p<0.05). From day 28, no addition of VA or supplementation of 15,000 IU/kg VA had a negative effect on tibia length, strength, and Ca, P, and ash content in goslings (p<0.05). Tibia P content was lower in the supplementation of 15,000 IU/kg VA group than in the no addition of VA group (p<0.05). No addition of VA or supplementation of 15,000 IU/kg VA had the most effect on early serum parathyroid hormone (PTH) levels in goslings (p<0.05). The effect of no addition of VA on the bone Gla protein (BGP) content of goslings started from day 14 (p<0.05). The relative mRNA expression of bone Gla-protein (BGLAP) and bone morphogenetic protein 4 (BMP4) in the liver and jejunal mucosa was decreased by either no addition of VA or supplementation of 15,000 IU/kg VA (p<0.05). Conclusion: Both no addition of VA and supplementation of 15,000 IU/kg VA affected the mineralization process of the bone, and ultimately reduced tibial quality.
참고문헌 (40)
- Rath NC, "Sturkie's avian physiology", pp.529~543 (2022), Academic Press
- Yang Q, "Untargeted metabolomics study on the effects of rearing ducks in cages on bone quality", Poult Sci, 101, pp.101604~ (2022)[DOI]
- Onbaşılar EE, "Comparison of liver and bone health of two laying hen strains kept in different cage systems", Eur Poult Sci, 80, pp.123~ (2016)[DOI]
- Green AC, "The role of vitamin A and retinoic acid receptor signaling in post-natal maintenance of bone", J Steroid Biochem Mol Biol, 155, pp.135~146 (2016)[DOI]
- Pilch SM, "Analysis of vitamin A data from the health and nutrition examination surveys", J Nutr, 117, pp.636~640 (1987)[DOI]
- Uni Z, "Vitamin A deficiency interferes with proliferation and maturation of cells in the chicken small intestine", Br Poult Sci, 41, pp.410~415 (2000)[DOI]
- National Research Council(NRC), "Nutrient requirements of poultry" (1994), The National Academies Press
- Yan SM, "Effects of vitamin A and vitamin D on metabolism of calcium and phosphorous in broilers", Chin J Anim Nutr, 19, pp.218~224 (2007)
- Lind T, "Excessive dietary intake of vitamin A reduces skull bone thickness in mice", PLoS One, 12, pp.e0176217~ (2017)[DOI]
- Rohde CM, "Bone resorption activity of all-trans retinoic acid is independent of vitamin D in rats", J Nutr, 133, pp.777~783 (2003)[DOI]
- Conaway HH, "Vitamin a metabolism, action, and role in skeletal homeostasis", Endocr Rev, 34, pp.766~797 (2013)[DOI]
- Johansson S, "Vitamin A antagonizes calcium response to vitamin D in man", J Bone Miner Res, 16, pp.1899~1905 (2001)[DOI]
- Rohde CM, "Vitamin A antagonizes the action of vitamin D in rats", J Nutr, 129, pp.2246~2250 (1999)[DOI]
- Metz AL, "The interaction of dietary vitamin A and vitamin D related to skeletal development in the turkey poult", J Nutr, 115, pp.929~935 (1985)[DOI]
- Daniel DB, "Vitamin D metabolism, mechanism of action, and clinical applications", Chem Biol, 21, pp.319~329 (2014)[DOI]
- Levin AA, "9-cis retinoic acid stereoisomer binds and activates the nuclear receptor RXR alpha", Nature, 355, pp.359~361 (1992)[DOI]
- Liang JR, "Assessment of vitamin A requirement of gosling in 0-28 d based on growth performance and bone indexes", Poult Sci, 100, pp.101015~ (2021)[DOI]
- Shi SR, "Nitrogen requirement for maintenance in Yangzhou goslings", Br Poult Sci, 48, pp.205~209 (2007)[DOI]
- Wang ZY, "Response of growing goslings to dietary methionine from 28 to 70 days of age", Br Poult Sci, 51, pp.118~121 (2010)[DOI]
- Liang JR, "The effect of dietary vitamin A supplementation in maternal and its offspring on the early growth performance, liver vitamin A content, and antioxidant index of goslings", Poult Sci, 98, pp.6849~6856 (2019)[DOI]
- Xiao X, "Vitamin A deficiency or critical excess has negative effects on the growth performance, slaughter performance, and meat quality of goslings", Anim Feed Sci Technol, 280, pp.115064~ (2021)[DOI]
- Guo S, "Interactive effects of vitamins A and K3 on laying performance, egg quality, tibia attributes and antioxidative status of aged Roman Pink laying hens", Animal, 15, pp.100242~ (2021)[DOI]
- Association of Official Analytical Chemists (AOAC), "Official methods of analysis of AOAC international" (1995), AOAC International
- Blomhoff R, "Vitamin A metabolism : new perspectives on absorption, transport, and storage", Physiol Rev, 71, pp.951~990 (1991)[DOI]
- Wang J, "Effect of dietary 25-hydroxycholecalciferol supplementation and high stocking density on performance, egg quality, and tibia quality in laying hens", Poult Sci, 99, pp.2608~2615 (2020)[DOI]
- Kodaka T, "Local disappearance of epiphyseal growth plates in rats with hypervitaminosis A", J Vet Med Sci, 60, pp.815~821 (1998)[DOI]
- Guo X, "Effect of excessive vitamin A on alkaline phosphatase activity and concentrations of calcium-binding protein and bone Gal-protein in culture medium and CaBP mRNA expression in osteoblasts of broiler chickens", Asian-Australas J Anim Sci, 24, pp.239~245 (2011)[DOI]
- Zhang HY, "Study on the morphology and mineralization of the tibia in meat ducks from 1 to 56 d", Poult Sci, 98, pp.3355~3364 (2019)[DOI]
- Shim MY, "The effects of growth rate on leg morphology and tibia breaking strength, mineral density, mineral content, and bone ash in broilers", Poult Sci, 91, pp.1790~1795 (2012)[DOI]
- Aburto A, "Effects and interactions of dietary levels of vitamins A and E and cholecalciferol in broiler chickens", Poult Sci, 775, pp.666~673 (1998)[DOI]
- Stevens VI, "Dietary levels of fat, calcium, and vitamins A and D3 as contributory factors to rickets in poults", Poult Sci, 62, pp.2073~2082 (1983)[DOI]
- Mir NA, "Effect of feeding different levels of zinc and vitamin A on morphometry and mineralization of tibia bone in broiler chickens", Indian J Poult Sci, 49, pp.224~227 (2014)
- Ferrone F, "The relative influence of serum ionized calcium and 25-hydroxyvitamin D in regulating PTH secretion in healthy subjects", Bone, 125, pp.200~206 (2019)[DOI]
- Ikeda K, "Conditional expression of human bone Gla protein in osteoblasts causes skeletal abnormality in mice", Biochem Biophys Res Commun, 424, pp.164~169 (2012)[DOI]
- Xu A, "Post-translational modification of retinoic acid receptor alpha and its roles in tumor cell differentiation", Biochem Pharmacol, 171, pp.113696~ (2020)[DOI]
- Li N, "Suppression of retinoic acid receptors may contribute to embryonic skeleton hypoplasia in maternal rats with chronic vitamin A deficiency", J Nutr Biochem, 21, pp.710~716 (2010)[DOI]
- Chatterjee S, "et al Enhancer variants synergistically drive dysfunction of a gene regulatory network in Hirschsprung disease", Cell, 167, pp.355~368 (2016)[DOI]
- Kirimoto A, "Effects of retinoic acid on the differentiation of chondrogenic progenitor cells, ATDC5", J Med Dent Sci, 52, pp.153~162 (2005)[DOI]
- Wang Y, "BMP and RA signaling cooperate to regulate Apolipoprotein C1 expression during embryonic development", Gene, 554, pp.196~204 (2015)[DOI]
- Yu M, "BMP4 mutations in tooth agenesis and low bone mass", Arch Oral Biol, 103, pp.40~46 (2019)[DOI]