본문 바로가기
KERD
논문

Bisphenol A와 butyl benzyl phthalate 동시투여가 임신랫드와 차산자에 미치는 영향

The Reproductive Toxicity by Combined Treatment of Bisphenol A and Butyl Benzyl Phthalate During Gestation, Lactation Period in Rats

권은아|김판기|황성희|최경호
한국환경보건학회 (Korean Society of Environmental Health)|2004.06|한국환경보건학회지 (JOURNAL OF ENVIRONMENTAL HEALTH SCIENCES)|제30권 제2호|pp. 71-78

1

조회

0

다운로드

0

인용

0

참고문헌

초록

Abstract

This study was performed to evaluate developmental and estrogenic activity of bisphenol A (BPA) and butyl benzyl phthalate (BBP) to the second generation of Sprague-Dawley rats ingested during gestational or lactational periods. Rats were given BPA 20 mg/kg BBP 100 mg/kg of pregnancy or lactation periods. Maternal body weight and neonatal body weight were recorded. The rats were sacrificed on day 21 after birth. Reproductive organs of dam and neonate were utilized for receptor binding assay. The plasma concentrations of BPA and MBeP, one of the major metabolites of BBP were analyzed with HPLC. The co-administration of BPA and BBP induced slow weight gain compared with single administration in dams. Also, such mixture induced low neonatal body weights in next generation. The dams treated with BPA and BBP during lactational periods showed significant organ weight changes in liver and spleen. The dams exposed during lactational periods showed significant organ weight changes not only in liver and spleen but also in kidney, uterus and ovary. The F1 female rats exposed during lactation periods showed significant organ weight changes in liver, spleen, ovary. The F1 male rats showed significant organ weight changes in liver, kidney, epididymis, vesicular glands, prostate. However, no clear synergistic effects of BPA and BBP were noted. There was no significantly different ERa expression pattern between control and treated groups. However, ERa expression were increased in F1 male testis and female uterus. F1 male showed distinct ERa expression, especially in the group of lactational combined exposure. Synergistic ERa expression was found by combined treatment of BPA and BBP. We could not find any evidences of synergistic effects on BPA and/or BBP combined administration on dams and their fetuses, except in ERa expression of F1 male.

참고문헌 (18)

  1. "Sonnenschein. Estrogenicity of resin-based composites and sealants used in dentistry", 104, pp.298~305 (1996)
  2. "an estrogenic substance is released from polycarbonate flasks during autoclaving", endocri(logy), pp.2279~2286 (1993)
  3. "Relative binding affinity-serum modified access (RBA-SMA) assay predicts the relative in vivo bioactivity of the xenoestrogens bisphenol A and octylphenol.", 105(1), pp.70~76 (1997)
  4. "Xenoestrogens released from lacquer coatings in food cans", 103(6), pp.608~612 (1995)
  5. "Bisphenol-A-diglycidyl ether (BADGE) in edible-oil-containing canned foods. Determination by LC-LC-fluorescence detection", 87(5), pp.547~558 (1996)
  6. "An estrogenic substance is released from polycarbonate flasks during autoclaving", endocri(logy), pp.2279~2286 (1993)
  7. "Studies into the transfer and migration of phthalate esters from aluminium foil-paper laminates to butter and magarine", pp.9~
  8. "Gestational and lactational exposure of rats to xenoestrogens results in reduced testicular size and sperm production", 103, pp.1136~1143 (1995)
  9. "Assessment of the mutagenicity of phthalate esters" (1982)
  10. "A variety of environmentally persistent chemicals, including some phthalate plasticizers, are weakly estrogenic", 103, pp.582~587 (1995)
  11. "excretion and metabolism of butyl benzyl phthalate in rats", pp.445~456 (1986)
  12. "Embryolethality following maternal exposure to dibutyl phthalate during early pregnancy in rats.", 58, pp.636~643 (1997)
  13. "NIOSH manual of analytical methods Department of Health and Human Service" (1984)
  14. "Principles and methods of toxicology", pp.989~1037 (1994), Raven Press
  15. "Agonistic effect of tamoxifen is dependent on cell type ERE-promoter context and estrogen receptor subtype-functional difference between estrogen receptors alpha and beta", 236(1), pp.140~145 (1997)
  16. "Assessment of effect levels of chemicals from quantitative structure-activity relationship(QSAR) models. I. Chronic lowest-observed-adverse-effect level (LOAEL).", 79((1-3)), pp.131~143 (1995)
  17. "Estrogen receptor b- a new dimension in estrogen mechanism of action", 163, pp.379~383 (1999)
  18. "Bisphenol A interacts with the estrogen receptor a in a distinct manner from estradiol", 142, pp.203~214 (1998)

관련 논문AI추천

수유기에 투여된 Butyl Benzyl Phthalate가 랫드 차산자에 미치는 영향김판기, 양율희한국환경보건학회 · 한국환경보건학회지2003 · 제29권 제2호흰쥐 수유기에 경구투여된 Bisphenol A의 영향김판기, 유재홍한국환경생물학회 · 환경생물2003 · 제21권 제2호Bisphenol A가 흰쥐의 태반 기능과 출산에 미치는 영향김대환, 김석현, 김정원, 김정호, 김종은, 김휘동, 문덕환, 손병철, 이창희, 이채관, 이채언대한예방의학회 · 예방의학회지2005 · 제38권 제3호BPA의 투여가 생쥐의 번식특성과 혈액성분에 미치는 영향김정익, 박동헌, 박춘근, 양부근, 장현용, 정희태한국축산학회 · 한국축산학회지2004 · 제46권 제6호암컷 흰쥐의 사춘기 개시에 미치는 di(2-ethyl gexyl)phthalate(DEHP)의 효과이경엽한국발생생물학회 · 발생과 생식2006 · 제10권 제2호The Bisphenol A : A Modulator of Pregnancy in RatsNaRaeLee, PanGyiKim, SeongHeeHwang한국환경보건학회 · 한국환경보건학회지2003 · 제29권 제4호

이 간행물의 다른 논문 (16건)

티오글리콜산의 랫드 피부에 대한 투과 영향황성규, 정덕체, 오세영pp. 65-70Reaction Conditions for Laccase catalyzed Degradation of？ Bisphenol A김영진pp. 79-83연속회분식 생물막 반응기(Sequencing Batch Biofilm Reator)를 이용한 수중의 유기물,질소 및 인의 동시제거에 관한 연구박민정, 김동석pp. 84-91이산화티탄 광촉매 졸(sol)의 실내환경 코팅에 의한 실내공기질 개선김대원, 양원호, 정문호, 양진섭, 박기선pp. 92-97일부 농촌지역의 오염원 현황과 먹는물 수질에 관한 조사연구김문선, 김탁수, 신해철, 이용미, 정문호, 최경호, 김성연pp. 98-103
원문 보기