A Pediatric Case of Inflammatory Bowel Disease with Renal Amyloidosis
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초록
Amyloidosis is a rare disease that results from the deposition of extracellular protein in various body tissues, causing progressive organ dysfunction. Secondary renal amyloidosis is a rare but serious complication of chronic inflammatory bowel disease, particularly in patients with Crohn’s disease or ulcerative colitis. We report a case of secondary renal amyloidosis in a pediatric patient who reported a 16- year history of “very early onset inflammatory bowel disease”. Intensive treatment including repeated infliximab infusions improved clinical parameters of inflammatory bowel disease, although renal dysfunction showed progression. Amyloidosis should be considered in patients with IBD, particularly if they suffered disease progression.
Abstract
Amyloidosis is a rare disease that results from the deposition of extracellular protein in various body tissues, causing progressive organ dysfunction. Secondary renal amyloidosis is a rare but serious complication of chronic inflammatory bowel disease, particularly in patients with Crohn’s disease or ulcerative colitis. We report a case of secondary renal amyloidosis in a pediatric patient who reported a 16- year history of “very early onset inflammatory bowel disease”. Intensive treatment including repeated infliximab infusions improved clinical parameters of inflammatory bowel disease, although renal dysfunction showed progression. Amyloidosis should be considered in patients with IBD, particularly if they suffered disease progression.
참고문헌 (18)
- Falk RH, "The systemic amyloidoses", N Engl J Med, 337, pp.898~909 (1997)[DOI]
- Perfetto F, "Systemic amyloidosis: a challenge for the rheumatologist", Nat Rev Rheumatol, 6, pp.417~429 (2010)[DOI]
- Uhlig HH, "The diagnostic approach to monogenic very early onset inflammatory bowel disease", Gastroenterology, 147, pp.990~1007 (2014)[DOI]
- Greenstein AJ, "Amyloidosis and inflammatory bowel disease. A 50-year experience with 25 patients", Medicine (Baltimore), 71, pp.261~270 (1992)[DOI]
- Dember LM, "Amyloidosis-Associated Kidney Disease", J Am Soc Nephrol, 17, pp.3458~3471 (2006)[DOI]
- Merlini G, "Molecular mechanisms of amyloidosis", N Engl J Med, 349, pp.583~596 (2003)[DOI]
- Blum W, "Primary amyloidosis patients with significant organ dysfunction tolerate autologous transplantation after conditioning with single-dose total body irradiation alone: A feasibility study", Biol Blood Marrow Transplant, 9, pp.397~404 (2003)[DOI]
- Wester AL, "Secondary amyloidosis in inflammatory bowel disease: a study of 18 patients admitted to Rikshospitalet University Hospital, Oslo, from 1962 to 1998", Inflamm Bowel Dis, 7, pp.295~300 (2001)[DOI]
- Bilginer Y, "Renal amyloidosis in children", Pediatr Nephrol, 26, pp.1215~1227 (2011)[DOI]
- Noh SY, "Fifteen-yearold colon cancer patient with a 10-year history of ulcerative colitis", World J Gastroenterol, 19, pp.2437~2440 (2013)[DOI]
- Levine A, "Pediatric modification of the Montreal classification for inflammatory bowel disease: the Paris classification", Inflamm Bowel Dis, 17, pp.1314~1321 (2011)[DOI]
- Muise AM, "The age of gene discovery in very early onset inflammatory bowel disease", Gastroenterology, 143, pp.285~288 (2012)[DOI]
- Dotson JL, "Extraintestinal manifestations of pediatric inflammatory bowel disease and their relation to disease type and severity", J Pediatr Gastroenterol Nutr, 51, pp.140~145 (2010)[DOI]
- Corica D, "Renal Involvement in inflammatory bowel diseases", J Crohns Colitis, 10, pp.226~235 (2016)[DOI]
- Sayed RH, "Misdiagnosing renal amyloidosis as minimal change disease", Nephrol Dial Transplant, 29, pp.2120~2126 (2014)[DOI]
- Lachmann HJ, "Natural history and outcome in systemic AA amyloidosis", N Engl J Med, 23, pp.2361~2371 (2007)
- Cabezuelo JB, "Infliximab, AA amyloidosis and Crohn's disease", Nefrologia, 32, pp.385~388 (2012)
- Osamu Saitoh, "Renal amyloidosis as a late complication of Crohn's disease: a case report and review of the literature from Japan", World J Gastroentero, 6, pp.461~464 (2000)[DOI]