본문 바로가기
KERD
논문KCI 등재

단기간의 지구성 운동 또는 리튬 처치가 고지방식 유도 비만쥐의 대사증후군에 미치는 영향.

Effects of Lithium Chloride and/or Endurance Exercise Treatment on The Metabolic Syndrome of High Fat Induced Obese Rats During 4 Weeks

0

조회

0

다운로드

2

인용

0

참고문헌

키워드

초록

PURPOSE: Investigate the effects of lithium chloride and/or endurance exercise on metabolic syndrome in high fat-induced obese rats. METHODS: 10-week-old male Sprague Dawley rats (n=45) were subjected to a high-fat diet for 8 weeks followed by lithium (2 mg/kg Lithium chloride) and/or endurance exercise (40% VO2max, 12 m/min, slop 0%, 3 d/week) for 4 weeks. RESULTS: Lithium and endurance exercise improved blood glucose and insulin response in the oral glucose tolerance test compared to the FC group, but there was no additional effect according to the combined treatment. Serum levels of AST and ALT and urinary components were similar to those of CC group. CONCLUSIONS: The short-term lithium or exercise treatment significantly improved metabolic syndrome in high fat diet induced obese rats and did not show any blood or urinary toxicity, but there was no additive effect on metabolic syndrome of combined treatments.

Abstract

PURPOSE: Investigate the effects of lithium chloride and/or endurance exercise on metabolic syndrome in high fat-induced obese rats. METHODS: 10-week-old male Sprague Dawley rats (n=45) were subjected to a high-fat diet for 8 weeks followed by lithium (2 mg/kg Lithium chloride) and/or endurance exercise (40% VO2max, 12 m/min, slop 0%, 3 d/week) for 4 weeks. RESULTS: Lithium and endurance exercise improved blood glucose and insulin response in the oral glucose tolerance test compared to the FC group, but there was no additional effect according to the combined treatment. Serum levels of AST and ALT and urinary components were similar to those of CC group. CONCLUSIONS: The short-term lithium or exercise treatment significantly improved metabolic syndrome in high fat diet induced obese rats and did not show any blood or urinary toxicity, but there was no additive effect on metabolic syndrome of combined treatments.

참고문헌 (55)

  1. Codella R, "Why should people with type 1 diabetes exercise regularly?", Acta Diabetol, 54(7), pp.615~630 (2017)
  2. 임은미, "저항성 운동이 OLETF 쥐 시상하부 Leptin receptor (Ob-R), GLUT2 mRNA 및 골격근 GLUT4 mRNA 발현에 미치는 영향", 운동과학, 27(4), pp.303~309 (2018), 한국운동생리학회[DOI]
  3. Korean Diabetes Association, "Diabetes Fact Sheet in Korea", ~ (2018)
  4. Goodyear LJ, "Exercise, glucose transport, and insulin sensitivity", Annu Rev Med, 49, pp.235~261 (1998)
  5. Hayashi T, "Exercise regulation of glucose transport in skeletal muscle", Am J Physiol, 273, pp.E1039~E1051 (1997)
  6. Goodyear LJ, "Effects of contractile activity on tyrosine phosphoproteins and phosphatidylinositol 3-kinase activity in rat skeletal muscle", Am J Physiol, 268, pp.E987~E995 (1995)
  7. Treadway JL, "Effect of exercise on insulin receptor binding and kinase activity in skeletal muscle", Am J Physiol, 256, pp.E138~E144 (1989)
  8. King PA, "Exercise, unlike insulin, promotes glucose transporter translocation in obese Zucker rat muscle", Am J Physiol, 265(2 Pt 2), pp.R447~R452 (1993)
  9. Etgen GJ Jr, "Glucose transport and cell surface GLUT-4 protein in skeletal muscle of the obese Zucker rat", Am J Physiol, 271(2 Pt 1), pp.E294~E301 (1996)
  10. Giusti CF, "Endocrine disturbances related to the use of lithium", Arq Bras Endocrinol Metabol, 56(3), pp.153~158 (2012)
  11. Collins N, "Standards of lithium monitoring in mental health Ttrusts in the UK", BMC psychiatry, 10, pp.80~ (2010)
  12. Simhandl C, "Lithium and bipolar disorder-a renaissance?", Neuropsychiatr, 21(2), pp.121~130 (2007)
  13. Bhattacharya G, "Influence of Li+ on glucose metabolism in part and rabbits", Biochimica et Biophysica Acta, 93, pp.644~646 (1964)
  14. Bosch F, "Effects of lithium ions on glycogen synthase and phosphorylase in rat hepatocytes", J Biol Chem, 261(36), pp.16927~16931 (1986)
  15. Haugaard ES, "Actions of lithium ions and insulin on glucose utilization, glycogen synthesis and glycogen synthase in the isolated rat diaphragm", Biochem Pharmacol, 23(12), pp.1675~1685 (1974)
  16. Nyfeler F, "Short-term stimulation of net glycogen production by insulin in rat hepatocytes", Biochim Biophys Acta, 675(1), pp.17~23 (1981)
  17. Kusalic M, "Effect of lithium maintenance therapy on thyroid and parathyroid function", J Psychiatry Neurosci, 24(3), pp.227~233 (1999)
  18. Harrell NB, "Essential role of p38 MAPK for activation of skeletal muscle glucose transport by lithium", Arch Physiol Biochem, 113(4-5), pp.221~227 (2007)
  19. Antonescu CN, "Reduction of insulin-stimulated glucose uptake in L6 myotubes by the protein kinase inhibitor SB203580 is independent of p38MAPK activity", Endocrinology, 146(9), pp.3773~3781 (2005)
  20. Hayashi T, "Skeletal muscle contractile activity in vitro stimulates mitogen-activated protein kinase signaling", Am J Physiol, 277(4 Pt 1), pp.C701~C707 (1999)
  21. Ren JM, "Evidence from transgenic mice that glucose transport is rate-limiting for glycogen deposition and glycolysis in skeletal muscle", J Biol Chem, 268(22), pp.16113~16115 (1993)
  22. Ribé D, "Endofacial competitive inhibition of glucose transporter-4 intrinsic activity by the mitogen-activated protein kinase inhibitor SB203580", Endocrinology, 146(4), pp.1713~1717 (2005)
  23. Somwar R, "A dominant-negative p38 MAPK mutant and novel selective inhibitors of p38MAPK reduce insulin-stimulated glucose uptake in 3T3-L1 adipocytes without affecting GLUT4 translocation", J Biol Chem, 277(52), pp.50386~50395 (2002)
  24. Jung S, "Effect of Lithium on the Mechanism of Glucose Transport in Skeletal Muscles", J Nutr Sci Vitaminol, 63(6), pp.365~371 (2017)
  25. Harvey BM, "Effect of daily lithium chloride administration on bone mass and strength in growing broiler chickens", Poult Sci, 94(2), pp.296~301 (2015)
  26. Clément-Lacroix P, "Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice", Proc Natl Acad Sci U S A, 102(48), pp.17406~17411 (2005)
  27. Scott JT, "The effect of low levels of lithium chloride in the diet of the laying hen", Poult Sci, 52(6), pp.2336~2337 (1973)
  28. Koltai E, "Age-associated declines in mitochondrial biogenesis and protein quality control factors are minimized by exercise training. American journal of physiology", Am J Physiol Regul Integr Comp Physiol, 303(2), pp.R127~R134 (2012)
  29. Tang XY, "Effects of exercise of different intensities on the angiogenesis, infarct healing, and function of the left ventricle in postmyocardial infarction rats", Coron Artery Dis, 22(7), pp.497~506 (2011)
  30. Henriksen EJ, "The high-fat-fed lean Zucker rat: a spontaneous isocaloric model of fat-induced insulin resistance associated with muscle GSK-3 overactivity", Am J Physiol Regul Integr Comp Physiol, 294(6), pp.R1813~R1821 (2008)
  31. Kim JY, "High-fat diet-induced muscle insulin resistance: relationship to visceral fat mass", Am J Physiol Regul Integr Comp Physiol, 279(6), pp.R2057~R2065 (2000)
  32. Zhong-Ze Han, "Reference Data of the Main Physiological Parameters in Control Sprague-Dawley Rats from Pre-clinical Toxicity Studies", Laboratory Animal Research, 26(2), pp.153~164 (2010), 한국실험동물학회
  33. King PA, "Insulin resistance in obese Zucker rat(fa", fa)skeletal muscle is associated with a failure of glucose transporter translocation, 1992, pp.90(4), 1568~1575
  34. Esteves JV, "MicroRNAs-Mediated Regulation of Skeletal Muscle GLUT4 Expression and Translocation in Insulin Resistance", J Diabetes Res, 2017, pp.7267910~ (2017)
  35. Philipsen A, "Associations between ultrasound measures of abdominal fat distribution and indices of glucose metabolism in a population at high risk of type 2diabetes: the ADDITION-PRO study", PLoS One, 10(4), pp.e0123062~ (2015)
  36. Neeland IJ, "Dysfunctional adiposity and the risk of prediabetes and type 2 diabetes in obese adults", JAMA, 308(11), pp.1150~1159 (2012)
  37. Wander PL, "Change in Visceral Adiposity Independently Predicts a Greater Risk of Developing Type 2 Diabetes Over 10 Years in Japanese Americans", Diabetes Care, 36(2), pp.289~293 (2013)
  38. 신윤아, "비만인의 체중감량을 위한 운동중재 방법에 대한 고찰", 운동과학, 25(4), pp.219~229 (2016), 한국운동생리학회[DOI]
  39. Voss C, "Effect of lithium on fat, protein and water content in rats", Acta Biol Med Ger, 37(8), pp.1243~1246 (1978)
  40. Colt EW, "Body composition in affective disorder before, during, and after lithium carbonate therapy", Arch Gen Psychiatry, 39(5), pp.577~581 (1982)
  41. Grandjean EM, "Lithium: updated human knowledge using an evidence-based approach. Part II: Clinical pharmacology and therapeutic monitoring", CNS Drugs, 23(4), pp.331~349 (2009)
  42. Atmaca M, "Weight gain and serum leptin levels in patients on lithium treatment", Neuropsychobiology, 46(2), pp.67~69 (2002)
  43. Dela F, "Glucose clearance in aged trained skeletal muscle during maximal insulin with superimposed exercise", J Appl Physiol, 87(6), pp.2059~2067 (1999)
  44. Stephens FB, "Metabolic and molecular changes associated with the increased skeletal muscle insulin action 24-48 h after exercise in young and old humans", Biochem Soc Trans, 46(1), pp.111~118 (2018)
  45. Bichet DG, "Lithium, cyclic AMP signaling, A-kinase anchoring proteins, and aquaporin-2", J Am Soc Nephrol, 17(4), pp.920~922 (2006)
  46. Robben JH, "Cell biological aspects of the vasopressin type-2 receptor and aquaporin 2 water channel in nephrogenic diabetes insipidus", Am J Physiol Renal Physiol, 291(2), pp.F257~F270 (2006)
  47. Trepiccione F, "Lithium-induced nephrogenic diabetes insipidus: new clinical and experimental findings", J Nephrol, 23(16), pp.S43~S48 (2010)
  48. McKnight RF, "Lithium toxicity profile : a systematic review and meta-analysis", Lancet, 379(9817), pp.721~728 (2012)
  49. Paul R, "Meta-analysis of the effects of lithium usage on serum creatinine levels", J Psychopharmacol, 24(10), pp.1425~1431 (2010)
  50. Khandelwal SK, "Renal function in long term lithium prophylaxis", Indian J Med Res, 77, pp.107~111 (1983)
  51. Gelenberg AJ, "Effects of lithium on the kidney", Acta Psychiatr Scand, 75(1), pp.29~34 (1987)
  52. Hullin RP, "Renal function after long-term treatment with lithium", Br Med J, 1(6176), pp.1457~1459 (1979)
  53. Aprahamian I, "Longterm, low-dose lithium treatment does not impair renal function in the elderly: a 2-year randomized, placebo-controlled trial followed by single-blind extension", J Clin Psychiatry, 75(7), pp.e672~e678 (2014)
  54. Coşkunol H, "Renal sideeffects of long-term lithium treatment", J Affect Disord, 43(1), pp.5~10 (1997)
  55. Turan T, "Effects of shortand long-term lithium treatment on kidney functioning in patients with bipolar mood disorder", Prog Neuropsychopharmacol Biol Psychiatry, 26(3), pp.561~565 (2002)

관련 논문AI추천

이 간행물의 다른 논문 (13건)