생약복용에따른아플라톡신 B1의인체모니터링연구
Biomonitoring of Aflatoxin B1 Exposed by Herbal Medicine Intake
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초록
Aflatoxin B , a known human carcinogen, is the member of aflatoxin subfamily that is most frequently found in con 1 taminated foods. Epidemiological studies have suggested that aflatoxins may be associated with human liver cancer and acute hepatitis. Recently it was reported that the traditional medical herbs sold in domestic markets are contaminated with aflatoxins. Long-term administration of these contaminated medicines could result in adverse health effects. Therefore, it is important to evaluate the levels of exposure to aflatoxin in people who ingest traditional herbal medicines. Blood samples were collected, before and after the herbal medicine intake, from 151 subjects who visited the hospital. The metabolite of aflatoxin B in blood, aflatoxin B-albumin (aflatoxin B-lysine), is reportedly an appropriate internal 11 1exposure indicator, and its levels in the collected bloods were therefore analyzed using a liquid chromatography-mass spectrometry. The analytical method of aflatoxin B-lysine in blood was firstly optimized in Korea and the levels were 1 detected below quantification limits (2 pg/mg albumin) in this study population. Consequently, the exposure levels of aflatoxin B by ingestion of herbal medicines were low but it is important to monitor routinely due to the possibility 1of risk on the aflatoxin exposure.
Abstract
Aflatoxin B , a known human carcinogen, is the member of aflatoxin subfamily that is most frequently found in con 1 taminated foods. Epidemiological studies have suggested that aflatoxins may be associated with human liver cancer and acute hepatitis. Recently it was reported that the traditional medical herbs sold in domestic markets are contaminated with aflatoxins. Long-term administration of these contaminated medicines could result in adverse health effects. Therefore, it is important to evaluate the levels of exposure to aflatoxin in people who ingest traditional herbal medicines. Blood samples were collected, before and after the herbal medicine intake, from 151 subjects who visited the hospital. The metabolite of aflatoxin B in blood, aflatoxin B-albumin (aflatoxin B-lysine), is reportedly an appropriate internal 11 1exposure indicator, and its levels in the collected bloods were therefore analyzed using a liquid chromatography-mass spectrometry. The analytical method of aflatoxin B-lysine in blood was firstly optimized in Korea and the levels were 1 detected below quantification limits (2 pg/mg albumin) in this study population. Consequently, the exposure levels of aflatoxin B by ingestion of herbal medicines were low but it is important to monitor routinely due to the possibility 1of risk on the aflatoxin exposure.
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