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미성숙 랫드 자궁비대반응시험을 이용한 DEHA의 내분비계 장애작용 평가

Immatured Type Uterotrophic Assay for Estrogenicity Evaluation of DEHA

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Abstract

This study was aimed to investigate the estrogenic activity of Di-(2-ethylhexyl) adipate (DEHA) using immatured type uterotrophic assay. SD rats were treated with DEHA (40, 200, 1000 mg/kg/day), estradiol-3-benzoate (EB) (1mg/kg/day) as positive control on the assay. In immatured-type uterotrophic assay, relative organ weights of kidney and reproductive organs such as ovary at high-dose group were significantly increased compared to those of vehicle control group. DEHA did not influence the levels of serum FSH and LH, and uterine morphological changes such as luminal epithelial height, myometrial thickness and numbers of uterine gland, and BrdU indices. In these results, there was no significant variation by DEHA treatment, suggesting that DEHA appears not to be a endocrine disrupter with estrogenic activity.

참고문헌 (27)

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