A new era of macrophage-based cell therapy
2
조회
0
다운로드
0
인용
0
참고문헌
초록
Macrophages are essential innate immune cells found throughout the body that have protective and pathogenic functions in many diseases. When activated, macrophages can mediate the phagocytosis of dangerous cells or materials and participate in effective tissue regeneration by providing growth factors and anti-inflammatory molecules. Ex vivo-generated macrophages have thus been used in clinical trials as cell-based therapies, and based on their intrinsic characteristics, they outperformed stem cells within specific target diseases. In addition to the old methods of generating naïve or M2 primed macrophages, the recently developed chimeric antigen receptor-macrophages revealed the potential of genetically engineered macrophages for cell therapy. Here, we review the current developmental status of macrophage-based cell therapy. The findings of important clinical and preclinical trials are updated, and patent status is investigated. Additionally, we discuss the limitations and future directions of macrophage-based cell therapy, which will help broaden the potential utility and clinical applications of macrophages.
Abstract
Macrophages are essential innate immune cells found throughout the body that have protective and pathogenic functions in many diseases. When activated, macrophages can mediate the phagocytosis of dangerous cells or materials and participate in effective tissue regeneration by providing growth factors and anti-inflammatory molecules. Ex vivo-generated macrophages have thus been used in clinical trials as cell-based therapies, and based on their intrinsic characteristics, they outperformed stem cells within specific target diseases. In addition to the old methods of generating naïve or M2 primed macrophages, the recently developed chimeric antigen receptor-macrophages revealed the potential of genetically engineered macrophages for cell therapy. Here, we review the current developmental status of macrophage-based cell therapy. The findings of important clinical and preclinical trials are updated, and patent status is investigated. Additionally, we discuss the limitations and future directions of macrophage-based cell therapy, which will help broaden the potential utility and clinical applications of macrophages.
참고문헌 (55)
- Madge, H. M., "On transfusion of blood", Br. Med. J, 1, pp.42~44 (1874)
- Thomas, E. D., "Intravenous infusion of bone marrow in patients receiving radiation and chemotherapy", N. Engl. J. Med, 257, pp.491~496 (1957)
- Cossu, G., "Lancet Commission : stem cells and regenerative medicine", Lancet, 391, pp.883~910 (2018)
- Bashor, C. J., "Engineering the next generation of cell-based therapeutics", Nat. Rev. Drug Discov, 21, pp.655~675 (2022)
- Lyu, L., "The global chimeric antigen receptor T(CAR-T)cell therapy patent landscape", Nat. Biotechnol, 38, pp.1387~1394 (2020)
- Green, H., "Cultured cells for the treatment of disease", Sci. Am, 265, pp.96~102 (1991)
- Pellegrini, G., "Biological parameters determining the clinical outcome of autologous cultures of limbal stem cells", Regen. Med, 8, pp.553~567 (2013)
- Rama, P., "Limbal stem-cell therapy and long-term corneal regeneration", N. Engl. J. Med, 363, pp.147~155 (2010)
- Robertson, J. A, "Embryo stem cell research : ten years of controversy", J. Law Med. Ethics, 38, pp.191~203 (2010)
- Barrandon, Y., "Three clonal types of keratinocyte with different capacities for multiplication", Proc. Natl Acad. Sci. USA, 84, pp.2302~2306 (1987)
- "First stem-cell therapy recommended for approval in EU (2014)"[URL]
- Bruni, A., "Islet cell transplantation for the treatment of type 1 diabetes : recent advances and future challenges", Diabetes Metab. Syndr. Obes, 7, pp.211~223 (2014)
- Smalley, E., "Neural stem cell trailblazer StemCells folds", Nat. Biotechnol, 34, pp.677~678 (2016)
- Dunnett, S. B., "Cell therapy in Parkinson’s disease—stop or go?", Nat. Rev. Neurosci, 2, pp.365~369 (2001)
- Mendell, J. R., "Immunosuppressive therapy in Duchenne muscular dystrophy : considerations for myoblast transfer studies", Adv. Exp. Med. Biol, 280, pp.287~295 (1990)
- Villanueva, M. T., "Macrophages get a CAR", Nat. Rev. Cancer, 20, pp.300~ (2020)
- Kirouac, D. C., "Deconvolution of clinical variance in CAR-T cell pharmacology and response", Nat. Biotechnol (2023)[DOI]
- Mosser, D. M., "Exploring the full spectrum of macrophage activation", Nat. Rev. Immunol, 8, pp.958~969 (2008)
- Murray, P. J., "Protective and pathogenic functions of macrophage subsets", Nat. Rev. Immunol, 11, pp.723~737 (2011)
- Lee, S., "Macrophage-based cell therapies : the long and winding road", J. Control Release, 240, pp.527~540 (2016)
- Danon, D., "Treatment of human ulcers by application of macrophages prepared from a blood unit", Exp. Gerontol, 32, pp.633~641 (1997)
- Chernykh, E. R., "Safety and therapeutic potential of M2 macrophages in stroke treatment", Cell Transpl, 25, pp.1461~1471 (2016)
- Henry, T. D., "Safety and efficacy of ixmyelocel-T : an expanded, autologous multi-cellular therapy, in dilated cardiomyopathy", Circ. Res, 115, pp.730~737 (2014)
- Moroni, F., "Safety profile of autologous macrophage therapy for liver cirrhosis", Nat. Med, 25, pp.1560~1565 (2019)
- Suzuki, T., "Pulmonary macrophage transplantation therapy", Nature, 514, pp.450~454 (2014)
- Suzuki, T., "Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA", J. Exp. Med, 205, pp.2703~2710 (2008)
- Suzuki, T., "Hereditary pulmonary alveolar proteinosis : pathogenesis, presentation, diagnosis, and therapy", Am. J. Respir. Crit. Care Med, 182, pp.1292~1304 (2010)
- Na, Y. R., "Prostaglandin E(2)receptor PTGER4-expressing macrophages promote intestinal epithelial barrier regeneration upon inflammation", Gut, 70, pp.2249~2260 (2021)
- Gupta, N., "Neural stem cell engraftment and myelination in the human brain", Sci. Transl. Med, 4, pp.155ra137~ (2012)
- Shibuya, Y., "Treatment of a genetic brain disease by CNS-wide microglia replacement", Sci. Transl. Med, 14, pp.eabl9945~ (2022)
- Niu, Z., "Chimeric antigen receptor-modified macrophages trigger systemic anti-tumour immunity", J. Pathol, 253, pp.247~257 (2021)
- Pouyanfard, S., "Human induced pluripotent stem cell-derived macrophages ameliorate liver fibrosis", Stem Cells, 39, pp.1701~1717 (2021)
- Wang, Y., "Engineering CpG-ASO-Pt-loaded macrophages(CAP@M)for synergistic chemo-", gene-, Adv. Healthc. Mater, pp.2022, 11[DOI]
- Shields, C. W. T., "Cellular backpacks for macrophage immunotherapy", Sci. Adv, 6, pp.eaaz6579~ (2020)
- Chu, F., "Adoptive transfer of immunomodulatory M2 macrophages suppresses experimental autoimmune encephalomyelitis in C57BL", 6 mice via blockading NF-kappaB pathway, 2021, pp.204, 199~211
- Ebrahimi, L., "Transplantation of decellularised human amniotic membranes seeded with mesenchymal stem cell-educated macrophages into animal models", J. Biomed. Mater. Res. B Appl. Biomater, 110, pp.1637~1650 (2022)
- Li, B., "Effect of different types of macrophages on hepatic fibrosis in Echinococcus granulosus mice", Biomed. Pharmacother, 117, pp.109178~ (2019)
- Vagnozzi, R. J., "An acute immune response underlies the benefit of cardiac stem cell therapy", Nature, 577, pp.405~409 (2020)
- Chamberlain, C. S., "Extracellular vesicle-educated macrophages promote early Achilles tendon healing", Stem Cells, 37, pp.652~662 (2019)
- Han, G. H., "Transplantation of tauroursodeoxycholic acid-inducing M2-phenotype macrophages promotes an anti-neuroinflammatory effect and functional recovery after spinal cord injury in rats", Cell Prolif, 54, pp.e13050~ (2021)
- Podaru, M. N., "Reparative macrophage transplantation for myocardial repair : a refinement of bone marrow mononuclear cell-based therapy", Basic Res. Cardiol, 114, pp.34~ (2019)
- Murray, P. J., "Macrophage polarization", Annu. Rev. Physiol, 79, pp.541~566 (2017)
- Koba, C., "Therapeutic effect of human iPS-cell-derived myeloid cells expressing IFN-beta against peritoneally disseminated cancer in xenograft models", PLoS ONE, 8, pp.e67567~ (2013)
- Netea, M. G., "Master and commander : epigenetic regulation of macrophages", Cell Res, 26, pp.145~146 (2016)
- Freund, E. C., "Efficient gene knockout in primary human and murine myeloid cells by non-viral delivery of CRISPR-Cas9", J. Exp. Med, 217, pp.e20191692~ (2020)
- Na, Y. R., "Protein kinase A catalytic subunit is a molecular switch that promotes the pro-tumoral function of macrophages", Cell Rep, 31, pp.107643~ (2020)
- Racanelli, A. C., "Manmade macrophage offers a new therapy for pulmonary alveolar proteinosis", Am. J. Respir. Crit. Care Med, 198, pp.297~298 (2018)
- Lee, R. H., "Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6", Cell Stem Cell, 5, pp.54~63 (2009)
- Eggenhofer, E., "Mesenchymal stem cells are short-lived and do not migrate beyond the lungs after intravenous infusion", Front. Immunol, 3, pp.297~ (2012)
- Karp, J. M., "Mesenchymal stem cell homing: the devil is in the details", Cell Stem Cell, 4, pp.206~216 (2009)
- Faradji, A., "Large scale isolation of human blood monocytes by continuous flow centrifugation leukapheresis and counterflow centrifugation elutriation for adoptive cellular immunotherapy in cancer patients", J. Immunol. Methods, 174, pp.297~309 (1994)
- Andreesen, R., "Adoptive transfer of tumor cytotoxic macrophages generated in vitro from circulating blood monocytes : a new approach to cancer immunotherapy", Cancer Res, 50, pp.7450~7456 (1990)
- Andreesen, R., "Adoptive immunotherapy of cancer using monocyte-derived macrophages : rationale, current status, and perspectives", J. Leukoc. Biol, 64, pp.419~426 (1998)
- Saez-Ibanez, A. R., "Landscape of cancer cell therapies : trends and real-world data", Nat. Rev. Drug Discov, 21, pp.631~632 (2022)
- Mao, R., "Peritoneal M2 macrophage transplantation as a potential cell therapy for enhancing renal repair in acute kidney injury", J. Cell Mol. Med, 24, pp.3314~3327 (2020)
