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가습기살균제 피해구제 신청자들의 신청 차수별 노출 특성 변화 - 1차에서 5차 신청자를 중심으로 -

Individual Exposure Characteristics according to the Humidifier Disinfectant Exposure Assessment Cycle - Focusing on Cycles I-to-V Applicants -

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초록

Background: An ongoing environmental exposure assessment of humidifier disinfectants (HDs) has been conducted since November 2011 among individuals who experienced HD exposure-related adverse health effects. It is being performed in order to determine and quantify exposure to humidifier disinfectants in victims and their families. To date, the assessment has encompassed Cycles I-to-V. There is no report summarizing the characteristics of the subjects from the overall cycles. Objectives: We intended to examine the individual characteristics related to demographics, HD usage, and HD exposure using integrated data from Cycles I-to-V of the environmental exposure assessment of HDs and the changes with the cycles. Methods: We included 7,543 individuals who participated in Cycles I-to-V of the environmental exposure assessment of HDs. We summarized the participants’ characteristics regarding their demographics (e.g., sex, education level, and age), HD usage history (e.g., product name, ingredient, and frequency of HD use), and HD exposure (e.g., daily time of HD use, cumulative time of HD use, and exposure intensity). In addition, their characteristics were compared across the cycles of the exposure assessment. Results: Among the 7,543 participants from Cycles I-to-V, there were more male participants than females (51.05% overall), except for Cycles I and III. Across all cycles, a higher proportion of survivors was observed than deceased individuals. While PHMG was the most prevalent ingredient in HDs throughout all the cycles, its proportion gradually decreased over the course of the examination cycles. Participants in Cycle I reported longer daily times of HD use compared to those in the subsequent cycles. On the other hand, cumulative time of HD use was shorter in the earlier cycles than in the later cycles. Conclusions: Using the integrated data from the full cycles of the environmental exposure assessment, this study identified changes in demographic characteristics as well as the HD exposure characteristics between the participants across different cycles.

Abstract

Background: An ongoing environmental exposure assessment of humidifier disinfectants (HDs) has been conducted since November 2011 among individuals who experienced HD exposure-related adverse health effects. It is being performed in order to determine and quantify exposure to humidifier disinfectants in victims and their families. To date, the assessment has encompassed Cycles I-to-V. There is no report summarizing the characteristics of the subjects from the overall cycles. Objectives: We intended to examine the individual characteristics related to demographics, HD usage, and HD exposure using integrated data from Cycles I-to-V of the environmental exposure assessment of HDs and the changes with the cycles. Methods: We included 7,543 individuals who participated in Cycles I-to-V of the environmental exposure assessment of HDs. We summarized the participants’ characteristics regarding their demographics (e.g., sex, education level, and age), HD usage history (e.g., product name, ingredient, and frequency of HD use), and HD exposure (e.g., daily time of HD use, cumulative time of HD use, and exposure intensity). In addition, their characteristics were compared across the cycles of the exposure assessment. Results: Among the 7,543 participants from Cycles I-to-V, there were more male participants than females (51.05% overall), except for Cycles I and III. Across all cycles, a higher proportion of survivors was observed than deceased individuals. While PHMG was the most prevalent ingredient in HDs throughout all the cycles, its proportion gradually decreased over the course of the examination cycles. Participants in Cycle I reported longer daily times of HD use compared to those in the subsequent cycles. On the other hand, cumulative time of HD use was shorter in the earlier cycles than in the later cycles. Conclusions: Using the integrated data from the full cycles of the environmental exposure assessment, this study identified changes in demographic characteristics as well as the HD exposure characteristics between the participants across different cycles.

참고문헌 (20)

  1. Korea Centers for Disease Control and Prevention, "White paper on the health-related damage caused by humidifier disinfectants" (2014), Hanrimwon
  2. Case studies on victims of humidifier disinfectants, "Korean Society of Environmental Health(KSEH)", KSEH, ~ (2012)
  3. 김지원, "염화벤잘코늄(Benzalkonium chloride) 살균제의 용도 및 건강 위험에 대한 고찰 -가습기 살균제를 중심으로", 한국환경보건학회지, 47(6), pp.513~520 (2021), 한국환경보건학회[DOI]
  4. Seo D, "Humidifier disinfectant, sodium dichloroisocyanurate(NaDCC) : assessment of respiratory effects to protect workers'health", Sci Rep, 11(1), pp.15681~ (2021)
  5. 이종현, "Refined Exposure Assessment for Three Active Ingredients of Humidifier Disinfectants", Environmental Engineering Research, 18(4), pp.253~257 (2013), 대한환경공학회[DOI]
  6. Park S, "Humidifier disinfectant-associated interstitial lung disease in an animal model induced by polyhexamethylene guanidine aerosol", Am J Respir Crit Care Med, 190(6), pp.706~708 (2014)
  7. Yoon J, "Humidifier disinfectant consumption and humidifier disinfectant-associated lung injury in South Korea : a nationwide population-based study", Int J Environ Res Public Health, 18(11), pp.6136~ (2021)
  8. Report on total sales of humidifier disinfectant, "Asian Citizen’s Center for Environment and Health", Asian Citizen’s Center for Environment and Health, ~, pp.Report No.: 296, 2017-23 (2017)
  9. 이경무, "가습기 살균제 노출 및 건강피해 규모 평가 연구", 한국환경보건학회지, 45(3), pp.273~284 (2019), 한국환경보건학회[DOI]
  10. "Comprehensive portal for humidifier disinfectant damage support:statistics"[URL]
  11. "Enforcement decree of the special act on remedy for damage caused by humidifier disinfectants. Article 1"[URL]
  12. 이슬아, "가습기살균제 환경노출 판정등급에 따른 개인 노출 특성 분포 - 4-1차와 4-2차 신청자를 중심으로", 한국환경보건학회지, 45(4), pp.370~380 (2019), 한국환경보건학회[DOI]
  13. 최윤형, "가습기살균제 피해 신청자들의 인구학적 특성 및 노출평가 - 4-1차와 4-2차 신청자를 중심으로 -", 한국환경보건학회지, 44(4), pp.301~314 (2018), 한국환경보건학회
  14. 박동욱, "가습기 살균제 폐 손상 피해자의 살균제 노출 특성 -태아와 임산부 노출을 중심으로 -", 한국환경보건학회지, 42(3), pp.147~159 (2016), 한국환경보건학회
  15. "Environmental damage relief and support"[URL]
  16. 1st Study on the relationship between the use of humidifier disinfectant and lung injury, "Korea Centers for Disease Control and Prevention (KCDC)", KCDC, 6~9 (2014)
  17. 2nd Study on the relationship between the use of humidifier disinfectant and lung injury, "Ministry of Environment", Ministry of Environment, ~ (2015)
  18. 최예용, "가습기살균제 참사의 진행과 교훈(Q&A)", 한국환경보건학회지, 43(1), pp.1~22 (2017), 한국환경보건학회
  19. Comprehensive report on the humidifier disinfectant, "Special Investigation Commission on Humidifier Disinfectants", Special Investigation Commission on Humidifier Disinfectants and 4.16 Sewol Ferry Disasters, ~ (2022)
  20. 박동욱, "가습기 살균제 피해자 호흡기로 흡입된 가습기 살균제 양 추정 - 호흡기 외부(external) 및 내부 노출(internal exposure) 추정 방법과 사례 -", 한국환경보건학회지, 42(3), pp.141~146 (2016), 한국환경보건학회

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