본문 바로가기
KERD
논문KCI 등재

Childhood Sexual Abuse and Cortical Thinning in Adults With Major Depressive Disorder

1

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류정신과학

초록

Objective A growing body of evidence reports on the effect of different types of childhood abuse on the structural and functional architecture of the brain. In the present study, we aimed to investigate the differences in cortical thickness according to specific types of childhood abuse between patients with major depressive disorder (MDD) and healthy controls (HCs).Methods A total of 61 patients with MDD and 98 HCs were included in this study. All participants underwent T1-weighted magnetic resonance imaging, and the occurrence of childhood abuse was assessed using the Childhood Trauma Questionnaire. We investigated the association between whole-brain cortical thickness and exposure to any type of childhood abuse and specific type of childhood abuse in the total sample using the FreeSurfer software.Results No significant difference was reported in the cortical thickness between the MDD and HC groups nor between the “any abuse” and “no abuse” groups. Compared to no exposure to childhood sexual abuse (CSA), exposure to CSA was significantly associated with cortical thinning in the left rostral middle frontal gyrus (p=0.00020), left (p=0.00240), right fusiform gyri (p=0.00599), and right supramarginal gyrus (p=0.00679).Conclusion Exposure to CSA may lead to cortical thinning of the dorsolateral prefrontal cortex, which is deeply involved in emotion regulation, to a greater extent than other types of childhood abuse.

Abstract

Objective A growing body of evidence reports on the effect of different types of childhood abuse on the structural and functional architecture of the brain. In the present study, we aimed to investigate the differences in cortical thickness according to specific types of childhood abuse between patients with major depressive disorder (MDD) and healthy controls (HCs).Methods A total of 61 patients with MDD and 98 HCs were included in this study. All participants underwent T1-weighted magnetic resonance imaging, and the occurrence of childhood abuse was assessed using the Childhood Trauma Questionnaire. We investigated the association between whole-brain cortical thickness and exposure to any type of childhood abuse and specific type of childhood abuse in the total sample using the FreeSurfer software.Results No significant difference was reported in the cortical thickness between the MDD and HC groups nor between the “any abuse” and “no abuse” groups. Compared to no exposure to childhood sexual abuse (CSA), exposure to CSA was significantly associated with cortical thinning in the left rostral middle frontal gyrus (p=0.00020), left (p=0.00240), right fusiform gyri (p=0.00599), and right supramarginal gyrus (p=0.00679).Conclusion Exposure to CSA may lead to cortical thinning of the dorsolateral prefrontal cortex, which is deeply involved in emotion regulation, to a greater extent than other types of childhood abuse.

참고문헌 (40)

  1. Bernstein DP, "Childhood trauma questionnaire : a retrospective self-report manual" (1998), The Psychological Corporation
  2. Abbasi MA, "Child maltreatment in the worldwide : a review article", Int J Pediatr, 3, pp.353~365 (2015)
  3. Nelson J, "Childhood maltreatment and characteristics of adult depression : meta-analysis", Br J Psychiatry, 210, pp.96~104 (2017)
  4. Humphreys KL, "Child maltreatment and depression : a meta-analysis of studies using the Childhood Trauma Questionnaire", Child Abuse Negl, 102, pp.104361~ (2020)
  5. McEwen BS, "Effects of adverse experiences for brain structure and function", Biol Psychiatry, 48, pp.721~731 (2000)
  6. Gold AL, "Childhood abuse and reduced cortical thickness in brain regions involved in emotional processing", J Child Psychol Psychiatry, 57, pp.1154~1164 (2016)
  7. Everaerd D, "Childhood abuse and deprivation are associated with distinct sex-dependent differences in brain morphology", Neuropsychopharmacology, 41, pp.1716~1723 (2016)
  8. Lim L, "Grey matter volume and thickness abnormalities in young people with a history of childhood abuse", Psychol Med, 48, pp.1034~1046 (2018)
  9. Tozzi L, "Interactive impact of childhood maltreatment, depression, and age on cortical brain structure : mega-analytic findings from a large multi-site cohort", Psychol Med, 50, pp.1020~1031 (2020)
  10. Cross D, "Neurobiological development in the context of childhood trauma", Clin Psychol(New York), 24, pp.111~124 (2017)
  11. McKlveen JM, "Role of prefrontal cortex glucocorticoid receptors in stress and emotion", Biol Psychiatry, 74, pp.672~679 (2013)
  12. Tomoda A, "Childhood sexual abuse is associated with reduced gray matter volume in visual cortex of young women", Biol Psychiatry, 66, pp.642~648 (2009)
  13. Blair KS, "Association of different types of childhood maltreatment with emotional responding and response control among youths", JAMA Netw Open, 2, pp.e194604~ (2019)
  14. Bernstein DP, "Validity of the Childhood Trauma Questionnaire in an adolescent psychiatric population", J Am Acad Child Adolesc Psychiatry, 36, pp.340~348 (1997)
  15. Andersen SL, "Preliminary evidence for sensitive periods in the effect of childhood sexual abuse on regional brain development", J Neuropsychiatry Clin Neurosci, 20, pp.292~301 (2008)
  16. Rinne-Albers MA, "Anterior cingulate cortex grey matter volume abnormalities in adolescents with PTSD after childhood sexual abuse", Eur Neuropsychopharmacol, 27, pp.1163~1171 (2017)
  17. First MB, "SCID-5-CV: structured clinical interview for DSM-5 disorders: clinician version" (2016), American Psychiatric Association Publishing
  18. Han KM, "Serum FAM19A5levels : a novel biomarker for neuroinflammation and neurodegeneration in major depressive disorder", Brain Behav Immun, 87, pp.852~859 (2020)
  19. Han KM, "A study combining whole-exome sequencing and structural neuroimaging analysis for major depressive disorder", J Affect Disord, 262, pp.31~39 (2020)
  20. Hamilton M, "A rating scale for depression", J Neurol Neurosurg Psychiatry, 23, pp.56~62 (1960)
  21. Oldfield RC, "The assessment and analysis of handedness : the Edinburgh inventory", Neuropsychologia, 9, pp.97~113 (1971)
  22. "Childhood trauma questionnaire (1994)"[URL]
  23. Fischl B, "Measuring the thickness of the human cerebral cortex from magnetic resonance images", Proc Natl Acad Sci U S A, 97, pp.11050~11055 (2000)
  24. Fischl B, "Automated manifold surgery : constructing geometrically accurate and topologically correct models of the human cerebral cortex", IEEE Trans Med Imaging, 20, pp.70~80 (2001)
  25. Fischl B, "Whole brain segmentation : automated labeling of neuroanatomical structures in the human brain", Neuron, 33, pp.341~355 (2002)
  26. Fischl B, "Cortical surface-based analysis. II : inflation, flattening, and a surface-based coordinate system", Neuroimage, 9, pp.195~207 (1999)
  27. Fischl B, "Automatically parcellating the human cerebral cortex", Cereb Cortex, 14, pp.11~22 (2004)
  28. Ségonne F, "Geometrically accurate topology-correction of cortical surfaces using nonseparating loops", IEEE Trans Med Imaging, 26, pp.518~529 (2007)
  29. Han KM, "Cortical thickness, cortical and subcortical volume, and white matter integrity in patients with their first episode of major depression", J Affect Disord, 155, pp.42~48 (2014)
  30. Na KS, "Brain-derived neurotrophic factor promoter methylation and cortical thickness in recurrent major depressive disorder", Sci Rep, 6, pp.21089~ (2016)
  31. Greve DN, "False positive rates in surface-based anatomical analysis", Neuroimage, 171, pp.6~14 (2018)
  32. Ochsner KN, "Functional imaging studies of emotion regulation : a synthetic review and evolving model of the cognitive control of emotion", Ann N Y Acad Sci, 1251, pp.E1~E24 (2012)
  33. Williams LM, "Precision psychiatry : a neural circuit taxonomy for depression and anxiety", Lancet Psychiatry, 3, pp.472~480 (2016)
  34. Li BJ, "A brain network model for depression : from symptom understanding to disease intervention", CNS Neurosci Ther, 24, pp.1004~1019 (2018)
  35. Carballedo A, "Early life adversity is associated with brain changes in subjects at family risk for depression", World J Biol Psychiatry, 13, pp.569~578 (2012)
  36. Edmiston EE, "Corticostriatal-limbic gray matter morphology in adolescents with self-reported exposure to childhood maltreatment", Arch Pediatr Adolesc Med, 165, pp.1069~1077 (2011)
  37. Schmaal L, "Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group", Mol Psychiatry, 22, pp.900~909 (2017)
  38. Kelly PA, "Cortical thickness, surface area, and gyrification abnormalities in children exposed to maltreatment : neural markers of vulnerability?", Biol Psychiatry, 74, pp.845~852 (2013)
  39. Teicher MH, "Annual research review : enduring neurobiological effects of childhood abuse and neglect", J Child Psychol Psychiatry, 57, pp.241~266 (2016)
  40. Hardt J, "Validity of adult retrospective reports of adverse childhood experiences : review of the evidence", J Child Psychol Psychiatry, 45, pp.260~273 (2004)

관련 논문AI추천

Cortical Volumetric Correlates of Childhood Trauma, Anxiety, and Impulsivity in Bipolar DisorderChon Myong-Wuk, Lee Dong-Kyun, Lee Hyeongrae, Lee Jung Hyun, Lee Wonhye, Park Dong Yeon, Ryu Vin, Song Hyehyun, Yu Rina대한신경정신의학회 · PSYCHIATRY INVESTIGATION2020 · 제17권 제7호Alterations in the Occipital Cortex of Drug-Naïve Adults With Major Depressive Disorder: A Surface-Based Analysis of Surface Area and Cortical Thickness김아람, 태우석, Ham Byung-Joo, Han Kyu-Man, Kang Wooyoung, Kang Youbin, Lee Jee Soo대한신경정신의학회 · PSYCHIATRY INVESTIGATION2021 · 제18권 제10호Regional Gray Matter Volume Reduction Associated with Major Depressive Disorder: A Voxel-Based Morphometry태우석대한자기공명의과학회 · Investigative Magnetic Resonance Imaging2015 · 제19권 제1호Cortical Thickness and Surface Area Abnormalities in Bipolar I and II Disorders김아람, Ham Byung-Joo, Han Kyu-Man, Kang Wooyoung, Kang Youbin, Tae Woo-Suk, Woo Yoonmi대한신경정신의학회 · PSYCHIATRY INVESTIGATION2021 · 제18권 제9호Electrophysiological Changes Related to Childhood Trauma in Patients with Major Depressive Disorder: An Event-related Potential Study심세훈, 이호성, Heejung Yoon, Hwa-Young Lee, In Soo Heo, Ji Sun Kim, Young Joon Kwon대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2022 · 제20권 제1호How Childhood Maltreatment Is Related to Suicidality, Bipolarity and Central Serotonergic Activity in Patients with Major Depressive Disorder: A Cross-Sectional Pilot StudyBun-Hee Lee, Young-Min Park대한신경정신의학회 · PSYCHIATRY INVESTIGATION2016 · 제13권 제2호

이 간행물의 다른 논문 (11건)