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Double-edged sword: γδ T cells in mucosal homeostasis and disease

Kang In|Kim Yumin|Lee Heung Kyu
생화학분자생물학회 (Korean Society Of Biochemistry And Molecular Biology)|2023.12|Experimental and Molecular Medicine|제55권 |pp. 1895-1904|DOI 10.1038/s12276-023-00985-3

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초록

The mucosa is a tissue that covers numerous body surfaces, including the respiratory tract, digestive tract, eye, and urogenital tract. Mucosa is in direct contact with pathogens, and γδ T cells perform various roles in the tissue. γδ T cells efficiently defend the mucosa from various pathogens, such as viruses, bacteria, and fungi. In addition, γδ T cells are necessary for the maintenance of homeostasis because they select specific organisms in the microbiota and perform immunoregulatory functions. Furthermore, γδ T cells directly facilitate pregnancy by producing growth factors. However, γδ T cells can also play detrimental roles in mucosal health by amplifying inflammation, thereby worsening allergic responses. Moreover, these cells can act as major players in autoimmune diseases. Despite their robust roles in the mucosa, the application of γδ T cells in clinical practice is lacking because of factors such as gaps between mice and human cells, insufficient knowledge of the target of γδ T cells, and the small population of γδ T cells. However, γδ T cells may be attractive targets for clinical use due to their effector functions and low risk of inducing graft-versus-host disease. Therefore, robust research on γδ T cells is required to understand the crucial features of these cells and apply these knowledges to clinical practices.

Abstract

The mucosa is a tissue that covers numerous body surfaces, including the respiratory tract, digestive tract, eye, and urogenital tract. Mucosa is in direct contact with pathogens, and γδ T cells perform various roles in the tissue. γδ T cells efficiently defend the mucosa from various pathogens, such as viruses, bacteria, and fungi. In addition, γδ T cells are necessary for the maintenance of homeostasis because they select specific organisms in the microbiota and perform immunoregulatory functions. Furthermore, γδ T cells directly facilitate pregnancy by producing growth factors. However, γδ T cells can also play detrimental roles in mucosal health by amplifying inflammation, thereby worsening allergic responses. Moreover, these cells can act as major players in autoimmune diseases. Despite their robust roles in the mucosa, the application of γδ T cells in clinical practice is lacking because of factors such as gaps between mice and human cells, insufficient knowledge of the target of γδ T cells, and the small population of γδ T cells. However, γδ T cells may be attractive targets for clinical use due to their effector functions and low risk of inducing graft-versus-host disease. Therefore, robust research on γδ T cells is required to understand the crucial features of these cells and apply these knowledges to clinical practices.

참고문헌 (103)

  1. Menon, G. K., "The structure and function of the stratum corneum", Int. J. Pharm, 435, pp.3~9 (2012)
  2. ErikP.Lillehoj, "Airway Mucus: Its Components and Function", Archives of Pharmacal Research, 25(6), pp.770~780 (2002), 대한약학회
  3. Antoni, L., "Human colonic mucus is a reservoir for antimicrobial peptides", J. Crohns Colitis, 7, pp.e652~e664 (2013)
  4. Li, S., "Estrogen Action in the Epithelial Cells of the Mouse Vagina Regulates Neutrophil Infiltration and Vaginal Tissue Integrity", Sci. Rep, 8, pp.11247~ (2018)
  5. Houston, S. A., "The lymph nodes draining the small intestine and colon are anatomically separate and immunologically distinct", Mucosal. Immunol, 9, pp.468~478 (2016)
  6. Edelblum, K. L., "Dynamic migration of gammadelta intraepithelial lymphocytes requires occludin", Proc. Natl Acad. Sci. USA, 109, pp.7097~7102 (2012)
  7. McMenamin, C., "Regulation of IgE responses to inhaled antigen in mice by antigen-specific gamma delta T cells", Science, 265, pp.1869~1871 (1994)
  8. Luoma, A. M., "gammadelta T cell surveillance via CD1molecules", Trends Immunol, 35, pp.613~621 (2014)
  9. Di Marco Barros, R., "Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific gammadelta T Cell Compartments", Cell, 167, pp.203~218 (2016)
  10. Sutoh, Y., "Origin and Evolution of Dendritic Epidermal T Cells", Front. Immunol, 9, pp.1059~ (2018)
  11. Marlin, R., "Sensing of cell stress by human gammadelta TCR-dependent recognition of annexin A2", Proc. Natl Acad. Sci. USA, 114, pp.3163~3168 (2017)
  12. Harly, C., "Human gammadelta T cell sensing of AMPK-dependent metabolic tumor reprogramming through TCR recognition of EphA2", Sci. Immunol, 6, pp.eaba9010~ (2021)
  13. Hayday, A. C, "gammadelta T Cell Update : Adaptate Orchestrators of Immune Surveillance", J. Immunol, 203, pp.311~320 (2019)
  14. Komano, H., "Homeostatic regulation of intestinal epithelia by intraepithelial gamma delta T cells", Proc. Natl Acad. Sci. USA, 92, pp.6147~6151 (1995)
  15. Cai, Y., "Pivotal role of dermal IL-17-producing gammadelta T cells in skin inflammation", Immunity, 35, pp.596~610 (2011)
  16. Ribot, J. C., "gammadelta T cells in tissue physiology and surveillance", Nat. Rev. Immunol, 21, pp.221~232 (2021)
  17. Nandi, D., "Phenotypic analysis and gamma delta-T cell receptor repertoire of murine T cells associated with the vaginal epithelium", J. Immunol, 147, pp.1773~1778 (1991)
  18. Guy-Grand, D., "Origin, trafficking, and intraepithelial fate of gut-tropic T cells", J. Exp. Med, 210, pp.1839~1854 (2013)
  19. McCarthy, N. E., "Proinflammatory Vdelta2+ T cells populate the human intestinal mucosa and enhance IFN-gamma production by colonic alphabeta T cells", J. Immunol, 191, pp.2752~2763 (2013)
  20. McKenzie, D. R., "IL-17-producing gammadelta T cells switch migratory patterns between resting and activated states", Nat. Commun, 8, pp.15632~ (2017)
  21. Stenstad, H., "Differential homing mechanisms regulate regionalized effector CD8alphabeta+ T cell accumulation within the small intestine", Proc. Natl Acad. Sci. USA, 104, pp.10122~10127 (2007)
  22. Uehara, S., "Characterization of CCR9expression and CCL25", thymus-expressed chemokine responsiveness during T cell development : CD3(high)CD69+ thymocytes and gammadeltaTCR+ thymocytes preferentially respond to CCL25, 2002, pp.168, 134~142
  23. Ismail, A. S., "Gammadelta intraepithelial lymphocytes are essential mediators of host-microbial homeostasis at the intestinal mucosal surface", Proc. Natl Acad. Sci. USA, 108, pp.8743~8748 (2011)
  24. Wang, Y., "Murine CXCR3(+)CXCR6(+)gammadeltaT Cells Reside in the Liver and Provide Protection Against HBV Infection", Front. Immunol, 12, pp.757379~ (2021)
  25. Sim, G. K., "Homing and in situ differentiation of resident pulmonary lymphocytes", Int. Immunol, 6, pp.1287~1295 (1994)
  26. Guo, X. J., "Lung gammadelta T Cells Mediate Protective Responses during Neonatal Influenza Infection that Are Associated with Type 2 Immunity", Immunity, 49, pp.531~544 (2018)
  27. Tu, W., "The aminobisphosphonate pamidronate controls influenza pathogenesis by expanding a gammadelta T cell population in humanized mice", J. Exp. Med, 208, pp.1511~1522 (2011)
  28. Li, H., "Human Vgamma9Vdelta2-T cells efficiently kill influenza virusinfected lung alveolar epithelial cells", Cell. Mol. Immunol, 10, pp.159~164 (2013)
  29. Qin, G., "Type 1 responses of human Vgamma9Vdelta2 T cells to influenza A viruses", J. Virol, 85, pp.10109~10116 (2011)
  30. Nishimura, H., "Intraepithelial gammadelta T cells may bridge a gap between innate immunity and acquired immunity to herpes simplex virus type2", J. Virol, 78, pp.4927~4930 (2004)
  31. Rakasz, E., "Gammadelta T cell response induced by vaginal Herpes simplex 2 infection", Immunol. Lett, 70, pp.89~93 (1999)
  32. Lanza, S. R., "Simian recombinant adenovirus delivered by the mucosal route modulates gammadelta T cells from murine genital tract", Vaccine, 28, pp.4600~4608 (2010)
  33. Tuero, I., "Mucosal and Systemic gammadelta+ T Cells Associated with Control of Simian Immunodeficiency Virus Infection", J. Immunol, 197, pp.4686~4695 (2016)
  34. Alcaide, M. L., "Bacterial Vaginosis Is Associated with Loss of Gamma Delta T Cells in the Female Reproductive Tract in Women in the Miami Women Interagency HIV Study(WIHS) : A Cross Sectional Study", PLoS ONE, 11, pp.e0153045~ (2016)
  35. Kirby, A. C., "Evidence for the involvement of lung-specific gammadelta T cell subsets in local responses to Streptococcus pneumoniae infection", Eur. J. Immunol, 37, pp.3404~3413 (2007)
  36. Okamoto Yoshida, Y., "Essential role of IL-17A in the formation of a mycobacterial infection-induced granuloma in the lung", J. Immunol, 184, pp.4414~4422 (2010)
  37. Misiak, A., "IL-17-Producing Innate and Pathogen-Specific Tissue Resident Memory gammadelta T Cells Expand in the Lungs of Bordetella pertussis-Infected Mice", J. Immunol, 198, pp.363~374 (2017)
  38. Li, F., "The microbiota maintain homeostasis of liver-resident gammadeltaT-17 cells in a lipid antigen", CD1d-dependent manner, 2017, pp.7, 13839~
  39. Liang, D., "IL-23 receptor expression on gammadelta T cells correlates with their enhancing or suppressive effects on autoreactive T cells in experimental autoimmune uveitis", J. Immunol, 191, pp.1118~1125 (2013)
  40. Yao, S., "Differentiation, distribution and gammadelta T cell-driven regulation of IL-22-producing T cells in tuberculosis", PLoS Pathog, 6, pp.e1000789~ (2010)
  41. Matsukawa, M., "Tissue gamma", delta T cells in experimental urinary tract infection relationship between other immuno-competent cells, 1994, pp.68, 1498~1511
  42. Sivick, K. E., "The innate immune response to uropathogenic Escherichia coli involves IL-17A in a murine model of urinary tract infection", J. Immunol, 184, pp.2065~2075 (2010)
  43. Yu, Q., "MyD88-dependent signaling for IL-15 production plays an important role in maintenance of CD8 alpha alpha TCR alpha beta and TCR gamma delta intestinal intraepithelial lymphocytes", J. Immunol, 176, pp.6180~6185 (2006)
  44. Mathews, D. V., "CD122 signaling in CD8+ memory T cells drives costimulation-independent rejection", J. Clin. Investig, 128, pp.4557~4572 (2018)
  45. Vuletic, A., "IL-2 And IL-15 Induced NKG2D, CD158a and CD158b Expression on T, NKT-like and NK Cell Lymphocyte Subsets from Regional Lymph Nodes of Melanoma Patients", Pathol. Oncol. Res, 26, pp.223~231 (2020)
  46. Lebrero-Fernandez, C., "The ontogeny of Butyrophilin-like(Btnl)1 and Btnl6 in murine small intestine", Sci. Rep, 6, pp.31524~ (2016)
  47. Limon, J. J., "Commensal Fungi in Health and Disease", Cell Host Microbe, 22, pp.156~165 (2017)
  48. Dejima, T., "Protective role of naturally occurring interleukin-17A-producing gammadelta T cells in the lung at the early stage of systemic candidiasis in mice", Infect. Immun, 79, pp.4503~4510 (2011)
  49. Monin, L., "Response to"caution regarding interpretations of intrauterine gammadelta T cells in protection against experimental vaginal candidiasis"", Mucosal. Immunol, 14, pp.776~777 (2021)
  50. Monin, L., "gammadelta T cells compose a developmentally regulated intrauterine population and protect against vaginal candidiasis", Mucosal. Immunol, 13, pp.969~981 (2020)
  51. Wilharm, A., "Mutual interplay between IL-17-producing gammadeltaT cells and microbiota orchestrates oral mucosal homeostasis", Proc. Natl Acad. Sci. USA, 116, pp.2652~2661 (2019)
  52. Wang, L., "The microbiota protects against Pseudomonas aeruginosa pneumonia via gammadelta T cell-neutrophil axis in mice", Microbes Infect, 22, pp.294~302 (2020)
  53. St Leger, A. J., "An Ocular Commensal Protects against Corneal Infection by Driving an Interleukin-17 Response from Mucosal gammadelta T Cells", Immunity, 47, pp.148~158 (2017)
  54. Simonian, P. L., "gammadelta T cells protect against lung fibrosis via IL-22", J. Exp. Med, 207, pp.2239~2253 (2010)
  55. 윤창호, "Distribution of Interleukin-22–secreting Immune Cells in Conjunctival Associated Lymphoid Tissue", Korean Journal of Ophthalmology, 32(2), pp.147~153 (2018), 대한안과학회[DOI]
  56. Tyler, C. J., "Antigen-Presenting Human gammadelta T Cells Promote Intestinal CD4(+)T Cell Expression of IL-22 and Mucosal Release of Calprotectin", J. Immunol, 198, pp.3417~3425 (2017)
  57. Yang, F., "Dynamic Function and Composition Changes of Immune Cells During Normal and Pathological Pregnancy at the Maternal-Fetal Interface", Front. Immunol, 10, pp.2317~ (2019)
  58. Mincheva-Nilsson, L., "Pregnancy and gamma", delta T cells : taking on the hard questions, 2003, pp.1, 120~
  59. Zhang, Y., "IL-25 promotes Th2 bias by upregulating IL-4 and IL-10expression of decidual gammadeltaT cells in early pregnancy", Exp. Ther. Med, 15, pp.1855~1862 (2018)
  60. Terzieva, A., "Early Pregnancy Human Decidua is Enriched with Activated, Fully Differentiated and Pro-Inflammatory Gamma", Delta T Cells with Diverse TCR Repertoires, 2019, pp.20, 687~
  61. Yang, S., "Early pregnancy human decidua gamma", delta T cells exhibit tissue resident and specific functional characteristics, 2022, pp.28, gaac023~
  62. Clark, D. A., "TH1", TH2, 3 imbalance due to cytokine-producing NK, gammadelta T and NK-gammadelta T cells in murine pregnancy decidua in success or failure of pregnancy, 2001, pp.45, 257~265
  63. Rincon-Orozco, B., "Activation of V gamma 9V delta 2 T cells by NKG2D", J. Immunol, 175, pp.2144~2151 (2005)
  64. Zou, B., "Analysis of the expression changes of IL-17+ gammadelta T cells and Treg cells in bone marrow mesenchymal stem cells targeted therapy for allergic rhinitis", Eur. Rev. Med. Pharmacol. Sci, 25, pp.2858~2865 (2021)
  65. Hahn, Y. S., "Different potentials of gamma delta T cell subsets in regulating airway responsiveness : V gamma 1+ cells, but not V gamma 4+ cells, promote airway hyperreactivity, Th2 cytokines, and airway inflammation", J. Immunol, 172, pp.2894~2902 (2004)
  66. Hahn, Y. S., "Vgamma1+ gammadelta T cells reduce IL-10-producing CD4+CD25+ T cells in the lung of ovalbumin-sensitized and challenged mice", Immunol. Lett, 121, pp.87~92 (2008)
  67. Yang, Q., "Infiltration pattern of gammadelta T cells and its association with local inflammatory response in the nasal mucosa of patients with allergic rhinitis", Int. Forum Allergy Rhinol, 9, pp.1318~1326 (2019)
  68. Lee, W., "A Retrospective Analysis of gammadelta T Cell Expression in Chronic Rhinosinusitis and Its Association with Recurrence of Nasal Polyps", ORL J. Otorhinolaryngol. Relat. Spec, 79, pp.251~263 (2017)
  69. Spinozzi, F., "Local expansion of allergen-specific CD30+Th2-type gamma delta T cells in bronchial asthma", Mol. Med, 1, pp.821~826 (1995)
  70. Wang, B., "Activated gammadelta T Cells Promote Dendritic Cell Maturation and Exacerbate the Development of Experimental Autoimmune Uveitis(EAU)in Mice", Immunol. Investig, 50, pp.164~183 (2021)
  71. Liang, D., "Role of CD25+ dendritic cells in the generation of Th17 autoreactive T cells in autoimmune experimental uveitis", J. Immunol, 188, pp.5785~5791 (2012)
  72. Liang, D., "Retinoic acid inhibits CD25+ dendritic cell expansion and gammadelta T-cell activation in experimental autoimmune uveitis", Investig. Ophthalmol. Vis. Sci, 54, pp.3493~3503 (2013)
  73. Brandes, M., "Professional antigen-presentation function by human gammadelta T Cells", Science, 309, pp.264~268 (2005)
  74. Naganuma, M., "Cutting edge : Critical role for A2A adenosine receptors in the T cell-mediated regulation of colitis", J. Immunol, 177, pp.2765~2769 (2006)
  75. Ohta, A., "The development and immunosuppressive functions of CD4(+)CD25(+)FoxP3(+)regulatory T cells are under influence of the adenosine-A2A adenosine receptor pathway", Front. Immunol, 3, pp.190~ (2012)
  76. Fredholm, B. B., "Purines and neutrophil leukocytes", Gen. Pharmacol, 28, pp.345~350 (1997)
  77. Murphree, L. J., "Lipopolysaccharide rapidly modifies adenosine receptor transcripts in murine and human macrophages : role of NF-kappaB in A(2A)adenosine receptor induction", Biochem. J, 391, pp.575~580 (2005)
  78. Liang, D., "Roles of the adenosine receptor and CD73 in the regulatory effect of gammadelta T cells", PLoS ONE, 9, pp.e108932~ (2014)
  79. Cui, Y., "Major role of gamma delta T cells in the generation of IL-17+uveitogenic T cells", J. Immunol, 183, pp.560~567 (2009)
  80. Do, J. S., "Cutting edge : Generation of colitogenic Th17 CD4 T cells is enhanced by IL-17+ gammadelta T cells", J. Immunol, 186, pp.4546~4550 (2011)
  81. Simpson, S. J., "Expression of pro-inflammatory cytokines by TCR alpha beta + and TCR gamma delta+ T cells in an experimental model of colitis", Eur. J. Immunol, 27, pp.17~25 (1997)
  82. Kawaguchi-Miyashita, M., "An accessory role of TCRgammadelta(+)cells in the exacerbation of inflammatory bowel disease in TCRalpha mutant mice", Eur. J. Immunol, 31, pp.980~988 (2001)
  83. Dunne, M. R., "Persistent changes in circulating and intestinal gammadelta T cell subsets, invariant natural killer T cells and mucosal-associated invariant T cells in children and adults with coeliac disease", PLoS ONE, 8, pp.e76008~ (2013)
  84. Eggesbo, L. M., "Single-cell TCR sequencing of gut intraepithelial gammadelta T cells reveals a vast and diverse repertoire in celiac disease", Mucosal. Immunol, 13, pp.313~321 (2020)
  85. Risnes, L. F., "Circulating CD103(+)gammadelta and CD8(+)T cells are clonally shared with tissue-resident intraepithelial lymphocytes in celiac disease", Mucosal. Immunol, 14, pp.842~851 (2021)
  86. Alnaggar, M., "Allogenic Vgamma9Vdelta2 T cell as new potential immunotherapy drug for solid tumor : a case study for cholangiocarcinoma", J. Immunother. Cancer, 7, pp.36~ (2019)
  87. Lin, M., "Irreversible electroporation plus allogenic Vgamma9Vdelta2 T cells enhances antitumor effect for locally advanced pancreatic cancer patients", Signal Transduct. Target. Ther, 5, pp.215~ (2020)
  88. Willcox, C. R., "Butyrophilin-like 3 Directly Binds a Human Vgamma4(+)T Cell Receptor Using a Modality Distinct from Clonally-Restricted Antigen", Immunity, 51, pp.813~825 (2019)
  89. Qu, G., "Comparing Mouse and Human Tissue-Resident gammadelta T Cells", Front. Immunol, 13, pp.891687~ (2022)
  90. Deseke, M., "Ligand recognition by the gammadelta TCR and discrimination between homeostasis and stress conditions", Cell. Mol. Immunol, 17, pp.914~924 (2020)
  91. Willcox, B. E., "gammadelta TCR ligands : the quest to solve a 500-million-year-old mystery", Nat. Immunol, 20, pp.121~128 (2019)
  92. Nussbaumer, O., "Functional Phenotypes of Human Vgamma9Vdelta2T Cells in Lymphoid Stress Surveillance", Cells, 9, pp.772~ (2020)
  93. Holderness, J., "Comparative biology of gammadelta T cell function in humans, mice, and domestic animals", Annu. Rev. Anim. Biosci, 1, pp.99~124 (2013)
  94. Zhao, Z., "Targeting Strategies for Tissue-Specific Drug Delivery", Cell, 181, pp.151~167 (2020)
  95. Nussbaumer, O., "The emerging role of gammadelta T cells in cancer immunotherapy", Immunooncol. Technol, 1, pp.3~10 (2019)
  96. Makkouk, A., "Off-the-shelf Vdelta1 gamma delta T cells engineered with glypican-3(GPC-3)-specific chimeric antigen receptor(CAR)and soluble IL-15display robust antitumor efficacy against hepatocellular carcinoma", J. Immunother. Cancer, 9, pp.e003441~ (2021)
  97. Siegel, R. L., "Cancer statistics, 2022", CA Cancer J. Clin, 72, pp.7~33 (2022)
  98. Kaiser, M., "Immune Aging and Immunotherapy in Cancer", Int. J. Mol. Sci, 22, pp.7016~ (2021)
  99. Wu, Y., "Human gamma delta T cells : a lymphoid lineage cell capable of professional phagocytosis", J. Immunol, 183, pp.5622~5629 (2009)
  100. Moser, B., "Gammadelta T cells : an alternative type of professional APC", Trends Immunol, 27, pp.112~118 (2006)
  101. Quach, D. H., "A strategy to protect off-the-shelf cell therapy products using virus-specific T-cells engineered to eliminate alloreactive T-cells", J. Transl. Med, 17, pp.240~ (2019)
  102. Mo, F., "Engineered off-the-shelf therapeutic T cells resist host immune rejection", Nat. Biotechnol, 39, pp.56~63 (2021)
  103. Zhang, Y., "A Novel Strategy for Off-the-Shelf T Cell Therapy Which Evades Allogeneic T Cell and NK Cell Rejection", Blood, 138, pp.1711~1711 (2021)

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