사전피로가 원심성 수축으로유발된 근 기능 장애에 미치는 이상성 효과
Biphasic effect of prior fatigue following eccentric-induced muscle dysfunction.
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사전 피로가 신장성 수축으로 유발된 근기능 장애의 예방 효과가 근피로에 의한 것인지 혹은 다른 요인에 의한 것인지 검증하기 위하여, 피로유발 처치 후 6분의 지연 시간을 부여하여 사전 피로의 효과를 제거한 뒤, 원심성 근수축으로 근손상을 유발하고 근파워등을 측정하였다. 실험용 쥐에서 분리한 가자미근을 시험관 내(in vitro, 35 °C)에서 사전, 사후, 회복기 30분 동안의 변화를 관찰하였다. 순환성 근파워는 5 Hz의 주기로, 근길이의 ±5 % 수축으로 측정하였다. 근피로 프로토콜은 25회의 구심성(concentric) 근수축을 처치하였고, 근손상은 10회 원심성 근수축(2Hz, 근길이±25 %)으로 처치하였다. 자료는 처치에 따른 집단 간 평균을 이원반복변량분석법(p<.05)으로 분석하였다. 원심성 근수축으로 손상된 근육(n=10)에서 근파워의 유의한 감소(37±1 %)와 30분 후 부분적인 회복(81±0 %)이 나타났다. 근피로 직후 10회의 원심성 수축을 가한 근육(n=7)은 다른 처치들에 비해 가장 큰 근파워의 감소(69±2 %)가 나타났지만, 30분 후 완전한 근파워 회복(95±5 %)이 이루어졌다. 사전 근피로가 처치되고 6분의 지연시간 후 10회의 신장성 수축을 처치한 근육(n=7)에서는 즉각적인 근파워의 감소(40±4 %)가 나타났고, 회복(79±7 %)도 부분적으로 이루어졌다. 즉, 사전피로 처치 후 6분 후의 원심성 처치는 근손상 처치만 이루어진 결과와 유사한 부정적 근손상과 근기능 장애를 유발하였다.
Abstract
Purpose：Because muscle power output was completely recovered after 6 min with in vitro intact muscle experiment, we examined the interactive effects of prior fatigue and 6 min delayed eccentric contractions. Method：Solei were subjected to work loops in vitro at 35 °C. Pre-treatment, immediate post-treatment, and post-recovery cyclical power was assessed using 3 consecutive work loops that optimized pre-treatment power output (5Hz cycles；±5 % fiber length strain). The fatigue protocol consisted of 25 consecutive optimal cycles. Damage was induced by stimulating muscles during the lengthening phase of 10 consecutive low frequency (2 Hz), high amplitude (±25 % strain) cycles. Results：Muscles subjected to damaging contractions only (N=10) showed a significant reduction in power (37±1 %) and only partially recovered after 30min (81±0 %). Muscles that were fatigued and then immediately subjected to lengthening cycles (N=7) showed reduction in power that was significantly greater than all other treatments (69±2 %), but these muscles showed complete recovery of power (95±5 %). Muscles subjected to fatigued and then treated 6 min delayed lengthening cycles (N=7) showed a significant reduction in immediate power (40±4 %) that only partially recovered (79±7 %). Thus, 6min delayed eccentric treatment showed the identical result with eccentric only treatment. Conclusion：The effect of prior fatigue on muscle power output is depending upon the time between fatigue and eccentric contractions at whole intact muscle level. It suggest that the protective effect of prior fatigue appear to be due to an adaptation of above muscle level after eccentric muscle damage, such as central nerve system.
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