실험동물을 이용한 화분섭취의 면역안전성 평가
Immunotoxicological Evaluation of Pollen Intake Using Mice Model
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Abstract
Pollen has been used for prevention or treatment of certain diseases such as diabetes, arthritis, or cancer in traditional medicine. In addition, pollen is under investigation as a host cell for a gene expression. This study was undertaken to evaluate the immunologic safety of pollen intake. BALB/c mice were administered with 500, 50, 5, or 0.5 mg/kg bw of lily pollen for five times a week for four weeks through gastric intubation. Comparing the control mice administered with distilled water, no significant changes were observed in body weight gain, weight of liver, spleen, lung, and histopathological findings of liver and kidney of the mice groups administered with the pollen. Plasma level of IgG1, IgG2a, and IgE was not different among the groups. When splenic B lymphocytes were stimulated in vitro with lipopolysaccharides for 7 days, level of IgG1 and IgG2a produced in the culture supernatants was not significantly different among the groups. Furthermore, no significant alteration was observed in IL-4 and IFNg producing ability with splenic T lymphocytes stimulated in vitro with phytohemagglutinins for 48 hours between the pollen-administered and the control mice. Overall, this study suggests that the lily pollen intake is inducing no significant modulation of humoral and cell-mediated immunity in mice.
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