자발적인 휠 달리기 운동이 자연발생고혈압쥐의 대동맥 두께 및 맥파전파속도에 미치는 영향
The Effect of voluntary wheel running on aorta thickness and pulse wave velocity in spontaneously hypertensive rats.
3
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
본 연구의 목적은 자발적인 휠 달리기 운동이 자연발생고혈압쥐의 대동맥 두께 및 대동맥 맥파전파속도에 미치는 영향을 살펴보는데 있다. 자연발생고혈압쥐 및 위스타 계열의 쥐가 실험군 및 통제군으로 사용되었으며, 자연발생고혈압쥐는 암, 수로 각각 나누었다. 자연발생고혈압쥐는 6주령에 각각 운동군과 비운동군으로 나누었으며, 운동군 케이지에는 회전 휠을 설치하여 쥐가 자발적인 운동이 가능하도록 하였다. 실험 시작 후 24주 후 대동맥 두께와 맥파전파속도를 측정하였으며, 결과는 다음과 같다. 자연발생고혈압쥐 숫컷은 운동군에서 비운동군에 비해 체중이 낮았으나, 암컷은 운동군이 비운동군에 비해 오히려 높았다. 사료섭취량은 암, 수 모두 운동군이 비운동군에 비해 높았다. 암컷 운동군은 숫컷 운동군에 비해 더 많은 활동량을 보였다. 간접적 tail-cuff 방식으로 측정된 수축기 혈압은 SHR 운동군과 비운동군 사이에 지속적인 차이가 발견되지 않았다. SHR의 대동맥 맥파전파속도는 운동군이 비운동군에 비해 유의하게 낮았으나, SHR 암컷에서는 운동군과 비운동군 사이에 유의한 차이가 나타나지 않았다. 중막 두께 비율은 암, 수 모두 운동군이 비운동군에 비해 유의하게 낮았다. 이러한 결과를 종합해 볼 때 자발적인 휠 달리기 운동이 숫컷 SHR의 대동맥 탄성을 증가시키는데 효과적인 것으로 나타났다.
Abstract
The purpose of present study was to investigate the effect of the voluntary wheel running on aorta thickness and pulse wave velocity in spontaneously hypertensive rats(SHR). SHR and Wistar control rats(WCR) of both sexes were used in this study. Male an female SHR were respectively divided into two groups(exercised; Ex and non-exercised; nE) at 6 weeks of age：SHREx(male), SHRnE(male), SHREx(female) and SHRnE(female). Exercised SHR were placed in cages with rotating wheels capable of voluntary running. After 24 weeks of feeding, values of thickness and pulse wave velocity(PWV) were measured on aortas. The results were as follows. Body weights of male SHREx were lower than those of male SHRnE, whereas female SHREx were heavier than female SHRnE. Food consumptions of SHREx groups tended to be more than those of SHRnE groups. Female SHREx showed greater running activity than male SHREx. There was no constant difference in systolic blood pressure obtained by an indirect tail-cuff method between SHREx and SHRnE in both sexes. PWV values of male SHREx were significantly lower than those of male SHRnE. In the females, there was no difference between SHREx and SHRnE. Media thickness rates(v.s. diameter) of thoracic aortas of SHREx were significantly lower than those of SHRnE in both sexes. These results suggest that voluntary exercise is effective to improve elastic characteristics of the aorta especially in male SHR.
참고문헌 (33)
- 박수현, "근력과 동맥경직도와의 관련성", 운동과학, 20(3), pp.273~282 (2011), 한국운동생리학회
- 안의수, "저항성 운동이 고혈압 전단계 및 고혈압 환자의 동맥경직도에 미치는 영향", 운동과학, 19(3), pp.301~310 (2010), 한국운동생리학회
- Allison, M. A., "Sendentary behavior and adiposity-associated inflammation：the Multi-Ethnic study of athersclerosis", Am J Prev Med, 42(1), pp.8~13 (2012)
- Amar, J., "Arterial stiffness and carvascular risk factors in a population-based study", J Hypertens, 19(3), pp.381~387 (2001)
- Asmar, R. G., "Non-invasive evaluation of arterial abnormalities in hypertensive patients", J Hypertens Suppl, 15, pp.s99~s107 (1997)
- Bentos, A., "Influence of age, risk factors, and renal disease on arterial stiffness：clinical applications", Am J Hypertens, 15(2), pp.1101~1108 (2002)
- Blacher, J., "Impact of aortic stiffness on survival in end-stage renal disease", Circulation, 99, pp.2434~2439 (1999)
- Bradley, R. L., "Voluntary exercise improves insulin sensitivity and adipose tissue inflammation in diet-induced obese mice", Am J Physiol Endocrinol Metab, 295, pp.E586~E594 (2008)
- Dekker, M. J., "Salivary cortisol is related to atherosclerosis of carotid arteries", J Clin Metab, 93(10), pp.3741~3747 (2008)
- DeVan, A. E., "Acute effects of resistance exercise on arterial compliance", J Appl Physiol, 98(6), pp.2287~2291 (2005)
- Fukao, K., "Voluntary exercise ameliorates the progression of atherosclerotic lesion formation via anti-inflammatory effects in apolipoprotein E-deficient mice", J Atheroscler Thromb, 17, pp.1226~1236 (2010)
- Graham, D. A., "Exercise training imporves aortic endothelium-dependent vasorelaxation and determinants of nitric oxide bioavailability in spontaneously hypertensive rats", J Appl Physiol, 96(6), pp.2088~2096 (2004)
- Hamer, M., "Cortisol responses to mental stress and the progression of coronary artery calcification in healthy men and women", PLos One, 7(2), pp.e31356~ (2012)
- Hägg, U., "Voluntary physical exercise-induced vascular effects in spontaneously hypertensive rats", Clinical Science, 107, pp.571~581 (2004)
- Hefferman, K. S., "Arterial stiffness and baroreflex sensitivity following bouts of aerobic and resistance exercise", Int J Sports Med, 28(3), pp.197~203 (2007)
- Heylen, E., "Effect of training freqeuncy on endothelium-dependent vasorelaxation in rats", Eur J Cardiovasc Prev Rehabil., 15(1), pp.52~58 (2008)
- Higuchi, M., "Effect of exercise training on aortic collagen content in spontaneously hypertensive rats(SHR)", Eur J Appl Physiol, 53, pp.330~338 (1995)
- Ishikawa-Takata, K., "How much exercise is required to ruduce blood pressure in essential hypertensive：a dose-response study", Am J Hypertens, 16(8), pp.629~633 (2003)
- Ke, Z., "The effects of voluntary, involuntary and forced exercise on brain-derived neurotrophic factor and motor function recovery：A rat brain ischemia model", PLoS ONE, pp.e16643~ (2011)
- Koivistonien, T., "Arterial pulse wave velocity in relation to carotid intima-media thickness, brachial flow-mediated dilation and carotid artery distensibility：the cardiovascular risk in young Finnis study and the health 2000 survey", Atherosclerosis, 220(2), pp.398~393 (2012)
- Leasure, J. L., "Forced and voluntary exercise differentially affect brain and behavior", Neuroscience, 156, pp.456~465 (2008)
- Lehmann, N., "Effects of lifestyle modification on coronary artery calcium progression and prognostic factors in coronary patients-3-year results of the randomized SAFE-LIFE trial", Atherosclerosis, 219(2), pp.630~636 (2011)
- Meissner, M., "Voluntary wheel running increases bile acid as well as cholesterol excretion and decreases atherosclerosis in hypercholesterolemic mice", Atherosclerosis, 218(2), pp.323~329 (2011)
- Motykova, E., "Lifestyle modification induced weight loss and changes of cardiometabolic risk factors including lowering of inflammatory response in obese children", Neuro Endocrinol Lett., 32(supple2), pp.55~59 (2011)
- Olujimi, A. A., "Voluntary running suppresses proinflammatory cytokines and bone marrow endothelial progenitor cell levels in apolipoprotein -E-deficient mice", Antioxid Redox Signal, 11(1), pp.15~23 (2009)
- Pinto, A., "Effects of physical exercise on inflammatory markers of atherosclerosis", Curr Pharm Des, 29 (2012)
- Roger, V. L., "Heart disease and stroke statistics-2012 update：A report from the American Association", Circulation, 125, pp.e2~e20 (2012)
- Smith, C. E., "Physical inactivity interacts with an endothelial lipase polymorphism to modulate high density lipoprotein cholesterol in the GOLDN study", Atherosclerosis, 206(2), pp.500~504 (2009)
- Sun, M. W., "Low-intensity voluntary running lowers blood pressure with simultaneous improvement in endothelium-dependent vosodilatation and insulin sensitivity in aged spontaneously hypertensive rats", Hypertens Res., 31(3), pp.543~552 (2008)
- Tipton, C. M., "Influence of exercise intensity, age, and medication on resting systolic blood pressure of SHR populations", J Appl Physiol., 55(4), pp.1305~1310 (1983)
- Toth, P. P., "Subclinical atherosclerosis：what it is, what it means and what can do about it", Int J Clin Pract, 62(8), pp.1246~1254 (2008)
- Yang, A. L., "Enhancement of vasorelaxation in hypertensive following high-intensity exercise", Chin J Physiol, 54(2), pp.87~95 (2011)
- 윤은선, "Effects of Acute Resistance Exercise on Arterial Stiffness in Young Men", Korean Circulation Journal, 40(1), pp.16~22 (2010), 대한심장학회