비료제조공장 인근 지역의 담배특이니트로사민 환경 노출
Environmental Exposure to Tobacco-specific Nitrosamines in an Area Near a Fertilizer Plant
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초록
Objectives: This study aimed to evaluate environmental exposure to tobacco-specific nitrosamines (TSNAs) by conducting an analysis of the concentration of TSNAs in deposited dust collected from a fertilizer plant and the surrounding village, a simulation of high-temperature drying of tobacco waste, and CALPUFF modeling. Methods: The raw materials of the products, deposited dust (inside and outside the plant and residential area), soil, and wastewater were sampled and the TSNA concentrations were analyzed by LC-MS/MS. As the plant was closed down before the investigation, simulation tests were conducted to confirm the substances discharged during high-temperature (300o C) drying of tobacco waste. CALPUFF modeling was performed to identify the area of influence due to exposure to TSNAs. Results: TSNAs were detected in organic fertilizers estimated to contain tobacco waste, deposited dust, and soil collected from inside and outside the plant. N'-nitrosonornicotine (NNN), 4-(methylnitrosoamino)-1-(3-pyridyl)- 1-butanone (NNK), and N'-nitrosoanatabine (NAT) components were detected in five of 15 deposited dust samples collected from the residential area around the plant, while TSNAs were not detected in the five sampling points in the control area. Also, the simulation test for the high temperature drying of tobacco waste found emissions of TSNAs. The CALPUFF modeling results showed that the survey area was likely to be included in the area of influence of TSNA emissions from the plant. Conclusions: It is estimated that harmful tobacco ingredients such as TSNAs were dispersed in nearby areas due to the illegal use of tobacco waste as a raw material to produce organic fertilizers at the plant. These findings assume that the residents have been exposed to TSNAs and suggest that the need for the establishment of measures to manage environmental health.
Abstract
Objectives: This study aimed to evaluate environmental exposure to tobacco-specific nitrosamines (TSNAs) by conducting an analysis of the concentration of TSNAs in deposited dust collected from a fertilizer plant and the surrounding village, a simulation of high-temperature drying of tobacco waste, and CALPUFF modeling. Methods: The raw materials of the products, deposited dust (inside and outside the plant and residential area), soil, and wastewater were sampled and the TSNA concentrations were analyzed by LC-MS/MS. As the plant was closed down before the investigation, simulation tests were conducted to confirm the substances discharged during high-temperature (300o C) drying of tobacco waste. CALPUFF modeling was performed to identify the area of influence due to exposure to TSNAs. Results: TSNAs were detected in organic fertilizers estimated to contain tobacco waste, deposited dust, and soil collected from inside and outside the plant. N'-nitrosonornicotine (NNN), 4-(methylnitrosoamino)-1-(3-pyridyl)- 1-butanone (NNK), and N'-nitrosoanatabine (NAT) components were detected in five of 15 deposited dust samples collected from the residential area around the plant, while TSNAs were not detected in the five sampling points in the control area. Also, the simulation test for the high temperature drying of tobacco waste found emissions of TSNAs. The CALPUFF modeling results showed that the survey area was likely to be included in the area of influence of TSNA emissions from the plant. Conclusions: It is estimated that harmful tobacco ingredients such as TSNAs were dispersed in nearby areas due to the illegal use of tobacco waste as a raw material to produce organic fertilizers at the plant. These findings assume that the residents have been exposed to TSNAs and suggest that the need for the establishment of measures to manage environmental health.
참고문헌 (25)
- The study on the status of environmental pollution by fertilizer plant, "Iksan city", ~ (2017)
- "Studies on environmental pollution and health effects among residents in Hamna-Myeon(Jangjeom Village)"[URL]
- Staaf M, "Formation of Tobacco-Specific Nitrosamines(TSNA)during air-curing : conditions and control", Beiträge zur Tabakforschung International, 2005, pp.21(6), 321~330
- Xue J, "Mechanisms of cancer induction by tobacco-specific NNK and NNN", Cancers, 6, pp.1138~1156 (2014)
- International Agency for Research on Cancer, "IARC Monographs on the evaluation of carcinogenic risks to humans. Smokeless tobacco and some tobaccospecific N-Nitrosamines", pp.1~641 (2007), Smokeless tobacco and some tobaccospecific N-Nitrosamines
- Díez-Izquierdo A, "Update on thirdhand smoke : A comprehensive systematic review", Environmental Research, 167, pp.341~371 (2018)
- Farren NJ, "Estimated exposure risks from carcinogenic nitrosamines in urban airborne particulate matter", Environmental science & technology, 49(16), pp.9648~9656 (2015)
- Ramirez N, "Determination of nicotine and N-nitrosamines in house dust by pressurized liquid extraction and comprehensive gas chromatography-Nitrogen chemiluminiscence detection", Journal of Chromatography A, 1219, pp.180~187 (2012)
- Matt GE, "When smokers quit : exposure to nicotine and carcinogens persists from thirdhand smoke pollution", Tobacco Control, 26(5), pp.548~556 (2016)
- Matt GE, "Towards smokefree rental cars : an evaluation of voluntary smoking restrictions in California", Tobacco Control, 22, pp.201~207 (2013)
- Thomas JL, "Thirdhand tobacco smoke : a tobacco-specific lung carcinogen on surfaces in smoker’s homes", Nicotine&Tobacco Research, 16(1), pp.26~32 (2014)
- 곽수영, "흡연과 금연 나이트클럽의 간접흡연 노출의 차이에 대한 탐색연구", 한국환경보건학회지, 40(1), pp.10~16 (2014), 한국환경보건학회[DOI]
- Bahl V, "Thirdhand cigarette smoke : factors affecting exposure and remediation", PLOS ONE, 9(10), pp.e108258~ (2014)
- Khachatoorian C, "Identification and quantification of electronic cigarette exhaled aerosol residue chemicals in field sites", Environmental Research, 170, pp.351~358 (2019)
- Ferrante G, "Third-hand smoke exposure and health hazards in children", Monaldi Archives for Chest Disease, 79(1), pp.38~43 (2013)
- Ramírez N, "Exposure to nitrosamines in thirdhand tobacco smoke increases cancer risk in non-smokers", Environment International, 71, pp.139~147 (2014)
- Bahl V, "Thirdhand smoke : chemical dynamics, cytotoxicity, and genotoxicity in outdoor and indoor environments", Toxicology In Vitro, 32, pp.220~231 (2016)
- 이기영, "3차간접흡연의과학적증거의고찰", 한국환경보건학회지, 36(2), pp.77~81 (2010), 한국환경보건학회
- Wei B, "Assessing exposure to tobacco-specific carcinogen NNK using its urinary metabolite NNAL measured in US population : 2011-2012", Journal of Exposure Science and Environmental Epidemiology, 26(3), pp.249~256 (2016)
- Jacob P III, "Thirdhand smoke : new evidence, challenges, and future directions", Chemical Research Toxicology, 30(1), pp.270~294 (2017)
- Hecht SS, "Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosamines", Chemical Research in Toxicology, 11(6), pp.559~603 (1998)
- Hang B, "Thirdhand smoke causes DNA damage in human cells", Mutagenesis, 28(4), pp.381~391 (2013)
- Sarlak S, "Metabolic reprogramming by tobacco-specific nitrosamines(TSNAs)in cancer", Seminars in Cell and Developmental Biology, 98, pp.154~166 (2020)
- Da Silva FR, "Application of the buccal micronucleus cytome assay and analysis of PON1Gln192Arg and CYP2A6*9(-48T>G)polymorphisms in tobacco farmers", Environmental and Molecular Mutagenesis, 53(7), pp.525~534 (2012)
- Dhall S, "Tobacco toxins deposited on surfaces(third hand smoke)impair wound healing", Clinical Science, 130(14), pp.1269~1284 (2016)