본문 바로가기
KERD
논문KCI 등재

Methamphetamine Use Disorder and Inflammation: A Case-Control Study

0

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류정신과학

초록

Objective Methamphetamine use disorder (MUD) is a global health condition that impairs a person’s health which may result in morbidity and mortality. Inflammation is a crucial process playing a vital role in MUD. For this reason, it is necessary to examine biochemical parameters for follow-up and treatment alternatives.Methods We aimed to reveal the relationship between inflammatory response and MUD by evaluating peripheral hemogram parameters, leukocyte count, subtypes, and their ratios to each other, systemic immune inflammation index (SII), monocyte/high-density lipoprotein (HDL) ratio, and human C-reactive protein (CRP) in adult men with MUD. We included 76 adult male participants in the patient group and 70 adult male participants in the control group. We calculated the neutrophil/lymphocyte rate (NLR), monocyte/lymphocyte rate (MLR), platelet/lymphocyte rate (PLR), and basophil/lymphocyte rate (BLR). In addition, we obtained the SII and the monocyte/HDL rate.Results The patients’ leukocyte (p<0.001), platelet (p<0.001), plateletcrit (PCT) (p=0.002), neutrophil (p<0.001), monocyte (p=0.002), CRP (p<0.001), NLR (p=0.001), PLR (p=0.004), MLR (p=0.009), SII (p<0.001) and monocyte/HDL ratio (p<0.001) were higher than the control group. We observed a significant and positive relationship between the daily methamphetamine intake, and methamphetamine use duration (p=0.002), PCT (p=0.044), neutrophil (p=0.021), NLR (p=0.001), PLR (p=0.004), MLR (p=0.029), and SII (p<0.001). Daily methamphetamine intake had a significant and positive effect on SII. A one-unit increase in daily methamphetamine intake elevated SII by 165.53 units.Conclusion The results confirm the presence of peripheral subclinical inflammation and systemic immune inflammation in adult men with MUD.

Abstract

Objective Methamphetamine use disorder (MUD) is a global health condition that impairs a person’s health which may result in morbidity and mortality. Inflammation is a crucial process playing a vital role in MUD. For this reason, it is necessary to examine biochemical parameters for follow-up and treatment alternatives.Methods We aimed to reveal the relationship between inflammatory response and MUD by evaluating peripheral hemogram parameters, leukocyte count, subtypes, and their ratios to each other, systemic immune inflammation index (SII), monocyte/high-density lipoprotein (HDL) ratio, and human C-reactive protein (CRP) in adult men with MUD. We included 76 adult male participants in the patient group and 70 adult male participants in the control group. We calculated the neutrophil/lymphocyte rate (NLR), monocyte/lymphocyte rate (MLR), platelet/lymphocyte rate (PLR), and basophil/lymphocyte rate (BLR). In addition, we obtained the SII and the monocyte/HDL rate.Results The patients’ leukocyte (p<0.001), platelet (p<0.001), plateletcrit (PCT) (p=0.002), neutrophil (p<0.001), monocyte (p=0.002), CRP (p<0.001), NLR (p=0.001), PLR (p=0.004), MLR (p=0.009), SII (p<0.001) and monocyte/HDL ratio (p<0.001) were higher than the control group. We observed a significant and positive relationship between the daily methamphetamine intake, and methamphetamine use duration (p=0.002), PCT (p=0.044), neutrophil (p=0.021), NLR (p=0.001), PLR (p=0.004), MLR (p=0.029), and SII (p<0.001). Daily methamphetamine intake had a significant and positive effect on SII. A one-unit increase in daily methamphetamine intake elevated SII by 165.53 units.Conclusion The results confirm the presence of peripheral subclinical inflammation and systemic immune inflammation in adult men with MUD.

참고문헌 (44)

  1. Köroğlu E, "Diagnostic and statistical manual of mental disorders", pp.231~290 (2013), Hekimler Yayın Birliği
  2. Moszczynska A, "Current and emerging treatments for methamphet amine use disorder", Curr Neuropharmacol, 19, pp.2077~2091 (2021)
  3. Yang X, "The main molecu lar mechanisms underlying methamphetamine-induced neurotoxicity and implications for pharmacological treatment", Front Mol Neurosci, 11, pp.186~ (2018)
  4. Huckans M, "Plasma in f lammatory factors are associated with anxiety, depression, and cogni tive problems in adults with and without methamphetamine depen dence : an exploratory protein array study", Front Psychiatry, 6, pp.178~ (2015)
  5. Salamanca SA, "Impact of methamphetamine on infection and immunity", Front Neurosci, 8, pp.445~ (2015)
  6. Peerzada H, "Methamphetamine administration modifies leukocyte proliferation and cytokine production in murine tissues", Immunobiology, 218, pp.10631068~ (2013)
  7. Debnath M, "Recent advances in psychoneuroimmunology : inflammation in psy chiatric disorders", Transl Neurosci, 2, pp.121~137 (2011)
  8. Morcuende A, "Inflam matory biomarkers in addictive disorders", Biomolecules, 11, pp.1824~ (2021)
  9. Kulu M, "Inflammation levels in patients with alco hol and substance use disorders", Cukurova Med J, 46, pp.1558~1565 (2021)
  10. Soder HE, "Elevated neutrophil to lymphocyte ratio in older adults with cocaine use disorder as a marker of chronic inflammation", Clin Psycho pharmacol Neurosci, 18, pp.32~40 (2020)
  11. Dadouli K, "Neutrophil-to-lymphocyte, monocyte-to-lympho cyte, platelet-to-lymphocyte ratio and systemic immune-inflammatory index in different states of bipolar disorder", Brain Sci, 12, pp.1034~ (2022)
  12. Citirik M, "MPV may reflect subcinical platelet activation in diabetic patients with and without diabetic retinopathy", Eye(Lond), 29, pp.376~379 (2015)
  13. Qian Y, "Association of platelet count and plateletcrit with nerve conduction function and peripheral neuropathy in patients with type 2 diabetes mellitus", J Diabe tesInvestig, 12, pp.1835~1844 (2021)
  14. Yang R, "Prognostic value of sys temic immune-inflammation index in cancer : a meta-analysis", J Can cer, 9, pp.3295~3302 (2018)
  15. Felger JC, "What does plasma CRP tell us about peripheral and cen tral inflammation in depression?", Mol Psychiatry, 25, pp.1301~1311 (2020)
  16. Efe TH, "The prognostic value of the monocyte", HDL ratio in predicting short term mortality in patients with acute pulmonary embolism, 2016, pp.19, 149~153
  17. Zhong JH, "Prognostic role of systemic immune inflammation index in solid tumors : a systematic review and meta analysis", Oncotarget, 8, pp.75381~75388 (2017)
  18. Cıcek E, "Increased neutrophil lymphocyte and platelet-lymphocyte ratios in male heroin addicts : a prospective controlled study", Clin Psychopharmacol Neurosci, 16, pp.190~196 (2018)
  19. Demir B, "Neutrophil-lym phocyte ratio and platelet-lymphocyte ratio in methamphetamine use disorder", Psychiatr Clin Psychopharmacol, 31, pp.34~39 (2021)
  20. Osório FL, "Clinical validity and intrarater and test-retest re liability of the structured clinical interview for DSM-5-clinician ver sion(SCID-5-CV)", Psychiatry Clin Neurosci, 73, pp.754~760 (2019)
  21. Elbir M, "Adaptation and reliability of the structured clinical interview for DSM 5-disorders - clinician version (SCID-5", CV) to the Turkish language, 2019, pp.30, 51~56
  22. Wallace C, "Methamphetamine use, dependence and treatment access in rural and regional North Coast of New South Wales, Australia", Drug Alcohol Rev, 28, pp.592~599 (2009)
  23. McKetin R, "Health service utilisation attributable to methamphetamine use in Australia : patterns, predictors and national impact", Drug Alcohol Rev, 37, pp.196~204 (2018)
  24. Paulus MP, "Neurobiology, clinical presentation, and treat ment of methamphetamine use disorder : a review", JAMA Psychiatry, 77, pp.959~966 (2020)
  25. Kilic E, "Evaluation of neutrophil to lymphocyte and platelet to lymphocyte ra tios in rheumatoid arthritis", Dicle Med J, 43, pp.241~247 (2016)
  26. Bulut NS, "The severity of inflammation in major neuropsychiatric disorders : comparison of neutrophil-lympho cyte and platelet-lymphocyte ratios between schizophrenia, bipolar ma nia, bipolar depression, major depressive disorder, and obsessive com pulsive disorder", Nord J Psychiatry, 75, pp.624~632 (2021)
  27. Nazari A, "Effect of meth amphetamine exposure on the plasma levels of endothelial-derived mi croparticles", Drug Alcohol Depend, 186, pp.219~225 (2018)
  28. Papageorgiou M, "Meth amphetamine and its immune-modulating effects", Maturitas, 121, pp.13~21 (2019)
  29. Buchanan JB, "A neurotoxic regimen of methamphetamine exacerbates the febrile and neuroinflammatory re sponse to a subsequent peripheral immune stimulus", J Neuroinflammation, 7, pp.82~ (2010)
  30. Kohno M, "Neuroinflammation in addiction : a review of neuroimaging stud ies and potential immunotherapies", Pharmacol Biochem Behav, 179, pp.34~42 (2019)
  31. Rajavashisth TB, "Decreased prevalence of diabetes in marijuana users : cross-sectional data from the national health and nutrition examination survey(NHANES)III", BMJ Open, 2, pp.e000494~ (2012)
  32. Nazir S, "Interaction between high-density lipoproteins and inflammation:function matters more than concentration!", Adv Drug Deliv Rev, 159, pp.94~119 (2020)
  33. Wei Y, "Investigation of systemic immune-inflammation index, neutrophil", high-density lipoprotein ratio, lymphocyte, high-density lipoprotein ratio as indicators of inflammation in patients with schizo phrenia and bipolar disorder, pp.Front Psychiatry, 2022[DOI]
  34. Li Y, "Elevated monocyte-to-HDL cho lesterol ratio predicts post-stroke depression", Front Psychiatry, 13, pp.902022~ (2022)
  35. Huang H, "Prognostic value of preoperative systemic immune-inflammation index in patients with cervical cancer", Sci Rep, 9, pp.3284~ (2019)
  36. Uyar B, "Effects of major depressive disorder on mono cytes, high-density lipoprotein(HDL)and monocyte to HDL ratio : a case-control study", Psychiatr Danub, 34, pp.687~694 (2022)
  37. Zhou L, "Inflammation and coronary heart disease risk in patients with depression in China mainland : a cross-sectional study", Neuropsychiatr Dis Treat, 16, pp.81~86 (2020)
  38. Wang J, "Peripheral inflammatory biomarkers of methamphetamine withdrawal patients based on the neuro-inflam mation hypothesis : the possible improvement effect of exercise", Front Psychiatry, 12, pp.795073~ (2021)
  39. Pogorzelska K, "Characteristics of platelet indices and their prognostic significance in selected medical condition-a systematic review", Adv Med Sci, 65, pp.310~315 (2020)
  40. Lappin JM, "Stroke and methamphetamine use in young adults : a review", J Neurol Neurosurg Psychiatry, 88, pp.10791091~ (2017)
  41. Schürer S, "Clinical characteristics, histopathological features, and clinical outcome of methamphetamine-associated cardiomyopathy", JACC Heart Fail, 5, pp.435~445 (2017)
  42. Ahearn OC, "Chemokines, cytokines and sub stance use disorders", Drug Alcohol Depend, 220, pp.108511~ (2021)
  43. Li MJ, "Ibudilast attenuates peripheral inflammatory effects of methamphetamine in patients with methamphetamine use disorder", Drug Alcohol Depend, 206, pp.107776~ (2020)
  44. Linker KE, "Glial mechanisms underlying sub stance use disorders", Eur J Neurosci, 50, pp.2574~2589 (2019)

관련 논문AI추천

Oxidative Stress and Inflammatory Biomarkers in People with Methamphetamine Use DisorderÇetin Turan, Güliz Şenormancı, Ömer Şenormancı, Özcan Erel, Salim Neşelioğlu, Yasemin Budak대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2023 · 제21권 제3호Increased Neutrophil-lymphocyte and Platelet-lymphocyte Ratios in Male Heroin Addicts: A Prospective Controlled StudyAslı Seda Kıraç, Başak Demırel, Erdinc Cıcek, Ibrahim Eren, Ismet Esra Cıcek대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2018 · 제16권 제2호Elevated Neutrophil to Lymphocyte Ratio in Older Adults with Cocaine Use Disorder as a Marker of Chronic InflammationAmber M. Berumen, Antonio L. Teixeira, Charles E. Green, Heather E. Soder, Jessica Vincent, Joy M. Schmitz, Kira E. Gomez, Margaret C. Wardle, Robert Suchting, Scott D. Lane대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2020 · 제18권 제1호Neutrophil-lymphocyte and Platelet-lymphocyte Ratios among Adolescents with Substance Use Disorder: A Preliminary StudyMehmet Akif Akıncı, Necati Uzun, Serdar Karatoprak, Yunus Emre Dönmez대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2021 · 제19권 제4호Association of Cognitive Impairment and Peripheral Inflammation in Methamphetamine-dependent Patients: A Cross-sectional Study on Neuroinflammatory Markers TNF-α and IL-6Chutikorn Nopparat, Doungjai Buntup, Jatuporn Namyen, Kannika Permpoonputtana, Parichart Boontem, Piyarat Govitrapong대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2025 · 제23권 제2호Evaluation of Oxidant/Antioxidant Status and Cytokine Levels in Patients with Cannabis Use DisorderErdinc Cicek, Huseyin Bayazit, Ibrahim Fatih Karababa, Nurten Aksoy, Salih Selek대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2017 · 제15권 제3호

이 간행물의 다른 논문 (12건)