Franz Diffusion Cell을 이용한 문신용 염료 내 유해물질의 피부 투과특성 연구
Permeation Characteristics of Hazardous Substances in Tattoo Dye using Franz Diffusion Cells
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Objectives: The purpose of this study is to determine the exposure risk to tattoo components by analyzing skinabsorption using the in vitro method. Tattoos are commonly used for cosmetic purposes, and the skin of not onlythe operator but of the people who are undergoing the cosmetic procedure is continuously exposed to hazardouschemicals. Methods: Skin permeation risk determination was conducted by the in vitro Franz diffusion cell methodaccording to the ingredient types of tattoo dyes, such as volatile organic compounds (VOCs), non-volatileorganic compounds and heavy metals, using hairless mouse full skin and human cadaver epidermis. Results: The major components with good skin penetration for each type of tattoo dye ingredient were clarified. Among the tatto dye ingredients, 1,2-Dichlorobenzene, Zn, Al, Pb and Ti showed good skin penetration. Mostof the skin transmission rates were higher in hairless mouse full skin than in human cadaver epidermis. Conclusion: A possible exposure risk to hazardous substances in tattoo dyes was confirmed from this study. These results are expected to provide a positive contribution to the establishment of management regulations fortattoo dyes.
Abstract
Objectives: The purpose of this study is to determine the exposure risk to tattoo components by analyzing skinabsorption using the in vitro method. Tattoos are commonly used for cosmetic purposes, and the skin of not onlythe operator but of the people who are undergoing the cosmetic procedure is continuously exposed to hazardouschemicals. Methods: Skin permeation risk determination was conducted by the in vitro Franz diffusion cell methodaccording to the ingredient types of tattoo dyes, such as volatile organic compounds (VOCs), non-volatileorganic compounds and heavy metals, using hairless mouse full skin and human cadaver epidermis. Results: The major components with good skin penetration for each type of tattoo dye ingredient were clarified. Among the tatto dye ingredients, 1,2-Dichlorobenzene, Zn, Al, Pb and Ti showed good skin penetration. Mostof the skin transmission rates were higher in hairless mouse full skin than in human cadaver epidermis. Conclusion: A possible exposure risk to hazardous substances in tattoo dyes was confirmed from this study. These results are expected to provide a positive contribution to the establishment of management regulations fortattoo dyes.
참고문헌 (25)
- Simon GA, "The pig as an experimental animal model of percutaneous permeation in man: qualitative and quantitative observations–an overview", Skin Pharmacol Physiol, 13(5), pp.229~234 (2000)
- Saint-Léger D, "Stratum corneum lipids in skin xerosis", Dermatologica, 177(3), pp.151~155 (1988)
- Fisher GJ, "Mechanisms of photoaging and chronological skin aging", Arch Dermatol, 138(11), pp.1462~1470 (2002)
- Chung JH, "Aging and photoaging", J Am Acad Dermatol, 49(4), pp.690~697 (2003)
- "Scientific Committee on Cosmetic Products and Non-Food Products (SCCNFP)"[URL]
- Schmook FP, "Comparison of human skin or epidermis models with human and animal skin in in-vitro percutaneous absorption", Int J Pharm, 215(1), pp.51~56 (2001)
- Ackermann K, "The Phenion® full-thickness skin model for percutaneous absorption testing", Skin Pharmacol Physiol, 23(2), pp.105~112 (2010)
- "OECD"[URL]
- 이종선, "Basal Cell Carcinoma Arising in a Tattooed Eyebrow", Annals of Dermatology, 21(3), pp.281~284 (2009), 대한피부과학회
- Juhas E, "Tattoo-associated complications", J Pediatr Adolesc Gynecol, 26(2), pp.125~129 (2013)
- Forte G, "Market survey on toxic metals contained in tattoo inks", Sci Total Environ, 407(23), pp.5997~6002 (2009)
- Brown SK., "Volatile organic pollutants in new and established buildings in Melbourne, Australia", Indoor Air, 12(1), pp.55~63 (2002)
- Franz TJ., "On the relevance of in vitro data", J invest Dermatol, 93, pp.633~640 (1975)
- Marzulli FN, "Techniques for studying skin penetration", Toxicol Appl Pharmacol, 14(3), pp.76~83 (1969)
- Barber ED, "The percutaneous absorption of hydroquinone (HQ) through rat and human skin in vitro", Toxicol Lett, 80(1), pp.167~172 (1995)
- 정덕채, "Phthalate 3종에 대한 경피투과 특성 연구", 한국환경보건학회지, 39(4), pp.360~368 (2013), 한국환경보건학회[DOI]
- Carballa M, "Removal of cosmetic ingredients and pharmaceuticals in sewage primary treatment", Water Res, 39(19), pp.4790~4796 (2005)
- Naik A, "Transdermal drug delivery: overcoming the skin’s barrier function", PSTT, 3(9), pp.318~326 (2000)
- Mavon A, "In vitro percutaneous absorption and in vivo stratum corneum distribution of an organic and a mineral sunscreen", Skin Pharmacol Physiol, 20(1), pp.10~20 (2007)
- Jjemba PK, "Excretion and ecotoxicity of pharmaceutical and personal care products in the environment", Ecotoxicol Environ Saf, 63(1), pp.113~130 (2006)
- "Handbook of Aqueous Solubility Data"[URL]
- "Chemicals Information System"[URL]
- Nemes Z, "Bricks and mortar of the epidermal barrier", KS BMB, 31(1), pp.5~19 (1999)
- Hong DH, "The Effect of Ethanol and DMSO Concentrations on Transdermal Delivery for Zaltoprofen", pp.2012
- Pappinen S, "Rat epidermal keratinocyte organotypic culture (ROC) compared to human cadaver skin: The effect of skin permeation enhancers", Eur J Pharm Sci, 30(3), pp.240~250 (2007)