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The effect of intracellular trafficking of CD1d on the formation of TCR repertoire of NKT cells

박세호|신정훈
생화학분자생물학회 (Korean Society Of Biochemistry And Molecular Biology)|2014.05|BMB Reports|제47권 제5호|pp. 241-248

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참고문헌

키워드

LysosomeAntigen presentationCD1dEndosomeEndolysosomal compartmentGlycolipidNKT cells
주제분류화학

초록

CD1 molecules belong to non-polymorphic MHC class I-likeproteins and present lipid antigens to T cells. Five differentCD1 genes (CD1a-e) have been identified and classified intotwo groups. Group 1 include CD1a-c and present pathogeniclipid antigens to αβ T cells reminiscence of peptide antigenpresentation by MHC-I molecules. CD1d is the only memberof Group 2 and presents foreign and self lipid antigens to aspecialized subset of αβ T cells, NKT cells. NKT cells areinvolved in diverse immune responses through prompt andmassive production of cytokines. CD1d-dependent NKT cellsare categorized upon the usage of their T cell receptors. Amajor subtype of NKT cells (type I) is invariant NKT cellswhich utilize invariant Vα14-Jα18 TCR alpha chain in mouse. The remaining NKT cells (type II) utilize diverse TCR alphachains. Engineered CD1d molecules with modified intracellulartrafficking produce either type I or type II NKT celldefectssuggesting the lipid antigens for each subtypes of NKTcells are processed/generated in different intracellular compartments. Since the usage of TCR by a T cell is the result ofantigen-driven selection, the intracellular metabolic pathwaysof lipid antigen are a key in forming the functional NKT cell repertoire.

Abstract

CD1 molecules belong to non-polymorphic MHC class I-likeproteins and present lipid antigens to T cells. Five differentCD1 genes (CD1a-e) have been identified and classified intotwo groups. Group 1 include CD1a-c and present pathogeniclipid antigens to αβ T cells reminiscence of peptide antigenpresentation by MHC-I molecules. CD1d is the only memberof Group 2 and presents foreign and self lipid antigens to aspecialized subset of αβ T cells, NKT cells. NKT cells areinvolved in diverse immune responses through prompt andmassive production of cytokines. CD1d-dependent NKT cellsare categorized upon the usage of their T cell receptors. Amajor subtype of NKT cells (type I) is invariant NKT cellswhich utilize invariant Vα14-Jα18 TCR alpha chain in mouse. The remaining NKT cells (type II) utilize diverse TCR alphachains. Engineered CD1d molecules with modified intracellulartrafficking produce either type I or type II NKT celldefectssuggesting the lipid antigens for each subtypes of NKTcells are processed/generated in different intracellular compartments. Since the usage of TCR by a T cell is the result ofantigen-driven selection, the intracellular metabolic pathwaysof lipid antigen are a key in forming the functional NKT cell repertoire.

참고문헌 (71)

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