본문 바로가기
KERD
논문KCI 등재

Decreased Serum Cocaine- and Amphetamine-Regulated Transcript Level in Internet Gaming Disorder

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류정신과학

초록

Objective Vulnerability to internet gaming disorder (IGD) has increased as internet gaming continues to grow. Cocaine- and amphetamine-regulated transcript (CART) is a hormone that plays a role in reward, anxiety, and stress. The purpose of this study was to identify the role of CART in the pathophysiology of IGD. Methods The serum CART levels were measured by enzyme-linked immunosorbent assay, and the associations of the serum CART level with psychological variables were analyzed in patients with IGD (n=31) and healthy controls (HC) (n=42). Results The serum CART level was significantly lower in the IGD than HC group. The IGD group scored significantly higher than the HC group on the psychological domains of depression, anxiety, the reward response in the Behavioral Activation System and Behavioral Inhibition System. There were no significant correlations between serum CART level and other psychological variables in the IGD group. Conclusion Our results indicate that a decrease in the expression of the serum CART level is associated with the vulnerability of developing IGD. This study supports the possibility that CART is a biomarker in the pathophysiology of IGD.

Abstract

Objective Vulnerability to internet gaming disorder (IGD) has increased as internet gaming continues to grow. Cocaine- and amphetamine-regulated transcript (CART) is a hormone that plays a role in reward, anxiety, and stress. The purpose of this study was to identify the role of CART in the pathophysiology of IGD. Methods The serum CART levels were measured by enzyme-linked immunosorbent assay, and the associations of the serum CART level with psychological variables were analyzed in patients with IGD (n=31) and healthy controls (HC) (n=42). Results The serum CART level was significantly lower in the IGD than HC group. The IGD group scored significantly higher than the HC group on the psychological domains of depression, anxiety, the reward response in the Behavioral Activation System and Behavioral Inhibition System. There were no significant correlations between serum CART level and other psychological variables in the IGD group. Conclusion Our results indicate that a decrease in the expression of the serum CART level is associated with the vulnerability of developing IGD. This study supports the possibility that CART is a biomarker in the pathophysiology of IGD.

참고문헌 (51)

  1. 2021 game user survey, "Korea Creative Content Agency", Korea Creative Content Agency, ~ (2021)
  2. King D, "Internet gaming disorder : theory, assessment, treatment, and prevention" (2018), Academic Press
  3. Wang HY, "The associations between gaming motivation and internet gaming disorder : systematic review and meta-analysis", JMIR Ment Health, 9, pp.e23700~ (2022)
  4. Luo T, "Diagnostic contribu tion of the DSM-5 criteria for internet gaming disorder", Front Psychiatry, 12, pp.777397~ (2022)
  5. Kuss DJ, "Internet gaming addiction : current perspectives", Psychol Res Behav Manag, 6, pp.125~137 (2013)
  6. Dong G, "Reward", punishment sensitivities among internet addicts : implications for their addictive behaviors, 2013, pp.46, 139~145
  7. Zhu Y, "Molecular and functional imaging of inter net addiction", Biomed Res Int, 2015, pp.378675~ (2015)
  8. Meng Y, "The prefrontal dysfunction in individuals with internet gaming disorder : a meta-analysis of functional magnetic resonance imaging studies", Addict Biol, 20, pp.799~808 (2015)
  9. Zhang Y, "Cue-in duced behavioral and neural changes among excessive internet gamers and possible application of cue exposure therapy to internet gaming disorder", Front Psychol, 7, pp.675~ (2016)
  10. Kim YJ, "The cognitive dysregulation of internet ad diction and its neurobiological correlates", Front Biosci(Elite Ed), 9, pp.307~320 (2017)
  11. Douglass J, "Characterization of the human cDNA and ge nomic DNA encoding CART : a cocaine-and amphetamine-regulated transcript", Gene, 169, pp.241~245 (1996)
  12. Kristensen P, "Hypothalamic CART is a new anorectic peptide regulated by leptin", Nature, 393, pp.72~76 (1998)
  13. Zhang M, "Roles of cocaine-and amphetamine-regulated transcript in the central nervous system", Clin Exp Pharmacol Physiol, 39, pp.586~592 (2012)
  14. Kuhar MJ, "CART pep tides", Neuropeptides, 36, pp.1~8 (2002)
  15. Dandekar MP, "Importance of cocaine-and amphetamine-regulated transcript peptide in the central nucleus of amygdala in anxiogenic responses in duced by ethanol withdrawal", Neuropsychopharmacology, 33, pp.1127~1136 (2008)
  16. Couceyro PR, "Cocaine-and amphetamine-regulated transcript(CART)pep tides modulate the locomotor and motivational properties of psycho stimulants", J Pharmacol Exp Ther, 315, pp.1091~1100 (2005)
  17. Kuhar MJ, "Co caine-and amphetamine-regulated transcript peptides play a role in drug abuse and are potential therapeutic targets", AAPS J, 7, pp.E259~ (2005)
  18. Yu C, "A new insight into the role of CART in cocaine reward : involvement of CaMKII and inhibitory G protein coupled receptor signaling", Front Cell Neurosci, 11, pp.244~ (2017)
  19. Dandekar MP, "Cocaine-and amphetamine-regulated transcript peptide plays a role in the manifes tation of depression : social isolation and olfactory bulbectomy models reveal unifying principles", Neuropsychopharmacology, 34, pp.12881300~ (2009)
  20. Nakhate KT, "Central regulation of feeding behavior during social isolation of rat : evidence for the role of endogenous CART system", Int J Obes(Lond), 35, pp.773~784 (2011)
  21. Upadhya MA, "CART peptide in the nucleus accumbens shell acts downstream to dopamine and mediates the reward and reinforcement actions of morphine", Neuropharmacology, 62, pp.1823~1833 (2012)
  22. Rogge G, "CART peptides : reg ulators of body weight, reward and other functions", Nat Rev Neurosci, 9, pp.747~758 (2008)
  23. Achab S, "Mas sively multiplayer online role-playing games : comparing characteristics of addict vs non-addict online recruited gamers in a French adult pop ulation", BMC Psychiatry, 11, pp.144~ (2011)
  24. Dong G, "A cognitive-behavioral model of internet gam ing disorder : theoretical underpinnings and clinical implications", J Psy chiatr Res, 58, pp.7~11 (2014)
  25. Peltzer K, "Heavy internet use and its associa tions with health risk and health-promoting behaviours among Thai university students", Int J Adolesc Med Health, 26, pp.187~194 (2014)
  26. Spada MM, "An overview of problematic internet use", Addict Behav, 39, pp.3~6 (2014)
  27. Whang LS, "Internet over-users’ psychological profiles : a behavior sampling analysis on internet addiction", Cyberpsychol Be hav, 6, pp.143~150 (2003)
  28. Lim JA, "Changes of quality of life and cognitive function in individuals with internet gam ing disorder: a 6-month follow-up", Medicine (Baltimore), 95, pp.e5695~ (2016)
  29. Younes F, "In ternet addiction and relationships with insomnia, anxiety, depression, stress and self-esteem in university students : a cross-sectional designed study", PLoS One, 11, pp.e0161126~ (2016)
  30. Rachubińska K, "The relationship between loneliness, depression, internet and social media addiction among young Polish women", Eur Rev Med Pharmacol Sci, 25, pp.1982~1989 (2021)
  31. Teng Z, "Depression and anx iety symptoms associated with internet gaming disorder before and during the COVID-19 pandemic : a longitudinal study", J Behav Addict, 10, pp.169~180 (2021)
  32. Choi JS, "Dysfunctional inhibitory control and impulsivity in internet addiction", Psychiatry Res, 215, pp.424~428 (2014)
  33. D’Hondt F, "Electrophysiological correlates of prob lematic internet use : critical review and perspectives for future research", Neurosci Biobehav Rev, 59, pp.64~82 (2015)
  34. Young KS, "Caught in the net: how to recognize the signs of internet addiction—and a winning strategy for recovery" (1998), John Wiley & Sons
  35. Hwang ST, "Korean Wechsler adult intelligence scale-IV" (2012), Korea Psychology Co
  36. Park M, "Dysfunc tional information processing during an auditory event-related poten tial task in individuals with internet gaming disorder", Transl Psychiatry, 6, pp.e721~ (2016)
  37. Park M, "Neurophysi ological and cognitive correlates of error processing deficits in internet gaming disorder", Cereb Cortex, 30, pp.4914~4921 (2020)
  38. Beck AT, "Manual for the Beck Depression Inven tory-II" (1996), Psychological Corporation
  39. Kim MS, "The validation study I of Korean BDI-II: in female university students sample", Kor J Clin Psychol, 26, pp.997~1014 (2007)
  40. Beck AT, "An inventory for measuring clinical anxiety : psychometric properties", J Consult Clin Psychol, 56, pp.893~897 (1988)
  41. Yook SP, "A clinical study on the Korean version of Beck Anxi ety Inventory: comparative study of patient and non-patient", Kor J Clin Psychol, 16, pp.185~197 (1997)
  42. Carver CS, "Behavioral inhibition, behavioral activation, and affective responses to impending reward and punishment : the BIS", BAS scales, 1994, pp.67, 319~333
  43. Gray JA, "Brain systems that mediate both emotion and cognition", Cogn Emot, 4, pp.269~288 (1990)
  44. Wiehager S, "Increased levels of cocaine and amphetamine regulated transcript in two animal models of depression and anxiety", Neurobiol Dis, 34, pp.375~380 (2009)
  45. Erdle S, "The general factor of personality, BIS–BAS, expec tancies of reward and punishment, self-esteem, and positive and nega tive affect", Pers Individ Differ, 48, pp.762~766 (2010)
  46. Newman JP, "Validating a distinc tion between primary and secondary psychopathy with measures of Gray’s BIS and BAS constructs", J Abnorm Psychol, 114, pp.319~323 (2005)
  47. McFarland BR, "Be havioral activation system deficits predict the six-month course of de pression", J Affect Disord, 91, pp.229~234 (2006)
  48. Alloy LB, "Behavioral approach system and behavioral inhibition system sensitivities and bipolar spectrum disorders : prospective prediction of bipolar mood episodes", Bipolar Disord, 10, pp.310~322 (2008)
  49. Yen JY, "The association between harmful alcohol use and internet addiction among college students : comparison of personality", Psychiatry Clin Neurosci, 63, pp.218~224 (2009)
  50. Kim DY, "Effects of the BAS and BIS on decision-making in a gambling task", Pers Individ Differ, 50, pp.1131~1135 (2011)
  51. Ahmadian-Moghadam H, "Co caine-and amphetamine-regulated transcript(CART) : a multifaceted neuropeptide", Peptides, 110, pp.56~77 (2018)

관련 논문AI추천

Serum Cocaine- and Amphetamine-Regulated Transcript Levels and Cooperativeness in Adolescents With Internet Gaming DisorderArom Pyeon, Dai-Jin Kim, Dong Huey Cheon, Heejin Lee, Hong Choi, Hyunho Lee, Ji Eun Lee, Ji Hyun Back, Ji-Won Chun, Jung-Seok Choi, Yae Eun Park대한신경정신의학회 · PSYCHIATRY INVESTIGATION2025 · 제22권 제12호Altered Plasma Levels of Glial Cell Line-Derived Neurotrophic Factor in Patients with Internet Gaming Disorder: A Case-Control, Pilot Study최미란, Dai-Jin Kim, Hyun Cho, Jo-Eun Jeong, Jung-Seok Choi, Sam-Wook Choi, Soo-Hyun Paik대한신경정신의학회 · PSYCHIATRY INVESTIGATION2019 · 제16권 제6호Decreased Serum Glutamate Levels in Male Adults with Internet Gaming Disorder: A Pilot Study최미란, Dai Jin Kim, Sol Hee Bang, Soo-Hyun Paik, Su Min Kwak대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2018 · 제16권 제3호A Literature Review on the Efficacy and Related Neural Effects of Pharmacological and Psychosocial Treatments in Individuals With Internet Gaming DisorderKim Seung-Gon, Lee Sang-Kyu, Park Seon-Cheol, Seo Eun Hyun, Yang Hae-Jung, Yoon Hyung-Jun대한신경정신의학회 · PSYCHIATRY INVESTIGATION2021 · 제18권 제12호인터넷 게임 장애의 포괄적 진단 평가 : 임상적 및 신경생물학적 평가조현, 김대진, 백수현, 최삼욱, 최정석대한신경정신의학회 · 신경정신의학2016 · 제55권 제4호The Hierarchical Implications of Internet Gaming Disorder Criteria: Which Indicate more Severe Pathology?권용실, 김민섭, 김은진, 방수영, 백경영, 이승엽, 이해국, 임현우, 정현석, 조선진, 최정석대한신경정신의학회 · PSYCHIATRY INVESTIGATION2017 · 제14권 제3호

이 간행물의 다른 논문 (12건)