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Markers and makers of NKT17 cells

Park Jung-Hyun|Liman Nurcin
생화학분자생물학회 (Korean Society Of Biochemistry And Molecular Biology)|2023.12|Experimental and Molecular Medicine|제55권 |pp. 1090-1098|DOI 10.1038/s12276-023-01015-y

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참고문헌

주제분류생화학

초록

Invariant natural killer T (iNKT) cells are thymus-generated innate-like αβ T cells that undergo terminal differentiation in the thymus. Such a developmental pathway differs from that of conventional αβ T cells, which are generated in the thymus but complete their functional maturation in peripheral tissues. Multiple subsets of iNKT cells have been described, among which IL-17-producing iNKT cells are commonly referred to as NKT17 cells. IL-17 is considered a proinflammatory cytokine that can play both protective and pathogenic roles and has been implicated as a key regulatory factor in many disease settings. Akin to other iNKT subsets, NKT17 cells acquire their effector function during thymic development. However, the cellular mechanisms that drive NKT17 subset specification, and how iNKT cells in general acquire their effector function prior to antigen encounter, remain largely unknown. Considering that all iNKT cells express the canonical Vα14-Jα18 TCRα chain and all iNKT subsets display the same ligand specificity, i.e., glycolipid antigens in the context of the nonclassical MHC-I molecule CD1d, the conundrum is explaining how thymic NKT17 cell specification is determined. Mapping of the molecular circuitry of NKT17 cell differentiation, combined with the discovery of markers that identify NKT17 cells, has provided new insights into the developmental pathway of NKT17 cells. The current review aims to highlight recent advances in our understanding of thymic NKT17 cell development and to place these findings in the larger context of iNKT subset specification and differentiation.

Abstract

Invariant natural killer T (iNKT) cells are thymus-generated innate-like αβ T cells that undergo terminal differentiation in the thymus. Such a developmental pathway differs from that of conventional αβ T cells, which are generated in the thymus but complete their functional maturation in peripheral tissues. Multiple subsets of iNKT cells have been described, among which IL-17-producing iNKT cells are commonly referred to as NKT17 cells. IL-17 is considered a proinflammatory cytokine that can play both protective and pathogenic roles and has been implicated as a key regulatory factor in many disease settings. Akin to other iNKT subsets, NKT17 cells acquire their effector function during thymic development. However, the cellular mechanisms that drive NKT17 subset specification, and how iNKT cells in general acquire their effector function prior to antigen encounter, remain largely unknown. Considering that all iNKT cells express the canonical Vα14-Jα18 TCRα chain and all iNKT subsets display the same ligand specificity, i.e., glycolipid antigens in the context of the nonclassical MHC-I molecule CD1d, the conundrum is explaining how thymic NKT17 cell specification is determined. Mapping of the molecular circuitry of NKT17 cell differentiation, combined with the discovery of markers that identify NKT17 cells, has provided new insights into the developmental pathway of NKT17 cells. The current review aims to highlight recent advances in our understanding of thymic NKT17 cell development and to place these findings in the larger context of iNKT subset specification and differentiation.

참고문헌 (124)

  1. Starr, T. K., "Positive and negative selection of T cells", Annu. Rev. Immunol, 21, pp.139~176 (2003)
  2. Teh, H. S., "Thymic major histocompatibility complex antigens and the αβT-cell receptor determine the CD4", CD8 phenotype of T cells, 1988, pp.335, 229~233
  3. Singer, A., "Lineage fate and intense debate : myths, models and mechanisms of CD4-versus CD8-lineage choice", Nat. Rev. Immunol, 8, pp.788~801 (2008)
  4. Kaye, J., "Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor", Nature, 341, pp.746~749 (1989)
  5. Davis, M. M, "T-cell antigen receptor genes and T-cell recognition", Nature, 334, pp.395~402 (1988)
  6. Goncalves, P., "A new mechanism shapes the naive CD8(+)T cell repertoire : the selection for full diversity", Mol. Immunol, 85, pp.66~80 (2017)
  7. Vrisekoop, N., "Revisiting thymic positive selection and the mature T cell repertoire for antigen", Immunity, 41, pp.181~190 (2014)
  8. de Greef, P. C., "The naive T-cell receptor repertoire has an extremely broad distribution of clone sizes", eLife, 9, pp.e49900~ (2020)
  9. Bendelac, A., "The biology of NKT cells", Annu. Rev. Immunol, 25, pp.297~336 (2007)
  10. Crosby, C. M., "Tissue-specific functions of invariant natural killer T cells", Nat. Rev. Immunol, 18, pp.559~574 (2018)
  11. Dellabona, P., "An invariant Vα24-JαQ", Vβ11 T cell receptor is expressed in all individuals by clonally expanded CD4-8-T cells, 1994, pp.180, 1171~1176
  12. Lantz, O., "An invariant T cell receptor α chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8-T cells in mice and humans", J. Exp. Med, 180, pp.1097~1106 (1994)
  13. Kawano, T., "CD1d-restricted and TCR-mediated activation of Vα14 NKT cells by glycosylceramides", Science, 278, pp.1626~1629 (1997)
  14. Rossjohn, J., "Recognition of CD1d-restricted antigens by natural killer T cells", Nat Rev. Immunol, 12, pp.845~857 (2012)
  15. Burdin, N., "Selective ability of mouse CD1 to present glycolipids : α-galactosylceramide specifically stimulates Vα14+ NK T lymphocytes", J. Immunol, 161, pp.3271~3281 (1998)
  16. Zajonc, D. M., "Recognition of microbial glycolipids by natural killer T cells", Front. Immunol, 6, pp.400~ (2015)
  17. Mallevaey, T., "A molecular basis for NKT cell recognition of CD1d-selfantigen", Immunity, 34, pp.315~326 (2011)
  18. Kjer-Nielsen, L., "A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d", glycolipid recognition, 2006, pp.203, 661~673
  19. Benlagha, K., "In vivo identification of glycolipid antigen-specific T cells using fluorescent CD1d tetramers", J. Exp. Med, 191, pp.1895~1903 (2000)
  20. Matsuda, J. L., "Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramers", J. Exp. Med, 192, pp.741~754 (2000)
  21. Karadimitris, A., "Human CD1d-glycolipid tetramers generated by in vitro oxidative refolding chromatography", Proc. Natl Acad. Sci. USA, 98, pp.3294~3298 (2001)
  22. Krovi, S. H., "Invariant natural killer T cell subsets-more than just developmental intermediates", Front. Immunol, 9, pp.1393~ (2018)
  23. Wang, H., "How lipid-specific T cells become effectors : the differentiation of iNKT subsets", Front. Immunol, 9, pp.1450~ (2018)
  24. Bendelac, A., "Mouse CD1-specific NK1T cells : development, specificity, and function", Annu. Rev. Immunol, 15, pp.535~562 (1997)
  25. Crowe, N. Y., "Differential antitumor immunity mediated by NKT cell subsets in vivo", J. Exp. Med, 202, pp.1279~1288 (2005)
  26. Benlagha, K., "A thymic precursor to the NK T cell lineage", Science, 296, pp.553~555 (2002)
  27. Lee, Y. J., "Steady-state production of IL-4 modulates immunity in mouse strains and is determined by lineage diversity of iNKT cells", Nat. Immunol, 14, pp.1146~1154 (2013)
  28. 권동일, "Lineage Differentiation Program of Invariant Natural Killer T Cells", Immune Network, 17(6), pp.365~377 (2017), 대한면역학회[DOI]
  29. Cameron, G., "Differential surface phenotype and contextdependent reactivity of functionally diverse NKT cells", Immunol. Cell Biol, 96, pp.759~771 (2018)
  30. Kovalovsky, D., "The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions", Nat. Immunol, 9, pp.1055~1064 (2008)
  31. Savage, A. K., "The transcription factor PLZF directs the effector program of the NKT cell lineage", Immunity, 29, pp.391~403 (2008)
  32. Park, J. Y., "Quantitative difference in PLZF protein expression determines iNKT lineage fate and controls innate CD8 T cell generation", Cell Rep, 27, pp.2548~2557 (2019)
  33. Kimura, M. Y., "CD69 prevents PLZF(hi)innate precursors from prematurely exiting the thymus and aborting NKT2 cell differentiation", Nat. Commun, 9, pp.3749~ (2018)
  34. Bharadwaj, N. S., "Harnessing invariant natural killer T cells to control pathological inflammation", Front. Immunol, 13, pp.998378~ (2022)
  35. Van Kaer, L., "Therapeutic potential of invariant natural killer T cells in autoimmunity", Front. Immunol, 9, pp.519~ (2018)
  36. Godfrey, D. I., "Unconventional T cell targets for cancer immunotherapy", Immunity, 48, pp.453~473 (2018)
  37. McEwen-Smith, R. M., "The regulatory role of invariant NKT cells in tumor immunity", Cancer Immunol. Res, 3, pp.425~435 (2015)
  38. Maas-Bauer, K., "Invariant natural killer T-cell subsets have diverse graftversus-host-disease-preventing and antitumor effects", Blood, 138, pp.858~870 (2021)
  39. Tsagaratou, A., "Unveiling the regulation of NKT17 cell differentiation and function", Mol. Immunol, 105, pp.55~61 (2019)
  40. Hu, Y., "Dysregulated peripheral invariant natural killer T cells in plaque psoriasis patients", Front. Cell. Dev. Biol, 9, pp.799560~ (2021)
  41. Slauenwhite, D., "Regulation of NKT cell localization in homeostasis and infection", Front. Immunol, 6, pp.255~ (2015)
  42. Webster, K. E., "IL-17-producing NKT cells depend exclusively on IL-7 for homeostasis and survival", Mucosal Immunol, 7, pp.1058~1067 (2014)
  43. Lee, Y. J., "Tissue-specific distribution of iNKT cells impacts their cytokine response", Immunity, 43, pp.566~578 (2015)
  44. Bendelac, A., "Positive selection of mouse NK1+ T cells by CD1-expressing cortical thymocytes", J. Exp. Med, 182, pp.2091~2096 (1995)
  45. Egawa, T., "Genetic evidence supporting selection of the Vα14i NKT cell lineage from double-positive thymocyte precursors", Immunity, 22, pp.705~716 (2005)
  46. Gapin, L., "NKT cells derive from double-positive thymocytes that are positively selected by CD1d", Nat. Immunol, 2, pp.971~978 (2001)
  47. Griewank, K., "Homotypic interactions mediated by Slamf1 and Slamf6receptors control NKT cell lineage development", Immunity, 27, pp.751~762 (2007)
  48. Georgiev, H., "Distinct gene expression patterns correlate with developmental and functional traits of iNKT subsets", Nat. Commun, 7, pp.13116~ (2016)
  49. Lazarevic, V., "The gene encoding early growth response 2, a target of the transcription factor NFAT, is required for the development and maturation of natural killer T cells", Nat. Immunol, 10, pp.306~313 (2009)
  50. Seiler, M. P., "Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling", Nat. Immunol, 13, pp.264~271 (2012)
  51. Benlagha, K., "Characterization of the early stages of thymic NKT cell development", J. Exp. Med, 202, pp.485~492 (2005)
  52. Pellicci, D. G., "A natural killer T (NKT) cell developmental pathway iInvolving a thymus-dependent NK1.1(-)CD4(+) CD1d-dependent precursor stage", J. Exp. Med, 195, pp.835~844 (2002)
  53. Moran, A. E., "T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse", J. Exp. Med, 208, pp.1279~1289 (2011)
  54. Kumar, A., "Nur77 controls tolerance induction, terminal differentiation, and effector functions in semi-invariant natural killer T cells", Proc. Natl Acad. Sci. USA, 117, pp.17156~17165 (2020)
  55. Hough, M. R., "Defective development of thymocytes overexpressing the costimulatory molecule, heat-stable antigen", J. Exp. Med, 179, pp.177~184 (1994)
  56. Dose, M., "Intrathymic proliferation wave essential for Vα14+ natural killer T cell development depends on c-Myc", Proc. Natl Acad. Sci. USA, 106, pp.8641~8646 (2009)
  57. Mycko, M. P., "Selective requirement for c-Myc at an early stage of V(alpha)14i NKT cell development", J. Immunol, 182, pp.4641~4648 (2009)
  58. Lee, Y. J., "Lineage-specific effector signatures of invariant NKT cells are shared amongst γδT, innate lymphoid, and Th cells", J. Immunol, 197, pp.1460~1470 (2016)
  59. Wang, H., "CCR7 defines a precursor for murine iNKT cells in thymus and periphery", eLife, 7, pp.e34793~ (2018)
  60. Tuttle, K. D., "TCR signal strength controls thymic differentiation of iNKT cell subsets", Nat. Commun, 9, pp.2650~ (2018)
  61. Lee, M., "Single-cell RNA sequencing identifies shared differentiation paths of mouse thymic innate T cells", Nat. Commun, 11, pp.4367~ (2020)
  62. Baranek, T., "Deconstructing iNKT cell development at single-cell resolution", Trends Immunol, 43, pp.503~512 (2022)
  63. Pear, W. S., "Lineage choices in the developing thymus : choosing the T and NKT pathways", Curr. Opin. Immunol, 16, pp.167~173 (2004)
  64. Bezbradica, J. S., "Commitment toward the natural T(iNKT)cell lineage occurs at the CD4+8+ stage of thymic ontogeny", Proc Natl Acad Sci USA, 102, pp.5114~5119 (2005)
  65. Ligons, D. L., "RORγt limits the amount of the cytokine receptor γc through the prosurvival factor Bcl-x(L) in developing thymocytes", Sci. Signal, 11, pp.eaam8939~ (2018)
  66. Kurebayashi, S., "Retinoid-related orphan receptor γ(RORγ)is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis", Proc. Natl Acad. Sci. USA, 97, pp.10132~10137 (2000)
  67. Sun, Z., "Requirement for RORγ in thymocyte survival and lymphoid organ development", Science, 288, pp.2369~2373 (2000)
  68. Guo, J., "Regulation of the TCRα repertoire by the survival window of CD4(+)CD8(+)thymocytes", Nat. Immunol, 3, pp.469~476 (2002)
  69. Bortoluzzi, S., "Brief homogeneous TCR signals instruct common iNKT progenitors whose effector diversification is characterized by subsequent cytokine signaling", Immunity, 54, pp.2497~2513 (2021)
  70. Klibi, J., "A focus on natural killer T-cell subset characterization and developmental stages", Immunol. Cell Biol, 98, pp.358~368 (2020)
  71. Schnell, A., "T(H)17 cell heterogeneity and its role in tissue inflammation", Nat. Immunol, 24, pp.19~29 (2023)
  72. Doisne, J. M., "iNKT cell development is orchestrated by different branches of TGF-β signaling", J. Exp. Med, 206, pp.1365~1378 (2009)
  73. Rachitskaya, A. V., "Cutting edge : NKT cells constitutively express IL-23receptor and RORγt and rapidly produce IL-17 upon receptor ligation in an IL-6-independent fashion", J. Immunol, 180, pp.5167~5171 (2008)
  74. Michel, M. L., "Critical role of ROR-γt in a new thymic pathway leading to IL-17-producing invariant NKT cell differentiation", Proc. Natl Acad. Sci. USA, 105, pp.19845~19850 (2008)
  75. Moreira-Teixeira, L., "Proinflammatory environment dictates the IL-17-producing capacity of human invariant NKT cells", J. Immunol, 186, pp.5758~5765 (2011)
  76. Coquet, J. M., "Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4-NK1.1- NKT cell population", Proc. Natl Acad. Sci. USA, 105, pp.11287~11292 (2008)
  77. Stritesky, G. L., "IL-23 promotes maintenance but not commitment to the Th17 lineage", J. Immunol, 181, pp.5948~5955 (2008)
  78. Keefe, R., "Regulation of lineage commitment distinct from positive selection", Science, 286, pp.1149~1153 (1999)
  79. Kappes, D. J., "Expanding roles for ThPOK in thymic development", Immunol. Rev, 238, pp.182~194 (2010)
  80. He, X., "The zinc finger transcription factor Th-POK regulates CD4 versus CD8T-cell lineage commitment", Nature, 433, pp.826~833 (2005)
  81. Sun, G., "The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection", Nat. Immunol, 6, pp.373~381 (2005)
  82. Wang, L., "Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+)T cells", Nat. Immunol, 9, pp.1122~1130 (2008)
  83. Wang, L., "The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4+ NKT cells", Eur. J. Immunol, 40, pp.2385~2390 (2010)
  84. Bedel, R., "Effective functional maturation of invariant natural killer T cells is constrained by negative selection and T-cell antigen receptor affinity", Proc. Natl Acad. Sci. USA, 111, pp.E119~E128 (2014)
  85. Egawa, T., "ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage", Nat. Immunol, 9, pp.1131~1139 (2008)
  86. Engel, I., "Co-receptor choice by Vα14i NKT cells is driven by Th-POK expression rather than avoidance of CD8-mediated negative selection", J. Exp. Med, 207, pp.1015~1029 (2010)
  87. Luckey, M. A., "The transcription factor ThPOK suppresses Runx3 and imposes CD4(+)lineage fate by inducing the SOCS suppressors of cytokine signaling", Nat. Immunol, 15, pp.638~645 (2014)
  88. Enders, A., "ZBTB7B(Th-POK)regulates the development of IL-17-producing CD1d-restricted mouse NKT cells", J. Immunol, 189, pp.5240~5249 (2012)
  89. Engel, I., "The transcription factor Th-POK negatively regulates Th17 differentiation in Vα14i NKT cells", Blood, 120, pp.4524~4532 (2012)
  90. He, X., "CD4-CD8 lineage commitment is regulated by a silencer element at the ThPOK transcription-factor locus", Immunity, 28, pp.346~358 (2008)
  91. Wildt, K. F., "The transcription factor Zbtb7b promotes CD4 expression by antagonizing Runx-mediated activation of the CD4 silencer", J. Immunol, 179, pp.4405~4414 (2007)
  92. Egawa, T., "Antagonistic interplay between ThPOK and Runx in lineage choice of thymocytes", Blood Cells Mol. Dis, 43, pp.27~29 (2009)
  93. Liu, X., "Runt-related transcription factor 3 is involved in the altered phenotype and function in ThPok-deficient invariant natural killer T cells", Cell. Mol. Immunol, 11, pp.232~244 (2014)
  94. Levanon, D., "Structure and regulated expression of mammalian RUNX genes", Oncogene, 23, pp.4211~4219 (2004)
  95. Woolf, E., "Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis", Proc Natl Acad Sci USA, 100, pp.7731~7736 (2003)
  96. Ohno, S., "Runx proteins are involved in regulation of CD122, Ly49 family and IFN-γ expression during NK cell differentiation", Int. Immunol, 20, pp.71~79 (2008)
  97. Thapa, P., "The differentiation of ROR-γt expressing iNKT17 cells is orchestrated by Runx1", Sci. Rep, 7, pp.7018~ (2017)
  98. Lazarevic, V., "T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt", Nat. Immunol, 12, pp.96~104 (2011)
  99. Yu, J. S., "Differentiation of IL-17-producing invariant natural killer T cells requires expression of the transcription factor c-Maf", Front. Immunol, 8, pp.1399~ (2017)
  100. Schraml, B. U., "The AP-1 transcription factor Batf controls T(H)17 differentiation", Nature, 460, pp.405~409 (2009)
  101. Thapa, P., "NKAP regulates invariant NKT cell proliferation and differentiation into ROR-γt-expressing NKT17 cells", J. Immunol, 196, pp.4987~4998 (2016)
  102. Drees, C., "Roquin paralogs differentially regulate functional NKT cell subsets", J. Immunol, 198, pp.2747~2759 (2017)
  103. Uddin, M. N., "Transcription factor Bcl11b sustains iNKT1 and iNKT2 cell programs, restricts iNKT17 cell program, and governs iNKT cell survival", Proc. Natl Acad. Sci. USA, 113, pp.7608~7613 (2016)
  104. Michel, M. L., "Identification of an IL-17-producing NK1.1(neg) iNKT cell population involved in airway neutrophilia", J. Exp. Med, 204, pp.995~1001 (2007)
  105. Krovi, S. H., "Current insights in mouse iNKT and MAIT cell development using single cell transcriptomics data", Semin. Immunol, 60, pp.101658~ (2022)
  106. Godfrey, D. I., "NKT cells: what’s in a name?", Nat. Rev. Immunol, 4, pp.231~237 (2004)
  107. Engel, I., "Innate-like functions of natural killer T cell subsets result from highly divergent gene programs", Nat. Immunol, 17, pp.728~739 (2016)
  108. Luo, S., "CD138 expression is a molecular signature but not a developmental requirement for RORγt+ NKT17cells", JCI Insight, 6, pp.e148038~ (2021)
  109. Gordy, L. E., "IL-15 regulates homeostasis and terminal maturation of NKT cells", J. Immunol, 187, pp.6335~6345 (2011)
  110. Park, J. Y., "In vivo availability of the cytokine IL-7 constrains the survival and homeostasis of peripheral iNKT cells", Cell Rep, 38, pp.110219~ (2022)
  111. Hirota, K., "Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model", J. Exp. Med, 204, pp.2803~2812 (2007)
  112. Schutyser, E., "The CC chemokine CCL20 and its receptor CCR6", Cytokine Growth Factor Rev, 14, pp.409~426 (2003)
  113. Dai, H., "Syndecan-1 identifies and controls the frequency of IL-17-producing naive natural killer T(NKT17)cells in mice", Eur. J. Immunol, 45, pp.3045~3051 (2015)
  114. Palaiologou, M., "CD138(syndecan-1)expression in health and disease", Histol. Histopathol, 29, pp.177~189 (2014)
  115. Luo, S., "The cytokine receptor DR3 identifies and promotes the activation of thymic NKT17 cells", Cell. Mol. Life Sci, 80, pp.76~ (2023)
  116. Yu, Y., "Analysis of therapeutic potential of preclinical models based on DR3", TL1A pathway modulation(review), 2021, pp.22, 693~
  117. Nishikii, H., "DR3 signaling modulates the function of Foxp3+ regulatory T cells and the severity of acute graft-versus-host disease", Blood, 128, pp.2846~2858 (2016)
  118. Meylan, F., "The TNF-family cytokine TL1A promotes allergic immunopathology through group 2 innate lymphoid cells", Mucosal Immunol, 7, pp.958~968 (2014)
  119. Terashima, A., "A novel subset of mouse NKT cells bearing the IL-17 receptor B responds to IL-25 and contributes to airway hyperreactivity", J. Exp. Med, 205, pp.2727~2733 (2008)
  120. Watarai, H., "Development and function of invariant natural killer T cells producing T(h)2-and T(h)17-cytokines", PLoS Biol, 10, pp.e1001255~ (2012)
  121. Pappu, B. P., "TL1A-DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease", J. Exp. Med, 205, pp.1049~1062 (2008)
  122. Ranson, T., "IL-15 is an essential mediator of peripheral NK-cell homeostasis", Blood, 101, pp.4887~4893 (2003)
  123. Grace Yoonhee Kim, "Seeing is Believing: Illuminating the Source of In Vivo Interleukin-7", Immune Network, 11(1), pp.1~10 (2011), 대한면역학회
  124. Zhang, H., "iNKT subsets differ in their developmental and functional requirements on Foxo1", Proc. Natl Acad. Sci. USA, 118, pp.e2105950118~ (2021)

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