Interaction Effect of Childhood Abuse History and Suicidality on 12-Month Antidepressant Response in Patients With Depressive Disorder
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Objective We aimed to identify the individual and interactive effects of childhood abuse and suicidal ideation on antidepressant treatment response in 12 months.Methods In this prospective research, 1,262 depressive patients were asked about their childhood abuse history, suicidal ideation, and other clinical characteristics and socio-demographic features at baseline, and 1,015 of them were followed during 1 year of stepwise pharmacotherapy. The individual and interactive relationships of the childhood abuse history and suicidal ideation on 12-month antidepressant non-remission were explored by logistic regression with relevant covariates.Results Having a childhood abuse history and higher suicidal ideation significantly predicted a non-remission state in 12 months respectively. The interaction term of childhood abuse and suicidal ideation was also significantly related to a non-remission state at 12 months. To be specific, in the low suicidal ideation group, depressive patients with a childhood abuse history were more likely to be in a non-remission state after 12 months of medication. In the high suicidal ideation group, however, childhood abuse history was not significantly associated with the non-remission state at 12 months.Conclusion The childhood abuse history and the level of suicidal ideation are informative factors predicting the long-term results of antidepressant treatment, especially when they are combined. Clinicians may consider antidepressants with a higher affinity for patients with childhood abuse history even if they don’t have suicidal ideation. The cognitive intervention for suicidal ideation might be helpful in addition to pharmacological treatment.
Abstract
Objective We aimed to identify the individual and interactive effects of childhood abuse and suicidal ideation on antidepressant treatment response in 12 months.Methods In this prospective research, 1,262 depressive patients were asked about their childhood abuse history, suicidal ideation, and other clinical characteristics and socio-demographic features at baseline, and 1,015 of them were followed during 1 year of stepwise pharmacotherapy. The individual and interactive relationships of the childhood abuse history and suicidal ideation on 12-month antidepressant non-remission were explored by logistic regression with relevant covariates.Results Having a childhood abuse history and higher suicidal ideation significantly predicted a non-remission state in 12 months respectively. The interaction term of childhood abuse and suicidal ideation was also significantly related to a non-remission state at 12 months. To be specific, in the low suicidal ideation group, depressive patients with a childhood abuse history were more likely to be in a non-remission state after 12 months of medication. In the high suicidal ideation group, however, childhood abuse history was not significantly associated with the non-remission state at 12 months.Conclusion The childhood abuse history and the level of suicidal ideation are informative factors predicting the long-term results of antidepressant treatment, especially when they are combined. Clinicians may consider antidepressants with a higher affinity for patients with childhood abuse history even if they don’t have suicidal ideation. The cognitive intervention for suicidal ideation might be helpful in addition to pharmacological treatment.
참고문헌 (33)
- Trivedi MH, "Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D : implications for clinical practice", Am J Psychiatry, 163, pp.28~40 (2006)
- Nelson J, "Childhood maltreat ment and characteristics of adult depression : meta-analysis", Br J Psychiatry, 210, pp.96~104 (2017)
- Williams LM, "Childhood trauma predicts antidepressant response in adults with major depression : data from the randomized international study to pre dict optimized treatment for depression", Transl Psychiatry, 6, pp.e799~ (2016)
- Nobile B, "Char acteristics and treatment outcome of suicidal depression : two large nat uralistic cohorts of depressed outpatients", Aust N Z J Psychiatry, 56, pp.347~364 (2022)
- Pompili M, "Response to intravenous antidepressant treatment by suicidal vs. nonsuicidal depressed patients", J Affect Disord, 122, pp.154~158 (2010)
- Perroud N, "History of suicide attempts among patients with depression in the GENDEP project", J Affect Disord, 123, pp.131~137 (2010)
- Szanto K, "Treatment outcome in suicidal vs. non-suicidal elderly patients", Am J Geriatr Psychiatry, 9, pp.261~268 (2001)
- Courtney DB, "Predictors, moderators, and mediators associat ed with treatment outcome in randomized clinical trials among ado lescents with depression : a scoping review", JAMA Netw Open, 5, pp.e2146331~ (2022)
- Wang W, "The interac tion effects of suicidal ideation and childhood abuse on brain structure and function in major depressive disorder patients", Neural Plast, 2021, pp.7088856~ (2021)
- Kang HJ, "The MAKE biomarker discovery for enhancing anTidepressant treatment effect and response(MAKE BETTER)study : design and methodolo gy", Psychiatry Investig, 15, pp.538~545 (2018)
- Sheehan DV, "The mini-international neuropsychiatric interview(M. I. N. I. ) : the development and validation of a structured diagnostic psychiatric in terview for DSM-IV and ICD-10", J Clin Psychiatry, 59(Suppl 20), pp.22~33 (1998)
- American Psychiatric Association, "Diagnostic and statistical manual of mental disorders" (1994), American Psychiatric As sociation
- Hamilton M, "A rating scale for depression", J Neurol Neurosurg Psychiatry, 23, pp.56~62 (1960)
- Bijl RV, "The Neth erlands mental health survey and incidence study(NEMESIS) : objec tives and design", Soc Psychiatry Psychiatr Epidemiol, 33, pp.581~586 (1998)
- Overall JE, "The brief psychiatric rating scale", Psychol Rep, 10, pp.799~812 (1962)
- Zigmond AS, "The hospital anxiety and depression scale", Acta Psychiatr Scand, 67, pp.361~370 (1983)
- Rabin R, "EQ-5D : a measure of health status from the Eu roQol group", Ann Med, 33, pp.337~343 (2001)
- Morosini PL, "Development, reliability and acceptability of a new version of the DSM-IV social and occupational functioning assessment scale(SOFAS)to assess routine social functioning", Acta Psychiatr Scand, 101, pp.323~329 (2000)
- Sarason IG, "Assessing the impact of life chang es: development of the life experiences survey", J Consult Clin Psychol
- Cohen S, "A global measure of perceived stress", J Health Soc Behav, 24, pp.385~396 (1983)
- Connor KM, "Development of a new resilience scale : the Connor-Davidson resilience scale(CD-RISC)", Depress Anxiety, 18, pp.76~82 (2003)
- Zimet GD, "The multidimensional scale of perceived social support", J Pers Assess, 52, pp.30~41 (1988)
- Lee BO, "Development of Korean version of alcohol use disorders identification test(AUDIT-K) : its reliability and validity", J Korean Acad Addict Psychiatry, 4, pp.8392~ (2000)
- Malhi GS, "Royal Australian and New Zealand college of psychiatrists clinical prac tice guidelines for mood disorders", Aust N Z J Psychiatry, 49, pp.10871206~ (2015)
- Kim JM, "Short and long-term treatment outcomes of stepwise psychopharmacotherapy based on early clinical decision in patients with depressive disorders", J Affect Disord, 274, pp.315~325 (2020)
- Scheuer S, "Childhood abuse and depression in adulthood : the mediating role of allostatic load", Psychoneuroendocrinology, 94, pp.134~142 (2018)
- Hough CM, "Pre-treatment allostatic load and metabolic dysregulation pre dict SSRI response in major depressive disorder : a preliminary report", Psychol Med, 51, pp.2117~2125 (2021)
- Hammen C, "Depression and sensitization to stressors among young women as a function of childhood adversity", J Consult Clin Psychol, 68, pp.782~787 (2000)
- Lopez-Castroman J, "Suicidal de pressed patients respond less well to antidepressants in the short term", Depress Anxiety, 33, pp.483~494 (2016)
- Chu C, "The interpersonal theory of suicide : a systematic review and meta-analysis of a decade of cross-national research", Psychol Bull, 143, pp.1313~1345 (2017)
- Quilty LC, "Childhood abuse history in depression predicts better response to an tidepressants with higher serotonin transporter affinity : a pilot investi gation", Neuropsychobiology, 74, pp.78~83 (2016)
- Kothgassner OD, "Efficacy of dialectical behavior therapy for adolescent selfharm and suicidal ideation : a systematic review and meta-analysis", Psychol Med, 51, pp.1057~1067 (2021)
- Kennedy SH, "Canadian network for mood and anxiety treatments(CANMAT)2016clinical guidelines for the management of adults with major depressive disorder : section 3. Pharmacological treatments", Can J Psychiatry, 61, pp.540~560 (2016)