Roles of RNA modifications in aging and age-related diseases
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RNA modifications are key epigenetic alterations that play regulatoryfunctions in RNA biology, including RNA stability andtranslation. Emerging evidence indicates that RNA modificationis crucial for various physiological and pathological processes,including aging. This review describes functions of key RNAmodifications, including N6-methyladenosine (m6A), 5-methylcytosine(m5C), N7-methylguanosine (m7G), 2’-O-methylation(Nm), N1-methyladenosine (m1A), adenosine-to-inosine (A-to-I)RNA editing, pseudouridylation (ψ), and N4-acetylcytidine (ac4C),highlighting their roles in aging and age-associated diseases. We also discuss dynamics of RNA modifications and associatedprotein factors during aging. This review provides importantinformation on molecular mechanisms underlying aging regulation,focusing on effects of RNA modifications, which canhelp us understand healthy longevity in humans.
Abstract
RNA modifications are key epigenetic alterations that play regulatoryfunctions in RNA biology, including RNA stability andtranslation. Emerging evidence indicates that RNA modificationis crucial for various physiological and pathological processes,including aging. This review describes functions of key RNAmodifications, including N6-methyladenosine (m6A), 5-methylcytosine(m5C), N7-methylguanosine (m7G), 2’-O-methylation(Nm), N1-methyladenosine (m1A), adenosine-to-inosine (A-to-I)RNA editing, pseudouridylation (ψ), and N4-acetylcytidine (ac4C),highlighting their roles in aging and age-associated diseases. We also discuss dynamics of RNA modifications and associatedprotein factors during aging. This review provides importantinformation on molecular mechanisms underlying aging regulation,focusing on effects of RNA modifications, which canhelp us understand healthy longevity in humans.