모의 실험주택 모니터링 결과를 활용한 실내공기 및 바닥먼지 중 Di(2-ethyl-hexyl) phthalate (DEHP)의 이론적 총량 비율 산출
Calculation of the Theoretical Total Amount Ratio of Di(2-ethyl-hexyl) Phthalate in Indoor Air and Floor Dust in a Test House
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Background: Human exposure to phthalates in indoor environments occurs via dermal absorption, oral ingestion of indoor dust, and inhalation of indoor air. However, systematic studies to investigate the exposure rate to phthalates among the three exposure routes in indoor environments are currently limited. Objectives: A theoretical exposure ratio between inhalation and oral exposure was calculated based on the total amount of di(2-ethyl-hexyl) phthalate (DEHP) emitted into indoor air and deposited into f loor dust in a test house. Methods: Flooring and wallpaper containing DEHP were installed in a test house and the concentration of DEHP in both indoor air and f loor dust were monitored for five months. Based on the measured DEHP concentrations, the theoretical total amount ratio of DEHP that could be exposed through inhalation and oral ingestion was calculated. Results: Considering the period of operation in the test house, the theoretical total amount of DEHP through inhalation and oral ingestion exposures in the entire test house space was calculated to be 0.014 mg and 5.5 mg, respectively. The exposure ratio of the two routes between inhalation and oral exposure corresponding to the total DEHP amount in f looring and wallpaper was 6.0×10–7% and 2.3×10–4%, indicating that theoretical oral exposure to DEHP is approximately 380 times higher than inhalation. Conclusions: Monitoring results from a test house has shown that oral exposure is the main exposure route for DEHP in indoor environments. The experimental design employed in this study and theoretical exposure ratio obtained can be applied to investigate actual exposure to DEHP and to determine the exposure characteristics of various types of semi-volatile organic compounds.
Abstract
Background: Human exposure to phthalates in indoor environments occurs via dermal absorption, oral ingestion of indoor dust, and inhalation of indoor air. However, systematic studies to investigate the exposure rate to phthalates among the three exposure routes in indoor environments are currently limited. Objectives: A theoretical exposure ratio between inhalation and oral exposure was calculated based on the total amount of di(2-ethyl-hexyl) phthalate (DEHP) emitted into indoor air and deposited into f loor dust in a test house. Methods: Flooring and wallpaper containing DEHP were installed in a test house and the concentration of DEHP in both indoor air and f loor dust were monitored for five months. Based on the measured DEHP concentrations, the theoretical total amount ratio of DEHP that could be exposed through inhalation and oral ingestion was calculated. Results: Considering the period of operation in the test house, the theoretical total amount of DEHP through inhalation and oral ingestion exposures in the entire test house space was calculated to be 0.014 mg and 5.5 mg, respectively. The exposure ratio of the two routes between inhalation and oral exposure corresponding to the total DEHP amount in f looring and wallpaper was 6.0×10–7% and 2.3×10–4%, indicating that theoretical oral exposure to DEHP is approximately 380 times higher than inhalation. Conclusions: Monitoring results from a test house has shown that oral exposure is the main exposure route for DEHP in indoor environments. The experimental design employed in this study and theoretical exposure ratio obtained can be applied to investigate actual exposure to DEHP and to determine the exposure characteristics of various types of semi-volatile organic compounds.
참고문헌 (27)
- Socio-economic assessment of phthalates, "Holland M", Organisation for Economic Co-operation and Development, ~, pp.ENV (2018), WKP(2018)7
- Wang Y, "Phthalates and their impacts on human health", Healthcare(Basel), 9(5), pp.603~ (2021)
- Eales J, "Human health impacts of exposure to phthalate plasticizers : an overview of reviews", Environ Int, 158, pp.106903~ (2022)
- 심기태, "어린이용품 중 프탈레이트류 확률론적 노출평가연구", 환경분석과 독성보건, 21(1), pp.41~51 (2018), 한국환경분석학회
- Kim DY, "Phthalate plasticizers in children's products and estimation of exposure : importance of migration rate", Int J Environ Res Public Health, 17(22), pp.8582~ (2020)
- Study on the aggregated risk assessment of phthalates to human health, "National Institute of Food and Drug Safety Evaluation (NIFDS)", NIFDS, ~, pp.TRKO202000029950 (2019)
- 양지연, "생체시료를 이용한 프탈레이트의 실내 노출인자 연구", 실내환경 및 냄새 학회지, 17(4), pp.315~321 (2018), 한국냄새환경학회[DOI]
- Khaled R, "Human biomonitoring of environmental contaminants in Gulf Countries - current status and future directions", Environ Res, 236(Pt 1), pp.116650~ (2023)
- Arbuckle TE, "Measurement of 24 phthalate metabolites in 1st trimester urine samples: the MIREC study", Chemosphere, 338, pp.139603~ (2023)
- Shinohara N, "Emission characteristics of diethylhexyl phthalate(DEHP)from building materials determined using a passive flux sampler and microchamber", PLoS One, 14(9), pp.e0222557~ (2019)
- Jeon S, "Migration of DEHP and DINP into dust from PVC flooring products at different surface temperature", Sci Total Environ, 547, pp.441~446 (2016)
- Shinohara N, "Diethylhexyl phthalate(DEHP)emission to indoor air and transfer to house dust from a PVC sheet", Sci Total Environ, 711, pp.134573~ (2020)
- Little JC, "Rapid methods to estimate potential exposure to semivolatile organic compounds in the indoor environment", Environ Sci Technol, 46(20), pp.11171~11178 (2012)
- 전정인, "실내환경 중 집먼지 및 유기필름에서 기인한 프탈레이트 노출평가", 한국환경보건학회지, 48(2), pp.75~85 (2022), 한국환경보건학회[DOI]
- Bi C, "Fate and transport of phthalates in indoor environments and the influence of temperature : a case study in a test house", Environ Sci Technol, 49(16), pp.9674~9681 (2015)
- Guo Y, "Comparative assessment of human exposure to phthalate esters from house dust in China and the United States", Environ Sci Technol, 45(8), pp.3788~3794 (2011)
- "Floorcovering-PVC. (KS Standard No. M 3802)"[URL]
- "Wallpapers and floor coverings on a base of paper (regulation of Korean Agency for Technology and Standards No. 2021-0483)"[URL]
- "Determination of phthalate plasticizers in polymer materials (KS Standard No. M 1991)"[URL]
- "Regulation of National Institute of Environmental Research No. 2023-1 (2023.01.05.)"[URL]
- "Indoor airpart 33: determination of phthalates with gas chromatography/mass spectrometry (GC/MS)"[URL]
- "Standard practice for collection of floor dust for chemical analysis"[URL]
- Dueñas-Mas MJ, "Supramolecular solvent-based microextraction of aryl-phosphate flame retardants in indoor dust from houses and education buildings in Spain", Sci Total Environ, 733, pp.139291~ (2020)
- Dubocq F, "Comprehensive chemical characterization of indoor dust by target, suspect screening and nontarget analysis using LC-HRMS and GC-HRMS", Environ Pollut, 276, pp.116701~ (2021)
- Jílková S, "Small-scale spatial variability of flame retardants in indoor dust and implications for dust sampling", Chemosphere, 206, pp.132~141 (2018)
- National Institute of Environmental Research(NIER), "Korean exposure factors handbook", NIER, ~ (2019)
- National Institute of Environmental Research(NIER), "Korean exposure factors handbook for children", NIER, ~ (2019)