ALKBH5 facilitates CYP1B1 mRNA degradation via m6A demethylation to alleviate MSC senescence and osteoarthritis progression

참고문헌 (50)

1. He, S., "Senescence in health and disease", Cell, 169, pp.1000~1011 (2017)
2. Muñoz-Espín, D., "Cellular senescence : from physiology to pathology", Nat. Rev. Mol. Cell Biol, 15, pp.482~496 (2014)
3. Hernandez-Segura, A., "Hallmarks of cellular senescence", Trends Cell Biol, 28, pp.436~453 (2018)
4. Wang, W., "A genome-wide CRISPR-based screen identifies KAT7 as a driver of cellular senescence", Sci. Transl. Med, 13, pp.eabd2655~ (2021)
5. Ding, D. C., "Mesenchymal stem cells", Cell Transplant, 20, pp.5~14 (2011)
6. Soliman, H., "Multipotent stromal cells : one name, multiple identities", Cell Stem Cell, 28, pp.1690~1707 (2021)
7. Li, Y., "Senescence of mesenchymal stem cells(Review)", Int. J. Mol. Med, 39, pp.775~782 (2017)
8. Malaise, O., "Mesenchymal stem cell senescence alleviates their intrinsic and seno-suppressive paracrine properties contributing to osteoarthritis development", Aging, 11, pp.9128~9146 (2019)
9. Deng, P., "Loss of KDM4B exacerbates bone-fat imbalance and mesenchymal stromal cell exhaustion in skeletal aging", Cell Stem Cell, 28, pp.1057~1073 (2021)
10. Huang, H., "The biogenesis and precise control of RNA m6A methylation", Trends Genet, 36, pp.44~52 (2020)
11. Meyer, K. D., "Rethinking m6A readers, writers, and erasers", Annu. Rev. Cell Dev. Biol, 33, pp.319~342 (2017)
12. Shafik, A. M., "N6-methyladenosine dynamics in neurodevelopment and aging, and its potential role in Alzheimer’s disease", Genome Biol, 22, pp.17~ (2021)
13. Wang, J., "The biological function of m6A demethylase ALKBH5 and its role in human disease", Cancer Cell Int, 20, pp.347~ (2020)
14. Yu, F., "Post-translational modification of RNA m6A demethylase ALKBH5 regulates ROS-induced DNA damage response", Nucleic Acids Res, 49, pp.5779~5797 (2021)
15. Murray, G. I., "Regulation, function, and tissue-specific expression of cytochrome P450 CYP1B1", Annu. Rev. Pharmacol. Toxicol, 41, pp.297~316 (2001)
16. Dragin, N., "Phenotype of the Cyp1a1", 1a2, -triple-knockout mouse, pp.Mol. Pharmacol, 2008[DOI]
17. Lu, Y., "Procaspase-1 patrolled to the nucleus of proatherogenic lipid LPCactivated human aortic endothelial cells induces ROS promoter CYP1B1 and strong inflammation", Redox Biol, 47, pp.102142~ (2021)
18. Ye, G., "Oxidative stress-mediated mitochondrial dysfunction facilitates mesenchymal stem cell senescence in ankylosing spondylitis", Cell Death Dis, 11, pp.775~ (2020)
19. Dominici, M., "Minimal criteria for defining multipotent mesenchymal stromal cells. The international society for cellular therapy position statement", Cytotherapy, 8, pp.315~317 (2006)
20. Li, Z., "The N6-methyladenosine demethylase ALKBH5 negatively regulates the osteogenic differentiation of mesenchymal stem cells through PRMT6", Cell Death Dis, 12, pp.578~ (2021)
21. Glasson, S. S., "The OARSI histopathology initiative-Recommendations for histological assessments of osteoarthritis in the mouse", Osteoarthr. Cartil, 18, pp.S17~S23 (2010)
22. D’Adda Di Fagagna, F., "A DNA damage checkpoint response in telomereinitiated senescence", Nature, 426, pp.194~198 (2003)
23. Li, F., "Potential role of CYP1B1 in the development and treatment of metabolic diseases", Pharmacol. Ther, 178, pp.18~30 (2017)
24. Tang, Y., "m6A-Atlas : a comprehensive knowledgebase for unraveling the N6-methyladenosine(m6A)epitranscriptome", Nucleic Acids Res, 49, pp.D134~D143 (2021)
25. Zheng, Y., "m6AVar : a database of functional variants involved in m6A modification", Nucleic Acids Res, 46, pp.D139~D145 (2018)
26. Zhou, Y., "SRAMP : prediction of mammalian N6-methyladenosine(m6A)sites based on sequence-derived features", Nucleic Acids Res, 44, pp.e91~ (2016)
27. Huang, H., "Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation", Nat. Cell Biol, 20, pp.285~295 (2018)
28. Deng, L., "Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis", Nat. Commun, 10, pp.3329~ (2019)
29. Zhen, G., "Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis", Nat. Med, 19, pp.704~712 (2013)
30. Xiao, Y. Z., "Reducing hypothalamic stem cell senescence protects against aging-associated physiological decline", Cell Metab, 31, pp.534~548 (2020)
31. Zhang, H., "NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice", Science, 352, pp.1436~1443 (2016)
32. Bertero, A., "The SMAD2", 3 interactome reveals that TGFβ controls m6A mRNA methylation in pluripotency, 2018, pp.555, 256~259
33. Wu, Y., "Mettl3-mediated m6A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis", Nat. Commun, 9, pp.4772~ (2018)
34. Wu, Z., "METTL3 counteracts premature aging via m6A-dependent stabilization of MIS12 mRNA", Nucleic Acids Res, 48, pp.11083~11096 (2020)
35. Zhang, Y., "METTL3 alleviates D-gal-induced renal tubular epithelial cellular senescence via promoting miR-181a maturation", Mech Ageing Dev, 210, pp.111774~ (2023)
36. Arcidiacono, O. A., "The distinct function and localization of METTL3", METTL14 and METTL16 enzymes in cardiomyocytes, 2020, pp.21, 8139~
37. Yang, Y., "Dynamic transcriptomic m6A decoration : writers, erasers, readers and functions in RNA metabolism", Cell Res, 28, pp.616~624 (2018)
38. Ramanan, V. K., "Variants in PPP2R2B and IGF2BP3 are associated with higher tau deposition", Brain Commun, 2, pp.fcaa159~ (2020)
39. Sarparast, M., "Cytochrome P450 metabolism of polyunsaturated fatty acids and neurodegeneration", Nutrients, 12, pp.3523~ (2020)
40. Yang, Y., "Endothelium-specific CYP2J2 overexpression attenuates agerelated insulin resistance", Aging Cell, 17, pp.e12718~ (2018)
41. Bansal, S., "Mitochondrial targeting of cytochrome P450(CYP)1B1 and its role in polycyclic aromatic hydrocarbon-induced mitochondrial dysfunction", J. Biol. Chem, 289, pp.9936~9951 (2014)
42. Letts, J. A., "Clarifying the supercomplex : the higher-order organization of the mitochondrial electron transport chain", Nat. Struct. Mol. Biol, 24, pp.800~808 (2017)
43. Zhang, L., "Structural insight into the electron transfer pathway of a selfsufficient P450 monooxygenase", Nat. Commun, 11, pp.2676~ (2020)
44. Yoshigae, Y., "Role of the highly conserved threonine in cytochrome P450 2E1: prevention of H2O2-induced inactivation during electron transfer", Biochemistry, 52, pp.4636~4647 (2013)
45. Sanchez-Lopez, E., "Synovial inflammation in osteoarthritis progression", Nat. Rev. Rheumatol, 18, pp.258~275 (2022)
46. 변해옥, "From cell senescence to age-related diseases: differential mechanisms of action of senescence-associated secretory phenotypes", BMB Reports, 48(10), pp.549~558 (2015), 생화학분자생물학회
47. Yin, Y., "Roles of extracellular vesicles in the aging microenvironment and age-related diseases", J. Extracell. Vesicles, 10, pp.e12154~ (2021)
48. Lee, W. S., "Intra-articular injection of autologous adipose tissue-derived mesenchymal stem cells for the treatment of knee osteoarthritis : a phase IIb, randomized, placebo-controlled clinical trial", Stem Cells Transl. Med, 8, pp.504~511 (2019)
49. Chen, C. F., "Treatment of knee osteoarthritis with intra-articular injection of allogeneic adipose-derived stem cells(ADSCs)ELIXCYTE® : a phase I", II, randomized, active-control, single-blind, multiple-center clinical trial, 2021, pp.12, 562~
50. Krampera, M., "Mesenchymal stromal cells : putative microenvironmental modulators become cell therapy", Cell Stem Cell, 28, pp.1708~1725 (2021)

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